Advances in Injectable In Situ-Forming Hydrogels for Intratumoral Treatment

Chemotherapy has been linked to a variety of severe side effects, and the bioavailability of current chemotherapeutic agents is generally low, which decreases their effectiveness. Therefore, there is an ongoing effort to develop drug delivery systems to increase the bioavailability of these agents a...

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Autores principales:	Gi Ru Shin, Hee Eun Kim, Jae Ho Kim, Sangdun Choi, Moon Suk Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer intratumoral injection injectable in situ-forming hydrogel anticancer effect Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/c51dc698aa3c42abafba8a376ca8afed
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spelling	oai:doaj.org-article:c51dc698aa3c42abafba8a376ca8afed2021-11-25T18:42:20ZAdvances in Injectable In Situ-Forming Hydrogels for Intratumoral Treatment10.3390/pharmaceutics131119531999-4923https://doaj.org/article/c51dc698aa3c42abafba8a376ca8afed2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1953https://doaj.org/toc/1999-4923Chemotherapy has been linked to a variety of severe side effects, and the bioavailability of current chemotherapeutic agents is generally low, which decreases their effectiveness. Therefore, there is an ongoing effort to develop drug delivery systems to increase the bioavailability of these agents and minimize their side effects. Among these, intratumoral injections using in situ-forming hydrogels can improve drugs’ bioavailability and minimize drugs’ accumulation in non-target organs or tissues. This review describes different types of injectable in situ-forming hydrogels and their intratumoral injection for cancer treatment, after which we discuss the antitumor effects of intratumoral injection of drug-loaded hydrogels. This review concludes with perspectives on the future applicability of, and challenges for, the adoption of this drug delivery technology.Gi Ru ShinHee Eun KimJae Ho KimSangdun ChoiMoon Suk KimMDPI AGarticlecancerintratumoral injectioninjectable in situ-forming hydrogelanticancer effectPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1953, p 1953 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer intratumoral injection injectable in situ-forming hydrogel anticancer effect Pharmacy and materia medica RS1-441
spellingShingle	cancer intratumoral injection injectable in situ-forming hydrogel anticancer effect Pharmacy and materia medica RS1-441 Gi Ru Shin Hee Eun Kim Jae Ho Kim Sangdun Choi Moon Suk Kim Advances in Injectable In Situ-Forming Hydrogels for Intratumoral Treatment
description	Chemotherapy has been linked to a variety of severe side effects, and the bioavailability of current chemotherapeutic agents is generally low, which decreases their effectiveness. Therefore, there is an ongoing effort to develop drug delivery systems to increase the bioavailability of these agents and minimize their side effects. Among these, intratumoral injections using in situ-forming hydrogels can improve drugs’ bioavailability and minimize drugs’ accumulation in non-target organs or tissues. This review describes different types of injectable in situ-forming hydrogels and their intratumoral injection for cancer treatment, after which we discuss the antitumor effects of intratumoral injection of drug-loaded hydrogels. This review concludes with perspectives on the future applicability of, and challenges for, the adoption of this drug delivery technology.
format	article
author	Gi Ru Shin Hee Eun Kim Jae Ho Kim Sangdun Choi Moon Suk Kim
author_facet	Gi Ru Shin Hee Eun Kim Jae Ho Kim Sangdun Choi Moon Suk Kim
author_sort	Gi Ru Shin
title	Advances in Injectable In Situ-Forming Hydrogels for Intratumoral Treatment
title_short	Advances in Injectable In Situ-Forming Hydrogels for Intratumoral Treatment
title_full	Advances in Injectable In Situ-Forming Hydrogels for Intratumoral Treatment
title_fullStr	Advances in Injectable In Situ-Forming Hydrogels for Intratumoral Treatment
title_full_unstemmed	Advances in Injectable In Situ-Forming Hydrogels for Intratumoral Treatment
title_sort	advances in injectable in situ-forming hydrogels for intratumoral treatment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c51dc698aa3c42abafba8a376ca8afed
work_keys_str_mv	AT girushin advancesininjectableinsituforminghydrogelsforintratumoraltreatment AT heeeunkim advancesininjectableinsituforminghydrogelsforintratumoraltreatment AT jaehokim advancesininjectableinsituforminghydrogelsforintratumoraltreatment AT sangdunchoi advancesininjectableinsituforminghydrogelsforintratumoraltreatment AT moonsukkim advancesininjectableinsituforminghydrogelsforintratumoraltreatment
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Advances in Injectable In Situ-Forming Hydrogels for Intratumoral Treatment

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