Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis.

<h4>Background</h4>A growing body of evidence has suggested that metformin potentially reduces the risk of cancer. Our objective was to enhance the precision of estimates of the effect of metformin on the risk of any-site and site-specific cancers in patients with diabetes.<h4>Meth...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hiroshi Noto, Atsushi Goto, Tetsuro Tsujimoto, Mitsuhiko Noda
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c532bfb50aec404995cd999c453b2ad3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c532bfb50aec404995cd999c453b2ad3
record_format	dspace
spelling	oai:doaj.org-article:c532bfb50aec404995cd999c453b2ad32021-11-18T07:24:42ZCancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis.1932-620310.1371/journal.pone.0033411https://doaj.org/article/c532bfb50aec404995cd999c453b2ad32012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22448244/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A growing body of evidence has suggested that metformin potentially reduces the risk of cancer. Our objective was to enhance the precision of estimates of the effect of metformin on the risk of any-site and site-specific cancers in patients with diabetes.<h4>Methods/principal findings</h4>We performed a search of MEDLINE, EMBASE, ISI Web of Science, Cochrane Library, and ClinicalTrials.gov for pertinent articles published as of October 12, 2011, and included them in a systematic review and meta-analysis. We calculated pooled risk ratios (RRs) for overall cancer mortality and cancer incidence. Of the 21,195 diabetic patients reported in 6 studies (4 cohort studies, 2 RCTs), 991 (4.5%) cases of death from cancer were reported. A total of 11,117 (5.3%) cases of incident cancer at any site were reported among 210,892 patients in 10 studies (2 RCTs, 6 cohort studies, 2 case-control studies). The risks of cancer among metformin users were significantly lower than those among non-metformin users: the pooled RRs (95% confidence interval) were 0.66 (0.49-0.88) for cancer mortality, 0.67 (0.53-0.85) for all-cancer incidence, 0.68 (0.53-0.88) for colorectal cancer (n = 6), 0.20 (0.07-0.59) for hepatocellular cancer (n = 4), 0.67 (0.45-0.99) for lung cancer (n = 3).<h4>Conclusion/significance</h4>The use of metformin in diabetic patients was associated with significantly lower risks of cancer mortality and incidence. However, this analysis is mainly based on observational studies and our findings underscore the more need for long-term RCTs to confirm this potential benefit for individuals with diabetes.Hiroshi NotoAtsushi GotoTetsuro TsujimotoMitsuhiko NodaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e33411 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiroshi Noto Atsushi Goto Tetsuro Tsujimoto Mitsuhiko Noda Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis.
description	<h4>Background</h4>A growing body of evidence has suggested that metformin potentially reduces the risk of cancer. Our objective was to enhance the precision of estimates of the effect of metformin on the risk of any-site and site-specific cancers in patients with diabetes.<h4>Methods/principal findings</h4>We performed a search of MEDLINE, EMBASE, ISI Web of Science, Cochrane Library, and ClinicalTrials.gov for pertinent articles published as of October 12, 2011, and included them in a systematic review and meta-analysis. We calculated pooled risk ratios (RRs) for overall cancer mortality and cancer incidence. Of the 21,195 diabetic patients reported in 6 studies (4 cohort studies, 2 RCTs), 991 (4.5%) cases of death from cancer were reported. A total of 11,117 (5.3%) cases of incident cancer at any site were reported among 210,892 patients in 10 studies (2 RCTs, 6 cohort studies, 2 case-control studies). The risks of cancer among metformin users were significantly lower than those among non-metformin users: the pooled RRs (95% confidence interval) were 0.66 (0.49-0.88) for cancer mortality, 0.67 (0.53-0.85) for all-cancer incidence, 0.68 (0.53-0.88) for colorectal cancer (n = 6), 0.20 (0.07-0.59) for hepatocellular cancer (n = 4), 0.67 (0.45-0.99) for lung cancer (n = 3).<h4>Conclusion/significance</h4>The use of metformin in diabetic patients was associated with significantly lower risks of cancer mortality and incidence. However, this analysis is mainly based on observational studies and our findings underscore the more need for long-term RCTs to confirm this potential benefit for individuals with diabetes.
format	article
author	Hiroshi Noto Atsushi Goto Tetsuro Tsujimoto Mitsuhiko Noda
author_facet	Hiroshi Noto Atsushi Goto Tetsuro Tsujimoto Mitsuhiko Noda
author_sort	Hiroshi Noto
title	Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis.
title_short	Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis.
title_full	Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis.
title_fullStr	Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis.
title_full_unstemmed	Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis.
title_sort	cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/c532bfb50aec404995cd999c453b2ad3
work_keys_str_mv	AT hiroshinoto cancerriskindiabeticpatientstreatedwithmetforminasystematicreviewandmetaanalysis AT atsushigoto cancerriskindiabeticpatientstreatedwithmetforminasystematicreviewandmetaanalysis AT tetsurotsujimoto cancerriskindiabeticpatientstreatedwithmetforminasystematicreviewandmetaanalysis AT mitsuhikonoda cancerriskindiabeticpatientstreatedwithmetforminasystematicreviewandmetaanalysis
_version_	1718423499203149824

Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis.

Ejemplares similares