Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis

Abstract To evaluate extralesional microvascular and structural changes of the macula using optical coherence tomography angiography (OCTA) and structural OCT in cytomegalovirus retinitis (CMVR). An observational study of CMVR patients were performed. Complete ophthalmic examination, serial color fu...

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Autores principales:	Nida Wongchaisuwat, Sansanee Khongpipatchaisiri, Sutasinee Boonsopon, Pitipol Choopong, Nattaporn Tesavibul, Supalert Prakhunhungsit, Somanus Thoongsuwan, Nuttawut Rodanant, Nopasak Phasukkijwatana
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c52e4330a059474db2410fd331ef1f98
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spelling	oai:doaj.org-article:c52e4330a059474db2410fd331ef1f982021-12-02T16:18:03ZExtralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis10.1038/s41598-020-78587-62045-2322https://doaj.org/article/c52e4330a059474db2410fd331ef1f982020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78587-6https://doaj.org/toc/2045-2322Abstract To evaluate extralesional microvascular and structural changes of the macula using optical coherence tomography angiography (OCTA) and structural OCT in cytomegalovirus retinitis (CMVR). An observational study of CMVR patients were performed. Complete ophthalmic examination, serial color fundus photography, structural OCT and OCTA were performed at baseline and follow-up visits for up to 12 months. The structural OCT was analyzed to evaluate macular areas within, bordering and beyond the CMVR lesions. Extralesional retinal capillary plexus of the macula were evaluated by OCT angiography and compared with the unaffected fellow eyes. Thirteen eyes from 13 patients were enrolled. At baseline, macular areas without CMVR lesions showed decreased vessel density (VD) of both the superficial (P = 0.0002) and deep (P < 0.0001) retinal capillary plexus in eyes with CMVR as compared with the corresponding macular areas of the unaffected fellow eyes. The decrease of VD persisted through the follow-up period for up to 12 months after adjusting for degree of vitreous haze. Structural macular OCT characteristics at the borders and beyond the lesions included intraretinal hyperreflective dots, cystoid macular edema, subretinal fluid and selective ellipsoid zone (EZ) loss. The selective EZ loss found in 6 of 12 eyes showed recovery in 4 eyes after receiving anti-viral treatment. In CMVR eyes, there were microvascular and microstructural abnormalities in the macular area without clinically visible CMVR lesions. Our results provided interesting insights into CMV infection of the retina.Nida WongchaisuwatSansanee KhongpipatchaisiriSutasinee BoonsoponPitipol ChoopongNattaporn TesavibulSupalert PrakhunhungsitSomanus ThoongsuwanNuttawut RodanantNopasak PhasukkijwatanaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nida Wongchaisuwat Sansanee Khongpipatchaisiri Sutasinee Boonsopon Pitipol Choopong Nattaporn Tesavibul Supalert Prakhunhungsit Somanus Thoongsuwan Nuttawut Rodanant Nopasak Phasukkijwatana Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis
description	Abstract To evaluate extralesional microvascular and structural changes of the macula using optical coherence tomography angiography (OCTA) and structural OCT in cytomegalovirus retinitis (CMVR). An observational study of CMVR patients were performed. Complete ophthalmic examination, serial color fundus photography, structural OCT and OCTA were performed at baseline and follow-up visits for up to 12 months. The structural OCT was analyzed to evaluate macular areas within, bordering and beyond the CMVR lesions. Extralesional retinal capillary plexus of the macula were evaluated by OCT angiography and compared with the unaffected fellow eyes. Thirteen eyes from 13 patients were enrolled. At baseline, macular areas without CMVR lesions showed decreased vessel density (VD) of both the superficial (P = 0.0002) and deep (P < 0.0001) retinal capillary plexus in eyes with CMVR as compared with the corresponding macular areas of the unaffected fellow eyes. The decrease of VD persisted through the follow-up period for up to 12 months after adjusting for degree of vitreous haze. Structural macular OCT characteristics at the borders and beyond the lesions included intraretinal hyperreflective dots, cystoid macular edema, subretinal fluid and selective ellipsoid zone (EZ) loss. The selective EZ loss found in 6 of 12 eyes showed recovery in 4 eyes after receiving anti-viral treatment. In CMVR eyes, there were microvascular and microstructural abnormalities in the macular area without clinically visible CMVR lesions. Our results provided interesting insights into CMV infection of the retina.
format	article
author	Nida Wongchaisuwat Sansanee Khongpipatchaisiri Sutasinee Boonsopon Pitipol Choopong Nattaporn Tesavibul Supalert Prakhunhungsit Somanus Thoongsuwan Nuttawut Rodanant Nopasak Phasukkijwatana
author_facet	Nida Wongchaisuwat Sansanee Khongpipatchaisiri Sutasinee Boonsopon Pitipol Choopong Nattaporn Tesavibul Supalert Prakhunhungsit Somanus Thoongsuwan Nuttawut Rodanant Nopasak Phasukkijwatana
author_sort	Nida Wongchaisuwat
title	Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis
title_short	Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis
title_full	Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis
title_fullStr	Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis
title_full_unstemmed	Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis
title_sort	extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c52e4330a059474db2410fd331ef1f98
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Extralesional microvascular and structural macular abnormalities in cytomegalovirus retinitis

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