Prevalence of oropharyngeal dysphagia in geriatric patients and real-life associations with diseases and drugs

Abstract Risk factors for oropharyngeal dysphagia (OD) in elderly patients are mainly central nervous system (CNS) and structural organic diseases or presbyphagia. We analysed the OD prevalence and association of OD with multimorbidity and polypharmacy using real-life data to complete this spectrum,...

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Autores principales:	Ursula Wolf, Sandra Eckert, Grit Walter, Andreas Wienke, Sylva Bartel, Stefan K. Plontke, Christina Naumann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c53442fab8604bf2abaef5ca92a49853
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spelling	oai:doaj.org-article:c53442fab8604bf2abaef5ca92a498532021-11-14T12:19:23ZPrevalence of oropharyngeal dysphagia in geriatric patients and real-life associations with diseases and drugs10.1038/s41598-021-99858-w2045-2322https://doaj.org/article/c53442fab8604bf2abaef5ca92a498532021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99858-whttps://doaj.org/toc/2045-2322Abstract Risk factors for oropharyngeal dysphagia (OD) in elderly patients are mainly central nervous system (CNS) and structural organic diseases or presbyphagia. We analysed the OD prevalence and association of OD with multimorbidity and polypharmacy using real-life data to complete this spectrum, with a focus on further and iatrogenic risk. This was a cross-sectional retrospective study based on a random sample of 200 patients admitted to a geriatric hospital. Data analysis included diagnoses, the detailed list of drugs, and an intense clinical investigation of swallowing according to Stanschus to screen for OD in each patient. The mean patient age was 84 ± 6.5 years. The prevalence of OD was 29.0%, without an effect of age, but a higher rate was found in men and in nursing home residents and an elevated risk of pneumonia. OD risk was slight in diabetes mellitus and COPD, and pronounced in CNS diseases. A relevant OD association was found, even after adjusting for CNS diseases, with antipsychotics, benzodiazepines, anti-Parkinson drugs, antidepressants, and antiepileptics. Further risk of OD was found with beta-blockers, alpha-blockers, opioids, antiemetics, antivertiginosa or antihistamines, metoclopramide, domperidone, anticholinergics, loop diuretics, urologics, and ophthalmics. From real-life data in patients with and without CNS diseases, we identified drug groups associated with a risk of aggravating/inducing OD. Restrictive indications for these drugs may be a preventative contribution, requiring implementation in dysphagia guidelines and an integrative dysphagia risk scale that considers all associated and cumulative medication risks in addition to diseases.Ursula WolfSandra EckertGrit WalterAndreas WienkeSylva BartelStefan K. PlontkeChristina NaumannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ursula Wolf Sandra Eckert Grit Walter Andreas Wienke Sylva Bartel Stefan K. Plontke Christina Naumann Prevalence of oropharyngeal dysphagia in geriatric patients and real-life associations with diseases and drugs
description	Abstract Risk factors for oropharyngeal dysphagia (OD) in elderly patients are mainly central nervous system (CNS) and structural organic diseases or presbyphagia. We analysed the OD prevalence and association of OD with multimorbidity and polypharmacy using real-life data to complete this spectrum, with a focus on further and iatrogenic risk. This was a cross-sectional retrospective study based on a random sample of 200 patients admitted to a geriatric hospital. Data analysis included diagnoses, the detailed list of drugs, and an intense clinical investigation of swallowing according to Stanschus to screen for OD in each patient. The mean patient age was 84 ± 6.5 years. The prevalence of OD was 29.0%, without an effect of age, but a higher rate was found in men and in nursing home residents and an elevated risk of pneumonia. OD risk was slight in diabetes mellitus and COPD, and pronounced in CNS diseases. A relevant OD association was found, even after adjusting for CNS diseases, with antipsychotics, benzodiazepines, anti-Parkinson drugs, antidepressants, and antiepileptics. Further risk of OD was found with beta-blockers, alpha-blockers, opioids, antiemetics, antivertiginosa or antihistamines, metoclopramide, domperidone, anticholinergics, loop diuretics, urologics, and ophthalmics. From real-life data in patients with and without CNS diseases, we identified drug groups associated with a risk of aggravating/inducing OD. Restrictive indications for these drugs may be a preventative contribution, requiring implementation in dysphagia guidelines and an integrative dysphagia risk scale that considers all associated and cumulative medication risks in addition to diseases.
format	article
author	Ursula Wolf Sandra Eckert Grit Walter Andreas Wienke Sylva Bartel Stefan K. Plontke Christina Naumann
author_facet	Ursula Wolf Sandra Eckert Grit Walter Andreas Wienke Sylva Bartel Stefan K. Plontke Christina Naumann
author_sort	Ursula Wolf
title	Prevalence of oropharyngeal dysphagia in geriatric patients and real-life associations with diseases and drugs
title_short	Prevalence of oropharyngeal dysphagia in geriatric patients and real-life associations with diseases and drugs
title_full	Prevalence of oropharyngeal dysphagia in geriatric patients and real-life associations with diseases and drugs
title_fullStr	Prevalence of oropharyngeal dysphagia in geriatric patients and real-life associations with diseases and drugs
title_full_unstemmed	Prevalence of oropharyngeal dysphagia in geriatric patients and real-life associations with diseases and drugs
title_sort	prevalence of oropharyngeal dysphagia in geriatric patients and real-life associations with diseases and drugs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c53442fab8604bf2abaef5ca92a49853
work_keys_str_mv	AT ursulawolf prevalenceoforopharyngealdysphagiaingeriatricpatientsandreallifeassociationswithdiseasesanddrugs AT sandraeckert prevalenceoforopharyngealdysphagiaingeriatricpatientsandreallifeassociationswithdiseasesanddrugs AT gritwalter prevalenceoforopharyngealdysphagiaingeriatricpatientsandreallifeassociationswithdiseasesanddrugs AT andreaswienke prevalenceoforopharyngealdysphagiaingeriatricpatientsandreallifeassociationswithdiseasesanddrugs AT sylvabartel prevalenceoforopharyngealdysphagiaingeriatricpatientsandreallifeassociationswithdiseasesanddrugs AT stefankplontke prevalenceoforopharyngealdysphagiaingeriatricpatientsandreallifeassociationswithdiseasesanddrugs AT christinanaumann prevalenceoforopharyngealdysphagiaingeriatricpatientsandreallifeassociationswithdiseasesanddrugs
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Prevalence of oropharyngeal dysphagia in geriatric patients and real-life associations with diseases and drugs

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