Successful Experience of Fecal Transplantation in a Patient with Severe Pseudomembranous Colitis

Introduction. At the present time there is increase the number of patients diagnosed with pseudomembranous colitis due to Clostridiodes difficile, respectively it significantly increases the frequency of hospitalizations, the length of hospital stay and the cost of treatment. Approved drug methods f...

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Autores principales:	L. R. Shedoeva, E. Yu. Chashkova, A. S. Rubtsov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	clostridiodes difficile pseudomembranous colitis fecal microbiota transplantation colonoscopy Science Q
Acceso en línea:	https://doaj.org/article/c51dd4b75da24943a4a3ec8a2c2ea2fb
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spelling	oai:doaj.org-article:c51dd4b75da24943a4a3ec8a2c2ea2fb2021-11-23T06:14:45ZSuccessful Experience of Fecal Transplantation in a Patient with Severe Pseudomembranous Colitis2541-94202587-959610.29413/ABS.2020-5.6.32https://doaj.org/article/c51dd4b75da24943a4a3ec8a2c2ea2fb2021-01-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2523https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Introduction. At the present time there is increase the number of patients diagnosed with pseudomembranous colitis due to Clostridiodes difficile, respectively it significantly increases the frequency of hospitalizations, the length of hospital stay and the cost of treatment. Approved drug methods for correcting a pathological condition are not always able to lead to recovery after the first use, repeated and prolonged courses of therapy are often required, especially with recurrent Clostridiodes difficile. An alternative way of treatment is fecal microbiota transplantation from a donor. Nowadays, fecal microbiota transplantation is included in national clinical guidelines in several countries in Europe, the USA and Australia. In Russia this method has not been registered, however, there are some publications about its successful application in gastrointestinal diseases, oncohematology, and some autoimmune diseases. Aim. To show the result of successful treatment of severe pseudomembranous colitis after a single fecal microbiota transplantation.Material and methods. Outpatient treatment of an acute respiratory infection with a broad-spectrum antibacterial drug caused the development of severe pseudomembranous colitis in a young patient. Standard courses of metronidazole and vancomycin were unsuccessful. Transplantation of fecal microbiota from a donor was performed via ileocolonoscopy.Results. A single fecal microbiota transplantation contributed to the patient’s complete recovery, short term rehabilitation and the absence of recurrence of Clostridiodes difficile within two years. Conclusions. Evidence-based medicine has shown the high efficiency of fecal microbiota transplantation. In Russia a legislative basis is needed for including fecal microbiota transplantation in clinical guidelines for the treatment of severe Clostridiodes difficile resistant to standard therapy.L. R. ShedoevaE. Yu. ChashkovaA. S. RubtsovScientific Сentre for Family Health and Human Reproduction Problemsarticleclostridiodes difficilepseudomembranous colitisfecal microbiota transplantationcolonoscopyScienceQRUActa Biomedica Scientifica, Vol 5, Iss 6, Pp 248-253 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	clostridiodes difficile pseudomembranous colitis fecal microbiota transplantation colonoscopy Science Q
spellingShingle	clostridiodes difficile pseudomembranous colitis fecal microbiota transplantation colonoscopy Science Q L. R. Shedoeva E. Yu. Chashkova A. S. Rubtsov Successful Experience of Fecal Transplantation in a Patient with Severe Pseudomembranous Colitis
description	Introduction. At the present time there is increase the number of patients diagnosed with pseudomembranous colitis due to Clostridiodes difficile, respectively it significantly increases the frequency of hospitalizations, the length of hospital stay and the cost of treatment. Approved drug methods for correcting a pathological condition are not always able to lead to recovery after the first use, repeated and prolonged courses of therapy are often required, especially with recurrent Clostridiodes difficile. An alternative way of treatment is fecal microbiota transplantation from a donor. Nowadays, fecal microbiota transplantation is included in national clinical guidelines in several countries in Europe, the USA and Australia. In Russia this method has not been registered, however, there are some publications about its successful application in gastrointestinal diseases, oncohematology, and some autoimmune diseases. Aim. To show the result of successful treatment of severe pseudomembranous colitis after a single fecal microbiota transplantation.Material and methods. Outpatient treatment of an acute respiratory infection with a broad-spectrum antibacterial drug caused the development of severe pseudomembranous colitis in a young patient. Standard courses of metronidazole and vancomycin were unsuccessful. Transplantation of fecal microbiota from a donor was performed via ileocolonoscopy.Results. A single fecal microbiota transplantation contributed to the patient’s complete recovery, short term rehabilitation and the absence of recurrence of Clostridiodes difficile within two years. Conclusions. Evidence-based medicine has shown the high efficiency of fecal microbiota transplantation. In Russia a legislative basis is needed for including fecal microbiota transplantation in clinical guidelines for the treatment of severe Clostridiodes difficile resistant to standard therapy.
format	article
author	L. R. Shedoeva E. Yu. Chashkova A. S. Rubtsov
author_facet	L. R. Shedoeva E. Yu. Chashkova A. S. Rubtsov
author_sort	L. R. Shedoeva
title	Successful Experience of Fecal Transplantation in a Patient with Severe Pseudomembranous Colitis
title_short	Successful Experience of Fecal Transplantation in a Patient with Severe Pseudomembranous Colitis
title_full	Successful Experience of Fecal Transplantation in a Patient with Severe Pseudomembranous Colitis
title_fullStr	Successful Experience of Fecal Transplantation in a Patient with Severe Pseudomembranous Colitis
title_full_unstemmed	Successful Experience of Fecal Transplantation in a Patient with Severe Pseudomembranous Colitis
title_sort	successful experience of fecal transplantation in a patient with severe pseudomembranous colitis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/c51dd4b75da24943a4a3ec8a2c2ea2fb
work_keys_str_mv	AT lrshedoeva successfulexperienceoffecaltransplantationinapatientwithseverepseudomembranouscolitis AT eyuchashkova successfulexperienceoffecaltransplantationinapatientwithseverepseudomembranouscolitis AT asrubtsov successfulexperienceoffecaltransplantationinapatientwithseverepseudomembranouscolitis
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Successful Experience of Fecal Transplantation in a Patient with Severe Pseudomembranous Colitis

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