PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments

The inactive X (Xi)-specific S1/S2 chromosome compartments are merged by SMCHD1, but how the S1/S2 structure is constructed is unclear. The authors find that PRC1 drives the formation of S1/S2s and that the stepwise folding process of the Xi facilitates Xist RNA spreading between Xi compartments.

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Autores principales:	Chen-Yu Wang, David Colognori, Hongjae Sunwoo, Danni Wang, Jeannie T. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c522349fbe6a426a81a63a1854f919b4
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spelling	oai:doaj.org-article:c522349fbe6a426a81a63a1854f919b42021-12-02T17:01:28ZPRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments10.1038/s41467-019-10755-32041-1723https://doaj.org/article/c522349fbe6a426a81a63a1854f919b42019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10755-3https://doaj.org/toc/2041-1723The inactive X (Xi)-specific S1/S2 chromosome compartments are merged by SMCHD1, but how the S1/S2 structure is constructed is unclear. The authors find that PRC1 drives the formation of S1/S2s and that the stepwise folding process of the Xi facilitates Xist RNA spreading between Xi compartments.Chen-Yu WangDavid ColognoriHongjae SunwooDanni WangJeannie T. LeeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chen-Yu Wang David Colognori Hongjae Sunwoo Danni Wang Jeannie T. Lee PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments
description	The inactive X (Xi)-specific S1/S2 chromosome compartments are merged by SMCHD1, but how the S1/S2 structure is constructed is unclear. The authors find that PRC1 drives the formation of S1/S2s and that the stepwise folding process of the Xi facilitates Xist RNA spreading between Xi compartments.
format	article
author	Chen-Yu Wang David Colognori Hongjae Sunwoo Danni Wang Jeannie T. Lee
author_facet	Chen-Yu Wang David Colognori Hongjae Sunwoo Danni Wang Jeannie T. Lee
author_sort	Chen-Yu Wang
title	PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments
title_short	PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments
title_full	PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments
title_fullStr	PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments
title_full_unstemmed	PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments
title_sort	prc1 collaborates with smchd1 to fold the x-chromosome and spread xist rna between chromosome compartments
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c522349fbe6a426a81a63a1854f919b4
work_keys_str_mv	AT chenyuwang prc1collaborateswithsmchd1tofoldthexchromosomeandspreadxistrnabetweenchromosomecompartments AT davidcolognori prc1collaborateswithsmchd1tofoldthexchromosomeandspreadxistrnabetweenchromosomecompartments AT hongjaesunwoo prc1collaborateswithsmchd1tofoldthexchromosomeandspreadxistrnabetweenchromosomecompartments AT danniwang prc1collaborateswithsmchd1tofoldthexchromosomeandspreadxistrnabetweenchromosomecompartments AT jeannietlee prc1collaborateswithsmchd1tofoldthexchromosomeandspreadxistrnabetweenchromosomecompartments
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PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments

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