Cellular Self-Digestion and Persistence in Bacteria

Cellular self-digestion is an evolutionarily conserved process occurring in prokaryotic cells that enables survival under stressful conditions by recycling essential energy molecules. Self-digestion, which is triggered by extracellular stress conditions, such as nutrient depletion and overpopulation...

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Autores principales:	Sayed Golam Mohiuddin, Sreyashi Ghosh, Han G. Ngo, Shayne Sensenbach, Prashant Karki, Narendra K. Dewangan, Vahideh Angardi, Mehmet A. Orman
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	self-digestion autophagy bacterial persisters intracellular degradation stationary-phase metabolism protein degradation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c53035fd1e474f00875d7f0adf6cd390
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spelling	oai:doaj.org-article:c53035fd1e474f00875d7f0adf6cd3902021-11-25T18:24:43ZCellular Self-Digestion and Persistence in Bacteria10.3390/microorganisms91122692076-2607https://doaj.org/article/c53035fd1e474f00875d7f0adf6cd3902021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2269https://doaj.org/toc/2076-2607Cellular self-digestion is an evolutionarily conserved process occurring in prokaryotic cells that enables survival under stressful conditions by recycling essential energy molecules. Self-digestion, which is triggered by extracellular stress conditions, such as nutrient depletion and overpopulation, induces degradation of intracellular components. This self-inflicted damage renders the bacterium less fit to produce building blocks and resume growth upon exposure to fresh nutrients. However, self-digestion may also provide temporary protection from antibiotics until the self-digestion-mediated damage is repaired. In fact, many persistence mechanisms identified to date may be directly or indirectly related to self-digestion, as these processes are also mediated by many degradative enzymes, including proteases and ribonucleases (RNases). In this review article, we will discuss the potential roles of self-digestion in bacterial persistence.Sayed Golam MohiuddinSreyashi GhoshHan G. NgoShayne SensenbachPrashant KarkiNarendra K. DewanganVahideh AngardiMehmet A. OrmanMDPI AGarticleself-digestionautophagybacterial persistersintracellular degradationstationary-phase metabolismprotein degradationBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2269, p 2269 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	self-digestion autophagy bacterial persisters intracellular degradation stationary-phase metabolism protein degradation Biology (General) QH301-705.5
spellingShingle	self-digestion autophagy bacterial persisters intracellular degradation stationary-phase metabolism protein degradation Biology (General) QH301-705.5 Sayed Golam Mohiuddin Sreyashi Ghosh Han G. Ngo Shayne Sensenbach Prashant Karki Narendra K. Dewangan Vahideh Angardi Mehmet A. Orman Cellular Self-Digestion and Persistence in Bacteria
description	Cellular self-digestion is an evolutionarily conserved process occurring in prokaryotic cells that enables survival under stressful conditions by recycling essential energy molecules. Self-digestion, which is triggered by extracellular stress conditions, such as nutrient depletion and overpopulation, induces degradation of intracellular components. This self-inflicted damage renders the bacterium less fit to produce building blocks and resume growth upon exposure to fresh nutrients. However, self-digestion may also provide temporary protection from antibiotics until the self-digestion-mediated damage is repaired. In fact, many persistence mechanisms identified to date may be directly or indirectly related to self-digestion, as these processes are also mediated by many degradative enzymes, including proteases and ribonucleases (RNases). In this review article, we will discuss the potential roles of self-digestion in bacterial persistence.
format	article
author	Sayed Golam Mohiuddin Sreyashi Ghosh Han G. Ngo Shayne Sensenbach Prashant Karki Narendra K. Dewangan Vahideh Angardi Mehmet A. Orman
author_facet	Sayed Golam Mohiuddin Sreyashi Ghosh Han G. Ngo Shayne Sensenbach Prashant Karki Narendra K. Dewangan Vahideh Angardi Mehmet A. Orman
author_sort	Sayed Golam Mohiuddin
title	Cellular Self-Digestion and Persistence in Bacteria
title_short	Cellular Self-Digestion and Persistence in Bacteria
title_full	Cellular Self-Digestion and Persistence in Bacteria
title_fullStr	Cellular Self-Digestion and Persistence in Bacteria
title_full_unstemmed	Cellular Self-Digestion and Persistence in Bacteria
title_sort	cellular self-digestion and persistence in bacteria
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c53035fd1e474f00875d7f0adf6cd390
work_keys_str_mv	AT sayedgolammohiuddin cellularselfdigestionandpersistenceinbacteria AT sreyashighosh cellularselfdigestionandpersistenceinbacteria AT hangngo cellularselfdigestionandpersistenceinbacteria AT shaynesensenbach cellularselfdigestionandpersistenceinbacteria AT prashantkarki cellularselfdigestionandpersistenceinbacteria AT narendrakdewangan cellularselfdigestionandpersistenceinbacteria AT vahidehangardi cellularselfdigestionandpersistenceinbacteria AT mehmetaorman cellularselfdigestionandpersistenceinbacteria
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Cellular Self-Digestion and Persistence in Bacteria

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