The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer

The Integrated Stress Response (ISR) is a cytoprotective pathway upregulated in many cancers. Here the authors show that the activation of PERK/p-eIF2α arm of ISR enhances ERK phosphorylation through translation repression of DUSP6, thus resulting in KRAS-driven lung tumorigenesis.

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Autores principales:	Nour Ghaddar, Shuo Wang, Bethany Woodvine, Jothilatha Krishnamoorthy, Vincent van Hoef, Cedric Darini, Urszula Kazimierczak, Nicolas Ah-son, Helmuth Popper, Myriam Johnson, Leah Officer, Ana Teodósio, Massimo Broggini, Koren K. Mann, Maria Hatzoglou, Ivan Topisirovic, Ola Larsson, John Le Quesne, Antonis E. Koromilas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c5184c726c2a4e1fa460c06a009a5df9
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spelling	oai:doaj.org-article:c5184c726c2a4e1fa460c06a009a5df92021-12-02T16:24:57ZThe integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer10.1038/s41467-021-24661-02041-1723https://doaj.org/article/c5184c726c2a4e1fa460c06a009a5df92021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24661-0https://doaj.org/toc/2041-1723The Integrated Stress Response (ISR) is a cytoprotective pathway upregulated in many cancers. Here the authors show that the activation of PERK/p-eIF2α arm of ISR enhances ERK phosphorylation through translation repression of DUSP6, thus resulting in KRAS-driven lung tumorigenesis.Nour GhaddarShuo WangBethany WoodvineJothilatha KrishnamoorthyVincent van HoefCedric DariniUrszula KazimierczakNicolas Ah-sonHelmuth PopperMyriam JohnsonLeah OfficerAna TeodósioMassimo BrogginiKoren K. MannMaria HatzoglouIvan TopisirovicOla LarssonJohn Le QuesneAntonis E. KoromilasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nour Ghaddar Shuo Wang Bethany Woodvine Jothilatha Krishnamoorthy Vincent van Hoef Cedric Darini Urszula Kazimierczak Nicolas Ah-son Helmuth Popper Myriam Johnson Leah Officer Ana Teodósio Massimo Broggini Koren K. Mann Maria Hatzoglou Ivan Topisirovic Ola Larsson John Le Quesne Antonis E. Koromilas The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
description	The Integrated Stress Response (ISR) is a cytoprotective pathway upregulated in many cancers. Here the authors show that the activation of PERK/p-eIF2α arm of ISR enhances ERK phosphorylation through translation repression of DUSP6, thus resulting in KRAS-driven lung tumorigenesis.
format	article
author	Nour Ghaddar Shuo Wang Bethany Woodvine Jothilatha Krishnamoorthy Vincent van Hoef Cedric Darini Urszula Kazimierczak Nicolas Ah-son Helmuth Popper Myriam Johnson Leah Officer Ana Teodósio Massimo Broggini Koren K. Mann Maria Hatzoglou Ivan Topisirovic Ola Larsson John Le Quesne Antonis E. Koromilas
author_facet	Nour Ghaddar Shuo Wang Bethany Woodvine Jothilatha Krishnamoorthy Vincent van Hoef Cedric Darini Urszula Kazimierczak Nicolas Ah-son Helmuth Popper Myriam Johnson Leah Officer Ana Teodósio Massimo Broggini Koren K. Mann Maria Hatzoglou Ivan Topisirovic Ola Larsson John Le Quesne Antonis E. Koromilas
author_sort	Nour Ghaddar
title	The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
title_short	The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
title_full	The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
title_fullStr	The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
title_full_unstemmed	The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
title_sort	integrated stress response is tumorigenic and constitutes a therapeutic liability in kras-driven lung cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c5184c726c2a4e1fa460c06a009a5df9
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The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer

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