An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria

Peptide antibiotics often display a very narrow therapeutic index. Here, the authors present an optimized peptide antibiotic with broad-spectrum in vitro activities, in vivo efficacy in multiple disease models against multidrug-resistant Gram-negative infections, and reduced toxicity.

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Autores principales:	Alysha G. Elliott, Johnny X. Huang, Søren Neve, Johannes Zuegg, Ingrid A. Edwards, Amy K. Cain, Christine J. Boinett, Lars Barquist, Carina Vingsbo Lundberg, Jason Steen, Mark S. Butler, Mehdi Mobli, Kaela M. Porter, Mark A. T. Blaskovich, Sergio Lociuro, Magnus Strandh, Matthew A. Cooper
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c52da634b87d440cbbc0c10a3c254c56
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spelling	oai:doaj.org-article:c52da634b87d440cbbc0c10a3c254c562021-12-02T17:45:10ZAn amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria10.1038/s41467-020-16950-x2041-1723https://doaj.org/article/c52da634b87d440cbbc0c10a3c254c562020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16950-xhttps://doaj.org/toc/2041-1723Peptide antibiotics often display a very narrow therapeutic index. Here, the authors present an optimized peptide antibiotic with broad-spectrum in vitro activities, in vivo efficacy in multiple disease models against multidrug-resistant Gram-negative infections, and reduced toxicity.Alysha G. ElliottJohnny X. HuangSøren NeveJohannes ZueggIngrid A. EdwardsAmy K. CainChristine J. BoinettLars BarquistCarina Vingsbo LundbergJason SteenMark S. ButlerMehdi MobliKaela M. PorterMark A. T. BlaskovichSergio LociuroMagnus StrandhMatthew A. CooperNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alysha G. Elliott Johnny X. Huang Søren Neve Johannes Zuegg Ingrid A. Edwards Amy K. Cain Christine J. Boinett Lars Barquist Carina Vingsbo Lundberg Jason Steen Mark S. Butler Mehdi Mobli Kaela M. Porter Mark A. T. Blaskovich Sergio Lociuro Magnus Strandh Matthew A. Cooper An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
description	Peptide antibiotics often display a very narrow therapeutic index. Here, the authors present an optimized peptide antibiotic with broad-spectrum in vitro activities, in vivo efficacy in multiple disease models against multidrug-resistant Gram-negative infections, and reduced toxicity.
format	article
author	Alysha G. Elliott Johnny X. Huang Søren Neve Johannes Zuegg Ingrid A. Edwards Amy K. Cain Christine J. Boinett Lars Barquist Carina Vingsbo Lundberg Jason Steen Mark S. Butler Mehdi Mobli Kaela M. Porter Mark A. T. Blaskovich Sergio Lociuro Magnus Strandh Matthew A. Cooper
author_facet	Alysha G. Elliott Johnny X. Huang Søren Neve Johannes Zuegg Ingrid A. Edwards Amy K. Cain Christine J. Boinett Lars Barquist Carina Vingsbo Lundberg Jason Steen Mark S. Butler Mehdi Mobli Kaela M. Porter Mark A. T. Blaskovich Sergio Lociuro Magnus Strandh Matthew A. Cooper
author_sort	Alysha G. Elliott
title	An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
title_short	An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
title_full	An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
title_fullStr	An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
title_full_unstemmed	An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
title_sort	amphipathic peptide with antibiotic activity against multidrug-resistant gram-negative bacteria
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c52da634b87d440cbbc0c10a3c254c56
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An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria

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