Effects of Lingonberry (<i>Vaccinium vitis-idaea</i> L.) Supplementation on Hepatic Gene Expression in High-Fat Diet Fed Mice

The prevalence of nonalcoholic fatty liver disease (NAFLD) is growing worldwide in association with Western-style diet and increasing obesity. Lingonberry (<i>Vaccinium vitis-idaea</i> L.) is rich in polyphenols and has been shown to attenuate adverse metabolic changes in obese liver. Th...

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Autores principales:	Riitta Ryyti, Antti Pemmari, Rainer Peltola, Mari Hämäläinen, Eeva Moilanen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	lingonberry low-grade inflammation gene expression liver high-fat diet lipid metabolism Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/c536d5e0095340eead44ab7eb453cc30
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spelling	oai:doaj.org-article:c536d5e0095340eead44ab7eb453cc302021-11-25T18:33:14ZEffects of Lingonberry (<i>Vaccinium vitis-idaea</i> L.) Supplementation on Hepatic Gene Expression in High-Fat Diet Fed Mice10.3390/nu131136932072-6643https://doaj.org/article/c536d5e0095340eead44ab7eb453cc302021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3693https://doaj.org/toc/2072-6643The prevalence of nonalcoholic fatty liver disease (NAFLD) is growing worldwide in association with Western-style diet and increasing obesity. Lingonberry (<i>Vaccinium vitis-idaea</i> L.) is rich in polyphenols and has been shown to attenuate adverse metabolic changes in obese liver. This paper investigated the effects of lingonberry supplementation on hepatic gene expression in high-fat diet induced obesity in a mouse model. C57BL/6N male mice were fed for six weeks with either a high-fat (HF) or low-fat (LF) diet (46% and 10% energy from fat, respectively) or HF diet supplemented with air-dried lingonberry powder (HF + LGB). HF diet induced a major phenotypic change in the liver, predominantly affecting genes involved in inflammation and in glucose and lipid metabolism. Lingonberry supplementation prevented the effect of HF diet on an array of genes (in total on 263 genes) associated particularly with lipid or glucose metabolic process (such as <i>Mogat1</i>, <i>Plin4</i>, <i>Igfbp2</i>), inflammatory/immune response or cell migration (such as <i>Lcn2</i>, <i>Saa1</i>, <i>Saa2</i>, <i>Cxcl14</i>, <i>Gcp1</i>, <i>S100a10</i>) and cell cycle regulation (such as <i>Cdkn1a</i>, <i>Tubb2a</i>, <i>Tubb6</i>). The present results suggest that lingonberry supplementation prevents HF diet-induced adverse changes in the liver that are known to predispose the development of NAFLD and its comorbidities. The findings encourage carrying out human intervention trials to confirm the results, with the aim of recommending the use of lingonberries as a part of healthy diet against obesity and its hepatic and metabolic comorbidities.Riitta RyytiAntti PemmariRainer PeltolaMari HämäläinenEeva MoilanenMDPI AGarticlelingonberrylow-grade inflammationgene expressionliverhigh-fat dietlipid metabolismNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3693, p 3693 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lingonberry low-grade inflammation gene expression liver high-fat diet lipid metabolism Nutrition. Foods and food supply TX341-641
spellingShingle	lingonberry low-grade inflammation gene expression liver high-fat diet lipid metabolism Nutrition. Foods and food supply TX341-641 Riitta Ryyti Antti Pemmari Rainer Peltola Mari Hämäläinen Eeva Moilanen Effects of Lingonberry (<i>Vaccinium vitis-idaea</i> L.) Supplementation on Hepatic Gene Expression in High-Fat Diet Fed Mice
description	The prevalence of nonalcoholic fatty liver disease (NAFLD) is growing worldwide in association with Western-style diet and increasing obesity. Lingonberry (<i>Vaccinium vitis-idaea</i> L.) is rich in polyphenols and has been shown to attenuate adverse metabolic changes in obese liver. This paper investigated the effects of lingonberry supplementation on hepatic gene expression in high-fat diet induced obesity in a mouse model. C57BL/6N male mice were fed for six weeks with either a high-fat (HF) or low-fat (LF) diet (46% and 10% energy from fat, respectively) or HF diet supplemented with air-dried lingonberry powder (HF + LGB). HF diet induced a major phenotypic change in the liver, predominantly affecting genes involved in inflammation and in glucose and lipid metabolism. Lingonberry supplementation prevented the effect of HF diet on an array of genes (in total on 263 genes) associated particularly with lipid or glucose metabolic process (such as <i>Mogat1</i>, <i>Plin4</i>, <i>Igfbp2</i>), inflammatory/immune response or cell migration (such as <i>Lcn2</i>, <i>Saa1</i>, <i>Saa2</i>, <i>Cxcl14</i>, <i>Gcp1</i>, <i>S100a10</i>) and cell cycle regulation (such as <i>Cdkn1a</i>, <i>Tubb2a</i>, <i>Tubb6</i>). The present results suggest that lingonberry supplementation prevents HF diet-induced adverse changes in the liver that are known to predispose the development of NAFLD and its comorbidities. The findings encourage carrying out human intervention trials to confirm the results, with the aim of recommending the use of lingonberries as a part of healthy diet against obesity and its hepatic and metabolic comorbidities.
format	article
author	Riitta Ryyti Antti Pemmari Rainer Peltola Mari Hämäläinen Eeva Moilanen
author_facet	Riitta Ryyti Antti Pemmari Rainer Peltola Mari Hämäläinen Eeva Moilanen
author_sort	Riitta Ryyti
title	Effects of Lingonberry (<i>Vaccinium vitis-idaea</i> L.) Supplementation on Hepatic Gene Expression in High-Fat Diet Fed Mice
title_short	Effects of Lingonberry (<i>Vaccinium vitis-idaea</i> L.) Supplementation on Hepatic Gene Expression in High-Fat Diet Fed Mice
title_full	Effects of Lingonberry (<i>Vaccinium vitis-idaea</i> L.) Supplementation on Hepatic Gene Expression in High-Fat Diet Fed Mice
title_fullStr	Effects of Lingonberry (<i>Vaccinium vitis-idaea</i> L.) Supplementation on Hepatic Gene Expression in High-Fat Diet Fed Mice
title_full_unstemmed	Effects of Lingonberry (<i>Vaccinium vitis-idaea</i> L.) Supplementation on Hepatic Gene Expression in High-Fat Diet Fed Mice
title_sort	effects of lingonberry (<i>vaccinium vitis-idaea</i> l.) supplementation on hepatic gene expression in high-fat diet fed mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c536d5e0095340eead44ab7eb453cc30
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Effects of Lingonberry (<i>Vaccinium vitis-idaea</i> L.) Supplementation on Hepatic Gene Expression in High-Fat Diet Fed Mice

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