An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
Peptide antibiotics often display a very narrow therapeutic index. Here, the authors present an optimized peptide antibiotic with broad-spectrum in vitro activities, in vivo efficacy in multiple disease models against multidrug-resistant Gram-negative infections, and reduced toxicity.
Guardado en:
Autores principales: | Alysha G. Elliott, Johnny X. Huang, Søren Neve, Johannes Zuegg, Ingrid A. Edwards, Amy K. Cain, Christine J. Boinett, Lars Barquist, Carina Vingsbo Lundberg, Jason Steen, Mark S. Butler, Mehdi Mobli, Kaela M. Porter, Mark A. T. Blaskovich, Sergio Lociuro, Magnus Strandh, Matthew A. Cooper |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/c52da634b87d440cbbc0c10a3c254c56 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
New Multidrug Efflux Inhibitors for Gram-Negative Bacteria
por: Robert L. Marshall, et al.
Publicado: (2020) -
The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation.
por: Chai Ann Ng, et al.
Publicado: (2011) -
Prevalence and characterisation of carbapenemase encoding genes in multidrug-resistant Gram-negative bacilli.
por: Sayran Hamad Haji, et al.
Publicado: (2021) -
Prevalence and characterisation of carbapenemase encoding genes in multidrug-resistant Gram-negative bacilli
por: Sayran Hamad Haji, et al.
Publicado: (2021) -
INTERMOLECULAR ASSOCIATION OF AMPHIPATHIC POLYELECTROLYTES IN AQUEOUS SOLUTIONS
por: RÍOS,HERNÁN E, et al.
Publicado: (2016)