Correlation Between Hemoglobin Glycosylation Index and Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus

Zelin Li,1,2 Yuan Gao,3 Yujiao Jia,1,2 Shuchun Chen1,2,4 1Graduate School of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China; 3Shijiazhuang 16th Retired Cadre Rest Center...

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Autores principales:	Li Z, Gao Y, Jia Y, Chen S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	hemoglobin glycation variation index peripheral nerve conduction velocity type 2 diabetes mellitus Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/c52596fea1ea4342a6574283f4ca9e0e
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spelling	oai:doaj.org-article:c52596fea1ea4342a6574283f4ca9e0e2021-12-05T18:27:45ZCorrelation Between Hemoglobin Glycosylation Index and Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus1178-7007https://doaj.org/article/c52596fea1ea4342a6574283f4ca9e0e2021-12-01T00:00:00Zhttps://www.dovepress.com/correlation-between-hemoglobin-glycosylation-index-and-nerve-conductio-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Zelin Li,1,2 Yuan Gao,3 Yujiao Jia,1,2 Shuchun Chen1,2,4 1Graduate School of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China; 3Shijiazhuang 16th Retired Cadre Rest Center of Hebei Military Region, Shijiazhuang, Hebei, People’s Republic of China; 4Hebei Key Laboratory of Metabolic Diseases, Shijiazhuang, Hebei, People’s Republic of ChinaCorrespondence: Shuchun ChenDepartment of Endocrinology, Hebei General Hospital, 348 Heping West Road, Shijiazhuang, Hebei, 050051, People’s Republic of ChinaTel/Fax +86 311 85988406Email chenshuc2014@163.comObjective: This study aimed to investigate the relationship between hemoglobin glycation variation index (HGI) and peripheral nerve conduction velocity (NCV) in patients with type 2 diabetes mellitus (T2DM).Materials and Methods: This is a cross-sectional study, including 324 patients with T2DM were included in this study. Basic information and blood indicators were collected. The motor conduction velocities (MCV) of the bilateral ulnar nerve, median nerve, and common peroneal nerve, and the sensory conduction velocities (SCV) of the ulnar nerve, median nerve, and superficial peroneal nerve were measured. The patients were divided into two groups according to the NCV: normal nerve conduction group (NCVN group) and abnormal nerve conduction group (NCVA group). When the NCV is less than the specific normal value, the patients were divided into the NCVA group. HGI was calculated as the difference between the measured and predicted values of glycosylated hemoglobin (HbA1c) using the linear relationship between HbA1c level and fasting plasma glucose levels. At last, all study participants were divided into High HGI and Low HGI groups using the median of HGI as the boundary. The study also analyzed the correlation between HGI and NCV.Results: Compared to the NCVN group, the HGI levels of the NCVA group were higher (P < 0.001). The prevalence of NCVA in the high HGI group was higher than that in the low HGI group (P = 0.004). HGI was negatively correlated with bilateral ulnar nerve MCV, bilateral median nerve MCV, bilateral common peroneal nerve MCV, bilateral median nerve SCV and left superficial peroneal nerve SCV, and the correlation still existed after adjusting for confounding factors.Conclusion: This study found that HGI is inversely associated with NCV in patients with T2DM, and this correlation is higher between HGI and MCV of peripheral nerve.Keywords: hemoglobin glycation variation index, peripheral nerve conduction velocity, type 2 diabetes mellitusLi ZGao YJia YChen SDove Medical Pressarticlehemoglobin glycation variation indexperipheral nerve conduction velocitytype 2 diabetes mellitusSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4757-4765 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hemoglobin glycation variation index peripheral nerve conduction velocity type 2 diabetes mellitus Specialties of internal medicine RC581-951
spellingShingle	hemoglobin glycation variation index peripheral nerve conduction velocity type 2 diabetes mellitus Specialties of internal medicine RC581-951 Li Z Gao Y Jia Y Chen S Correlation Between Hemoglobin Glycosylation Index and Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus
description	Zelin Li,1,2 Yuan Gao,3 Yujiao Jia,1,2 Shuchun Chen1,2,4 1Graduate School of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, Hebei, People’s Republic of China; 3Shijiazhuang 16th Retired Cadre Rest Center of Hebei Military Region, Shijiazhuang, Hebei, People’s Republic of China; 4Hebei Key Laboratory of Metabolic Diseases, Shijiazhuang, Hebei, People’s Republic of ChinaCorrespondence: Shuchun ChenDepartment of Endocrinology, Hebei General Hospital, 348 Heping West Road, Shijiazhuang, Hebei, 050051, People’s Republic of ChinaTel/Fax +86 311 85988406Email chenshuc2014@163.comObjective: This study aimed to investigate the relationship between hemoglobin glycation variation index (HGI) and peripheral nerve conduction velocity (NCV) in patients with type 2 diabetes mellitus (T2DM).Materials and Methods: This is a cross-sectional study, including 324 patients with T2DM were included in this study. Basic information and blood indicators were collected. The motor conduction velocities (MCV) of the bilateral ulnar nerve, median nerve, and common peroneal nerve, and the sensory conduction velocities (SCV) of the ulnar nerve, median nerve, and superficial peroneal nerve were measured. The patients were divided into two groups according to the NCV: normal nerve conduction group (NCVN group) and abnormal nerve conduction group (NCVA group). When the NCV is less than the specific normal value, the patients were divided into the NCVA group. HGI was calculated as the difference between the measured and predicted values of glycosylated hemoglobin (HbA1c) using the linear relationship between HbA1c level and fasting plasma glucose levels. At last, all study participants were divided into High HGI and Low HGI groups using the median of HGI as the boundary. The study also analyzed the correlation between HGI and NCV.Results: Compared to the NCVN group, the HGI levels of the NCVA group were higher (P < 0.001). The prevalence of NCVA in the high HGI group was higher than that in the low HGI group (P = 0.004). HGI was negatively correlated with bilateral ulnar nerve MCV, bilateral median nerve MCV, bilateral common peroneal nerve MCV, bilateral median nerve SCV and left superficial peroneal nerve SCV, and the correlation still existed after adjusting for confounding factors.Conclusion: This study found that HGI is inversely associated with NCV in patients with T2DM, and this correlation is higher between HGI and MCV of peripheral nerve.Keywords: hemoglobin glycation variation index, peripheral nerve conduction velocity, type 2 diabetes mellitus
format	article
author	Li Z Gao Y Jia Y Chen S
author_facet	Li Z Gao Y Jia Y Chen S
author_sort	Li Z
title	Correlation Between Hemoglobin Glycosylation Index and Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus
title_short	Correlation Between Hemoglobin Glycosylation Index and Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus
title_full	Correlation Between Hemoglobin Glycosylation Index and Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus
title_fullStr	Correlation Between Hemoglobin Glycosylation Index and Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus
title_full_unstemmed	Correlation Between Hemoglobin Glycosylation Index and Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus
title_sort	correlation between hemoglobin glycosylation index and nerve conduction velocity in patients with type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c52596fea1ea4342a6574283f4ca9e0e
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Correlation Between Hemoglobin Glycosylation Index and Nerve Conduction Velocity in Patients with Type 2 Diabetes Mellitus

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