Effect of Pharmacogenetic-Based Decision Support Tools in Improving Depression Outcomes: A Systematic Review

Shimaa Aboelbaha,1 Monica Zolezzi,2 Hazem Elewa2 1College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 2Clinical Pharmacy and Practice, College of Pharmacy, QU Health, Qatar University, Doha, QatarCorrespondence: Monica ZolezziCollege of Pharmacy, QU Health, Qatar University, Doha, QatarEm...

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Autores principales:	Aboelbaha S, Zolezzi M, Elewa H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	pharmacogenetic testing major depressive disorder clinical decision support antidepressant treatment response Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c51d94d60c2d4bd7be47583660bc5d36
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spelling	oai:doaj.org-article:c51d94d60c2d4bd7be47583660bc5d362021-12-02T16:27:21ZEffect of Pharmacogenetic-Based Decision Support Tools in Improving Depression Outcomes: A Systematic Review1178-2021https://doaj.org/article/c51d94d60c2d4bd7be47583660bc5d362021-07-01T00:00:00Zhttps://www.dovepress.com/effect-of-pharmacogenetic-based-decision-support-tools-in-improving-de-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Shimaa Aboelbaha,1 Monica Zolezzi,2 Hazem Elewa2 1College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 2Clinical Pharmacy and Practice, College of Pharmacy, QU Health, Qatar University, Doha, QatarCorrespondence: Monica ZolezziCollege of Pharmacy, QU Health, Qatar University, Doha, QatarEmail mzolezzi@qu.edu.qaObjective: Evidence supporting the utility of pharmacogenetic (PGX) tests in depression is scarce. The main objectives of this study were to summarize, update, and assess the quality of the available evidence regarding PGX testing in depression as well as estimating the impact of using PGX testing tools in depression outcomes in the Middle East/North Africa (MENA) region.Methodology: Scientific databases were systematically searched from inception to June 30, 2020 for systematic reviews and randomized controlled trials (RCTs) assessing the clinical utility of PGX tests in the treatment of depression. Meta-analyses only and RCTs that were included in eligible systematic reviews were excluded. The quality of the eligible studies was assessed using the Crowe Critical Appraisal Tool (CCAT).Results: Six systematic reviews and three RCTs met the inclusion criteria and were included in this study. The results of the systematic reviews provided weak evidence on the efficacy of PGX testing, especially in patients with moderate–severe depression at 8 weeks. In addition, there was a lack of evidence regarding safety outcomes. Newer RCTs with better quality showed clinical promise regarding efficacy outcomes, especially in patients with gene–drug interactions. No evidence was found regarding PGX testing impact in the MENA region.Conclusion: This systematic review is an update and summary of the available literature on the clinical utility of PGX testing in depression. The findings of this study demonstrate that PGX testing prior to treatment initiation or during the course of therapy may improve efficacy outcomes. Further studies are warranted to assess the impact of PGX testing on safety outcomes.Keywords: pharmacogenetic testing, major depressive disorder, clinical decision support, antidepressant treatment responseAboelbaha SZolezzi MElewa HDove Medical Pressarticlepharmacogenetic testingmajor depressive disorderclinical decision supportantidepressant treatment responseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 2397-2419 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pharmacogenetic testing major depressive disorder clinical decision support antidepressant treatment response Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	pharmacogenetic testing major depressive disorder clinical decision support antidepressant treatment response Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Aboelbaha S Zolezzi M Elewa H Effect of Pharmacogenetic-Based Decision Support Tools in Improving Depression Outcomes: A Systematic Review
description	Shimaa Aboelbaha,1 Monica Zolezzi,2 Hazem Elewa2 1College of Pharmacy, QU Health, Qatar University, Doha, Qatar; 2Clinical Pharmacy and Practice, College of Pharmacy, QU Health, Qatar University, Doha, QatarCorrespondence: Monica ZolezziCollege of Pharmacy, QU Health, Qatar University, Doha, QatarEmail mzolezzi@qu.edu.qaObjective: Evidence supporting the utility of pharmacogenetic (PGX) tests in depression is scarce. The main objectives of this study were to summarize, update, and assess the quality of the available evidence regarding PGX testing in depression as well as estimating the impact of using PGX testing tools in depression outcomes in the Middle East/North Africa (MENA) region.Methodology: Scientific databases were systematically searched from inception to June 30, 2020 for systematic reviews and randomized controlled trials (RCTs) assessing the clinical utility of PGX tests in the treatment of depression. Meta-analyses only and RCTs that were included in eligible systematic reviews were excluded. The quality of the eligible studies was assessed using the Crowe Critical Appraisal Tool (CCAT).Results: Six systematic reviews and three RCTs met the inclusion criteria and were included in this study. The results of the systematic reviews provided weak evidence on the efficacy of PGX testing, especially in patients with moderate–severe depression at 8 weeks. In addition, there was a lack of evidence regarding safety outcomes. Newer RCTs with better quality showed clinical promise regarding efficacy outcomes, especially in patients with gene–drug interactions. No evidence was found regarding PGX testing impact in the MENA region.Conclusion: This systematic review is an update and summary of the available literature on the clinical utility of PGX testing in depression. The findings of this study demonstrate that PGX testing prior to treatment initiation or during the course of therapy may improve efficacy outcomes. Further studies are warranted to assess the impact of PGX testing on safety outcomes.Keywords: pharmacogenetic testing, major depressive disorder, clinical decision support, antidepressant treatment response
format	article
author	Aboelbaha S Zolezzi M Elewa H
author_facet	Aboelbaha S Zolezzi M Elewa H
author_sort	Aboelbaha S
title	Effect of Pharmacogenetic-Based Decision Support Tools in Improving Depression Outcomes: A Systematic Review
title_short	Effect of Pharmacogenetic-Based Decision Support Tools in Improving Depression Outcomes: A Systematic Review
title_full	Effect of Pharmacogenetic-Based Decision Support Tools in Improving Depression Outcomes: A Systematic Review
title_fullStr	Effect of Pharmacogenetic-Based Decision Support Tools in Improving Depression Outcomes: A Systematic Review
title_full_unstemmed	Effect of Pharmacogenetic-Based Decision Support Tools in Improving Depression Outcomes: A Systematic Review
title_sort	effect of pharmacogenetic-based decision support tools in improving depression outcomes: a systematic review
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c51d94d60c2d4bd7be47583660bc5d36
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Effect of Pharmacogenetic-Based Decision Support Tools in Improving Depression Outcomes: A Systematic Review

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