An unexpected N-terminal loop in PD-1 dominates binding by nivolumab

Programmed cell death 1 (PD-1) is a key target for cancer immunotherapy. Here the authors present the crystal structure of the extracellular PD-1 domain with the clinically approved monoclonal antibody nivolumab, which shows that the N-terminal PD-1 loop is crucial for antibody binding.

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Autores principales:	Shuguang Tan, Hao Zhang, Yan Chai, Hao Song, Zhou Tong, Qihui Wang, Jianxun Qi, Gary Wong, Xiaodong Zhu, William J. Liu, Shan Gao, Zhongfu Wang, Yi Shi, Fuquan Yang, George F. Gao, Jinghua Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c5339e61324843929579ea934d9f1b79
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:c5339e61324843929579ea934d9f1b792021-12-02T17:06:15ZAn unexpected N-terminal loop in PD-1 dominates binding by nivolumab10.1038/ncomms143692041-1723https://doaj.org/article/c5339e61324843929579ea934d9f1b792017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14369https://doaj.org/toc/2041-1723Programmed cell death 1 (PD-1) is a key target for cancer immunotherapy. Here the authors present the crystal structure of the extracellular PD-1 domain with the clinically approved monoclonal antibody nivolumab, which shows that the N-terminal PD-1 loop is crucial for antibody binding.Shuguang TanHao ZhangYan ChaiHao SongZhou TongQihui WangJianxun QiGary WongXiaodong ZhuWilliam J. LiuShan GaoZhongfu WangYi ShiFuquan YangGeorge F. GaoJinghua YanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuguang Tan Hao Zhang Yan Chai Hao Song Zhou Tong Qihui Wang Jianxun Qi Gary Wong Xiaodong Zhu William J. Liu Shan Gao Zhongfu Wang Yi Shi Fuquan Yang George F. Gao Jinghua Yan An unexpected N-terminal loop in PD-1 dominates binding by nivolumab
description	Programmed cell death 1 (PD-1) is a key target for cancer immunotherapy. Here the authors present the crystal structure of the extracellular PD-1 domain with the clinically approved monoclonal antibody nivolumab, which shows that the N-terminal PD-1 loop is crucial for antibody binding.
format	article
author	Shuguang Tan Hao Zhang Yan Chai Hao Song Zhou Tong Qihui Wang Jianxun Qi Gary Wong Xiaodong Zhu William J. Liu Shan Gao Zhongfu Wang Yi Shi Fuquan Yang George F. Gao Jinghua Yan
author_facet	Shuguang Tan Hao Zhang Yan Chai Hao Song Zhou Tong Qihui Wang Jianxun Qi Gary Wong Xiaodong Zhu William J. Liu Shan Gao Zhongfu Wang Yi Shi Fuquan Yang George F. Gao Jinghua Yan
author_sort	Shuguang Tan
title	An unexpected N-terminal loop in PD-1 dominates binding by nivolumab
title_short	An unexpected N-terminal loop in PD-1 dominates binding by nivolumab
title_full	An unexpected N-terminal loop in PD-1 dominates binding by nivolumab
title_fullStr	An unexpected N-terminal loop in PD-1 dominates binding by nivolumab
title_full_unstemmed	An unexpected N-terminal loop in PD-1 dominates binding by nivolumab
title_sort	unexpected n-terminal loop in pd-1 dominates binding by nivolumab
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c5339e61324843929579ea934d9f1b79
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An unexpected N-terminal loop in PD-1 dominates binding by nivolumab

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