Aggregation activity of blood formed elements in patients with type 1 and type 2 diabetes mellitus

Aims. To assess differences in blood formed elements aggregation activity in patients with type 1 (T1) and type 2 (T2) diabetes mellitus(DM). Materials and methods. We studied blood samples from 88 patients with T1 and T2 DM. Platelet aggregation activity was assessed bymeans of ?Biola? aggregomet...

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Autores principales:	Boris Il'ich Kuznik, Yury Antonovich Vitkovskiy, Marina Yur'evna Zakharova, Natalya Nikolaevna Klyuchereva, Olga Sergeevna Rodnina, Aleksey Vladimirovich Solpov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2012
Materias:	platelets leukocytes lymphocytes erythrocytes aggregation adhesion diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/c52322a2ed554035b95ab889ccdd68ed
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spelling	oai:doaj.org-article:c52322a2ed554035b95ab889ccdd68ed2021-11-14T09:00:17ZAggregation activity of blood formed elements in patients with type 1 and type 2 diabetes mellitus2072-03512072-037810.14341/2072-0351-5518https://doaj.org/article/c52322a2ed554035b95ab889ccdd68ed2012-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5518https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aims. To assess differences in blood formed elements aggregation activity in patients with type 1 (T1) and type 2 (T2) diabetes mellitus(DM). Materials and methods. We studied blood samples from 88 patients with T1 and T2 DM. Platelet aggregation activity was assessed bymeans of ?Biola? aggregometer; we also determined platelet-lymphocyte and leucocyte-erythrocyte adhesion intensity. Results. We show that spontaneous platelet aggregation is markedly increased in patients with T1DM but remains normal or slightlyelevated in case of T2DM. In blood from patients with T2DM platelet aggregation in response to ADP, epinephrine, ristomycineand contact with collagen was generally increased, whereas in T1DM we often observed its secondary reduction. Data on plateletlymphocyteadhesion in T1DM is controversial, but in T2DM this process seems to be significantly suppressed. Quantity of leucocyteerythrocyteaggregates was sharply increased in both T1DM and T2DM. Conclusion. We've determined significant difference in blood formed elements aggregation activity between patients with T1 and T2 DM.Boris Il'ich KuznikYury Antonovich VitkovskiyMarina Yur'evna ZakharovaNatalya Nikolaevna KlyucherevaOlga Sergeevna RodninaAleksey Vladimirovich SolpovEndocrinology Research Centrearticleplateletsleukocyteslymphocyteserythrocytesaggregationadhesiondiabetes mellitusNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 15, Iss 2, Pp 49-53 (2012)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	platelets leukocytes lymphocytes erythrocytes aggregation adhesion diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	platelets leukocytes lymphocytes erythrocytes aggregation adhesion diabetes mellitus Nutritional diseases. Deficiency diseases RC620-627 Boris Il'ich Kuznik Yury Antonovich Vitkovskiy Marina Yur'evna Zakharova Natalya Nikolaevna Klyuchereva Olga Sergeevna Rodnina Aleksey Vladimirovich Solpov Aggregation activity of blood formed elements in patients with type 1 and type 2 diabetes mellitus
description	Aims. To assess differences in blood formed elements aggregation activity in patients with type 1 (T1) and type 2 (T2) diabetes mellitus(DM). Materials and methods. We studied blood samples from 88 patients with T1 and T2 DM. Platelet aggregation activity was assessed bymeans of ?Biola? aggregometer; we also determined platelet-lymphocyte and leucocyte-erythrocyte adhesion intensity. Results. We show that spontaneous platelet aggregation is markedly increased in patients with T1DM but remains normal or slightlyelevated in case of T2DM. In blood from patients with T2DM platelet aggregation in response to ADP, epinephrine, ristomycineand contact with collagen was generally increased, whereas in T1DM we often observed its secondary reduction. Data on plateletlymphocyteadhesion in T1DM is controversial, but in T2DM this process seems to be significantly suppressed. Quantity of leucocyteerythrocyteaggregates was sharply increased in both T1DM and T2DM. Conclusion. We've determined significant difference in blood formed elements aggregation activity between patients with T1 and T2 DM.
format	article
author	Boris Il'ich Kuznik Yury Antonovich Vitkovskiy Marina Yur'evna Zakharova Natalya Nikolaevna Klyuchereva Olga Sergeevna Rodnina Aleksey Vladimirovich Solpov
author_facet	Boris Il'ich Kuznik Yury Antonovich Vitkovskiy Marina Yur'evna Zakharova Natalya Nikolaevna Klyuchereva Olga Sergeevna Rodnina Aleksey Vladimirovich Solpov
author_sort	Boris Il'ich Kuznik
title	Aggregation activity of blood formed elements in patients with type 1 and type 2 diabetes mellitus
title_short	Aggregation activity of blood formed elements in patients with type 1 and type 2 diabetes mellitus
title_full	Aggregation activity of blood formed elements in patients with type 1 and type 2 diabetes mellitus
title_fullStr	Aggregation activity of blood formed elements in patients with type 1 and type 2 diabetes mellitus
title_full_unstemmed	Aggregation activity of blood formed elements in patients with type 1 and type 2 diabetes mellitus
title_sort	aggregation activity of blood formed elements in patients with type 1 and type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2012
url	https://doaj.org/article/c52322a2ed554035b95ab889ccdd68ed
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Aggregation activity of blood formed elements in patients with type 1 and type 2 diabetes mellitus

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