Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer

Abstract Serum from one hundred and ten breast cancer patients and thirty healthy female volunteers, were prospectively collected and evaluated for serum levels of Shh and IL-6 using human Shh and IL-6 specific enzyme-linked immunoassays. All patients were regularly monitored for event free survival...

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Autores principales:	A. S. Noman, M. Uddin, A. A. Chowdhury, M. J. Nayeem, Z. Raihan, M. I. Rashid, A. K. Azad, M. L. Rahman, D. Barua, A. Sultana, A. Shirin, J. Ferdous, R. R. Parag, S. M. Rahman, M. R. Mahmud, C. S. Jerin, N. Jahan, A. Siddiqua, T. Ara, E. B. Sabur, S. S. Alam, S. Baidya, S. Akther, M. Z. Rahman, T. Banu, A. K. Murugan, S. Sabri, S. M. S. Islam, B. Karakas, A. Aboussekhra, H. Yeger, W. A. Farhat, S. S. Islam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c51c6852ee1e41158865136280d53ecd
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spelling	oai:doaj.org-article:c51c6852ee1e41158865136280d53ecd2021-12-02T15:05:16ZSerum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer10.1038/s41598-017-01268-42045-2322https://doaj.org/article/c51c6852ee1e41158865136280d53ecd2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01268-4https://doaj.org/toc/2045-2322Abstract Serum from one hundred and ten breast cancer patients and thirty healthy female volunteers, were prospectively collected and evaluated for serum levels of Shh and IL-6 using human Shh and IL-6 specific enzyme-linked immunoassays. All patients were regularly monitored for event free survival (EFS) and overall survival (OS). Overall outcome analysis was based on serum Shh and IL-6 levels. In patients with progressive metastatic BC, both serum Shh and IL-6 concentrations were elevated in 44% (29 of 65) and 63% (41 of 65) of patients, respectively, at a statistically significant level [Shh (p = 0.0001) and IL-6 (p = 0.0001)] compared to the low levels in healthy volunteers. Serum levels tended to increase with metastatic progression and lymph node positivity. High serum Shh and IL-6 levels were associated with poor EFS and OS opposite to the negative or lower levels in serum Shh and IL-6. The elevated levels of both serum Shh and IL-6 were mainly observed in BC patients who had a significantly higher risk of early recurrence and bone metastasis, and associated with a worse survival for patients with progressive metastatic BC. Further studies are warranted for validating these biomarkers as prognostic tools in a larger patient cohort and in a longer follow-up study.A. S. NomanM. UddinA. A. ChowdhuryM. J. NayeemZ. RaihanM. I. RashidA. K. AzadM. L. RahmanD. BaruaA. SultanaA. ShirinJ. FerdousR. R. ParagS. M. RahmanM. R. MahmudC. S. JerinN. JahanA. SiddiquaT. AraE. B. SaburS. S. AlamS. BaidyaS. AktherM. Z. RahmanT. BanuA. K. MuruganS. SabriS. M. S. IslamB. KarakasA. AboussekhraH. YegerW. A. FarhatS. S. IslamNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. S. Noman M. Uddin A. A. Chowdhury M. J. Nayeem Z. Raihan M. I. Rashid A. K. Azad M. L. Rahman D. Barua A. Sultana A. Shirin J. Ferdous R. R. Parag S. M. Rahman M. R. Mahmud C. S. Jerin N. Jahan A. Siddiqua T. Ara E. B. Sabur S. S. Alam S. Baidya S. Akther M. Z. Rahman T. Banu A. K. Murugan S. Sabri S. M. S. Islam B. Karakas A. Aboussekhra H. Yeger W. A. Farhat S. S. Islam Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer
description	Abstract Serum from one hundred and ten breast cancer patients and thirty healthy female volunteers, were prospectively collected and evaluated for serum levels of Shh and IL-6 using human Shh and IL-6 specific enzyme-linked immunoassays. All patients were regularly monitored for event free survival (EFS) and overall survival (OS). Overall outcome analysis was based on serum Shh and IL-6 levels. In patients with progressive metastatic BC, both serum Shh and IL-6 concentrations were elevated in 44% (29 of 65) and 63% (41 of 65) of patients, respectively, at a statistically significant level [Shh (p = 0.0001) and IL-6 (p = 0.0001)] compared to the low levels in healthy volunteers. Serum levels tended to increase with metastatic progression and lymph node positivity. High serum Shh and IL-6 levels were associated with poor EFS and OS opposite to the negative or lower levels in serum Shh and IL-6. The elevated levels of both serum Shh and IL-6 were mainly observed in BC patients who had a significantly higher risk of early recurrence and bone metastasis, and associated with a worse survival for patients with progressive metastatic BC. Further studies are warranted for validating these biomarkers as prognostic tools in a larger patient cohort and in a longer follow-up study.
format	article
author	A. S. Noman M. Uddin A. A. Chowdhury M. J. Nayeem Z. Raihan M. I. Rashid A. K. Azad M. L. Rahman D. Barua A. Sultana A. Shirin J. Ferdous R. R. Parag S. M. Rahman M. R. Mahmud C. S. Jerin N. Jahan A. Siddiqua T. Ara E. B. Sabur S. S. Alam S. Baidya S. Akther M. Z. Rahman T. Banu A. K. Murugan S. Sabri S. M. S. Islam B. Karakas A. Aboussekhra H. Yeger W. A. Farhat S. S. Islam
author_facet	A. S. Noman M. Uddin A. A. Chowdhury M. J. Nayeem Z. Raihan M. I. Rashid A. K. Azad M. L. Rahman D. Barua A. Sultana A. Shirin J. Ferdous R. R. Parag S. M. Rahman M. R. Mahmud C. S. Jerin N. Jahan A. Siddiqua T. Ara E. B. Sabur S. S. Alam S. Baidya S. Akther M. Z. Rahman T. Banu A. K. Murugan S. Sabri S. M. S. Islam B. Karakas A. Aboussekhra H. Yeger W. A. Farhat S. S. Islam
author_sort	A. S. Noman
title	Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer
title_short	Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer
title_full	Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer
title_fullStr	Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer
title_full_unstemmed	Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer
title_sort	serum sonic hedgehog (shh) and interleukin-(il-6) as dual prognostic biomarkers in progressive metastatic breast cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c51c6852ee1e41158865136280d53ecd
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Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer

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