Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy

Nucleic acid nanomedicines are promising for cancer drug delivery. Here, the authors show using a mouse model the tumor immunotherapeutic efficacy of nanovaccines based on intertwining DNA-RNA nanocapsules loaded with DNA CpG, Stat3-silencing short hairpin RNA and tumor-specific peptide neoantigens.

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Autores principales:	Guizhi Zhu, Lei Mei, Harshad D. Vishwasrao, Orit Jacobson, Zhantong Wang, Yijing Liu, Bryant C. Yung, Xiao Fu, Albert Jin, Gang Niu, Qin Wang, Fuwu Zhang, Hari Shroff, Xiaoyuan Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c51e8ed297cd4c9da385abee4fc19f46
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:c51e8ed297cd4c9da385abee4fc19f462021-12-02T14:41:21ZIntertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy10.1038/s41467-017-01386-72041-1723https://doaj.org/article/c51e8ed297cd4c9da385abee4fc19f462017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01386-7https://doaj.org/toc/2041-1723Nucleic acid nanomedicines are promising for cancer drug delivery. Here, the authors show using a mouse model the tumor immunotherapeutic efficacy of nanovaccines based on intertwining DNA-RNA nanocapsules loaded with DNA CpG, Stat3-silencing short hairpin RNA and tumor-specific peptide neoantigens.Guizhi ZhuLei MeiHarshad D. VishwasraoOrit JacobsonZhantong WangYijing LiuBryant C. YungXiao FuAlbert JinGang NiuQin WangFuwu ZhangHari ShroffXiaoyuan ChenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guizhi Zhu Lei Mei Harshad D. Vishwasrao Orit Jacobson Zhantong Wang Yijing Liu Bryant C. Yung Xiao Fu Albert Jin Gang Niu Qin Wang Fuwu Zhang Hari Shroff Xiaoyuan Chen Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy
description	Nucleic acid nanomedicines are promising for cancer drug delivery. Here, the authors show using a mouse model the tumor immunotherapeutic efficacy of nanovaccines based on intertwining DNA-RNA nanocapsules loaded with DNA CpG, Stat3-silencing short hairpin RNA and tumor-specific peptide neoantigens.
format	article
author	Guizhi Zhu Lei Mei Harshad D. Vishwasrao Orit Jacobson Zhantong Wang Yijing Liu Bryant C. Yung Xiao Fu Albert Jin Gang Niu Qin Wang Fuwu Zhang Hari Shroff Xiaoyuan Chen
author_facet	Guizhi Zhu Lei Mei Harshad D. Vishwasrao Orit Jacobson Zhantong Wang Yijing Liu Bryant C. Yung Xiao Fu Albert Jin Gang Niu Qin Wang Fuwu Zhang Hari Shroff Xiaoyuan Chen
author_sort	Guizhi Zhu
title	Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy
title_short	Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy
title_full	Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy
title_fullStr	Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy
title_full_unstemmed	Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy
title_sort	intertwining dna-rna nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c51e8ed297cd4c9da385abee4fc19f46
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Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy

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