Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses

Swetha Rajasekaran et al. integrate transcriptional, proteomic, and metabolomic data to explore how cells adapt to inactivation of RB1, a hallmark of cancer. Combined with their genetic analyses in a Drosophila model, the authors identify key metabolic pathways that may be involved in the growth of...

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Autores principales:	Swetha Rajasekaran, Jalal Siddiqui, Jessica Rakijas, Brandon Nicolay, Chenyu Lin, Eshan Khan, Rahi Patel, Robert Morris, Emanuel Wyler, Myriam Boukhali, Jayashree Balasubramanyam, R. Ranjith Kumar, Capucine Van Rechem, Christine Vogel, Sailaja V. Elchuri, Markus Landthaler, Benedikt Obermayer, Wilhelm Haas, Nicholas Dyson, Wayne Miles
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c522d3a225e8419ab1ce5e0411f3ed84
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spelling	oai:doaj.org-article:c522d3a225e8419ab1ce5e0411f3ed842021-12-02T17:08:22ZIntegrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses10.1038/s42003-021-02495-22399-3642https://doaj.org/article/c522d3a225e8419ab1ce5e0411f3ed842021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02495-2https://doaj.org/toc/2399-3642Swetha Rajasekaran et al. integrate transcriptional, proteomic, and metabolomic data to explore how cells adapt to inactivation of RB1, a hallmark of cancer. Combined with their genetic analyses in a Drosophila model, the authors identify key metabolic pathways that may be involved in the growth of RB1-depleted cancer cells.Swetha RajasekaranJalal SiddiquiJessica RakijasBrandon NicolayChenyu LinEshan KhanRahi PatelRobert MorrisEmanuel WylerMyriam BoukhaliJayashree BalasubramanyamR. Ranjith KumarCapucine Van RechemChristine VogelSailaja V. ElchuriMarkus LandthalerBenedikt ObermayerWilhelm HaasNicholas DysonWayne MilesNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Swetha Rajasekaran Jalal Siddiqui Jessica Rakijas Brandon Nicolay Chenyu Lin Eshan Khan Rahi Patel Robert Morris Emanuel Wyler Myriam Boukhali Jayashree Balasubramanyam R. Ranjith Kumar Capucine Van Rechem Christine Vogel Sailaja V. Elchuri Markus Landthaler Benedikt Obermayer Wilhelm Haas Nicholas Dyson Wayne Miles Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses
description	Swetha Rajasekaran et al. integrate transcriptional, proteomic, and metabolomic data to explore how cells adapt to inactivation of RB1, a hallmark of cancer. Combined with their genetic analyses in a Drosophila model, the authors identify key metabolic pathways that may be involved in the growth of RB1-depleted cancer cells.
format	article
author	Swetha Rajasekaran Jalal Siddiqui Jessica Rakijas Brandon Nicolay Chenyu Lin Eshan Khan Rahi Patel Robert Morris Emanuel Wyler Myriam Boukhali Jayashree Balasubramanyam R. Ranjith Kumar Capucine Van Rechem Christine Vogel Sailaja V. Elchuri Markus Landthaler Benedikt Obermayer Wilhelm Haas Nicholas Dyson Wayne Miles
author_facet	Swetha Rajasekaran Jalal Siddiqui Jessica Rakijas Brandon Nicolay Chenyu Lin Eshan Khan Rahi Patel Robert Morris Emanuel Wyler Myriam Boukhali Jayashree Balasubramanyam R. Ranjith Kumar Capucine Van Rechem Christine Vogel Sailaja V. Elchuri Markus Landthaler Benedikt Obermayer Wilhelm Haas Nicholas Dyson Wayne Miles
author_sort	Swetha Rajasekaran
title	Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses
title_short	Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses
title_full	Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses
title_fullStr	Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses
title_full_unstemmed	Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses
title_sort	integrated multi-omics analysis of rb-loss identifies widespread cellular programming and synthetic weaknesses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c522d3a225e8419ab1ce5e0411f3ed84
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Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses

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