Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing

Alternative splicing of influenza A virus (IAV) M transcript is regulated by hnRNP K and NS1-BP, but mechanistic details are unknown. Here, Thompson et al. show how hnRNP K and NS1-BP bind M mRNA and that these proteins regulate splicing of host transcripts in both the absence and presence of IAV in...

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Autores principales:	Matthew G. Thompson, Raquel Muñoz-Moreno, Prasanna Bhat, Renat Roytenberg, John Lindberg, Matthew R. Gazzara, Michael J. Mallory, Ke Zhang, Adolfo García-Sastre, Beatriz M. A. Fontoura, Kristen W. Lynch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c52fbc273a8e43cdb154def6db8f151a
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spelling	oai:doaj.org-article:c52fbc273a8e43cdb154def6db8f151a2021-12-02T17:32:14ZCo-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing10.1038/s41467-018-04779-42041-1723https://doaj.org/article/c52fbc273a8e43cdb154def6db8f151a2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04779-4https://doaj.org/toc/2041-1723Alternative splicing of influenza A virus (IAV) M transcript is regulated by hnRNP K and NS1-BP, but mechanistic details are unknown. Here, Thompson et al. show how hnRNP K and NS1-BP bind M mRNA and that these proteins regulate splicing of host transcripts in both the absence and presence of IAV infection.Matthew G. ThompsonRaquel Muñoz-MorenoPrasanna BhatRenat RoytenbergJohn LindbergMatthew R. GazzaraMichael J. MalloryKe ZhangAdolfo García-SastreBeatriz M. A. FontouraKristen W. LynchNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew G. Thompson Raquel Muñoz-Moreno Prasanna Bhat Renat Roytenberg John Lindberg Matthew R. Gazzara Michael J. Mallory Ke Zhang Adolfo García-Sastre Beatriz M. A. Fontoura Kristen W. Lynch Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing
description	Alternative splicing of influenza A virus (IAV) M transcript is regulated by hnRNP K and NS1-BP, but mechanistic details are unknown. Here, Thompson et al. show how hnRNP K and NS1-BP bind M mRNA and that these proteins regulate splicing of host transcripts in both the absence and presence of IAV infection.
format	article
author	Matthew G. Thompson Raquel Muñoz-Moreno Prasanna Bhat Renat Roytenberg John Lindberg Matthew R. Gazzara Michael J. Mallory Ke Zhang Adolfo García-Sastre Beatriz M. A. Fontoura Kristen W. Lynch
author_facet	Matthew G. Thompson Raquel Muñoz-Moreno Prasanna Bhat Renat Roytenberg John Lindberg Matthew R. Gazzara Michael J. Mallory Ke Zhang Adolfo García-Sastre Beatriz M. A. Fontoura Kristen W. Lynch
author_sort	Matthew G. Thompson
title	Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing
title_short	Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing
title_full	Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing
title_fullStr	Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing
title_full_unstemmed	Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing
title_sort	co-regulatory activity of hnrnp k and ns1-bp in influenza and human mrna splicing
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c52fbc273a8e43cdb154def6db8f151a
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Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing

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