The value of quantitative diffusion tensor imaging indices of spinal cord disorders

Abstract Background Different lesions affecting the spinal cord can lead to myelopathy. Diffusion tensor imaging (DTI) is widely used to predict the degree of spinal cord microstructure affection and to assess axonal integrity and diffusion directionality. We hypothesized that not all DTI parameters...

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Autores principales:	Mohammad Koriem Mahmoud Omar, Abd El-Karem Hasan Abd Allah, Mona Gouda Maghrabi, Mohamed Zidan Mohamed
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	MRI Diffusion tensor imaging FA ADC VR RA Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/c539bc6f351648be90d97855afaa8713
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spelling	oai:doaj.org-article:c539bc6f351648be90d97855afaa87132021-11-14T12:27:09ZThe value of quantitative diffusion tensor imaging indices of spinal cord disorders10.1186/s43055-021-00596-w2090-4762https://doaj.org/article/c539bc6f351648be90d97855afaa87132021-11-01T00:00:00Zhttps://doi.org/10.1186/s43055-021-00596-whttps://doaj.org/toc/2090-4762Abstract Background Different lesions affecting the spinal cord can lead to myelopathy. Diffusion tensor imaging (DTI) is widely used to predict the degree of spinal cord microstructure affection and to assess axonal integrity and diffusion directionality. We hypothesized that not all DTI parameters have the same affection with different spinal cord pathologies. The purpose of this study is to assess the value of the quantitative diffusion tensor imaging indices in different spinal cord lesions. Results There is highly statistically significant difference of the fractional anisotropy (FA), relative anisotropy (RA), volume ratio (VR) and secondary eigenvector values (E2 and E3) between various studied cord lesions and control levels. There is no statistically significant difference of the apparent diffusion coefficient (ADC) and the primary eigenvector value (E1) (ANOVA test). The ROC curve analysis showed the higher sensitivity and accuracy were ‘88% and 62.5%, respectively,’ with FA cutoff value about 0.380. Conclusion The resulted quantitative DTI indices ‘fractional anisotropy, relative anisotropy, volume ratio and secondary eigenvalues’ work as a numerical in vivo marker of overall tissue injury in different pathologies affecting the spinal cord.Mohammad Koriem Mahmoud OmarAbd El-Karem Hasan Abd AllahMona Gouda MaghrabiMohamed Zidan MohamedSpringerOpenarticleMRIDiffusion tensor imagingFAADCVRRAMedical physics. Medical radiology. Nuclear medicineR895-920ENThe Egyptian Journal of Radiology and Nuclear Medicine, Vol 52, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MRI Diffusion tensor imaging FA ADC VR RA Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	MRI Diffusion tensor imaging FA ADC VR RA Medical physics. Medical radiology. Nuclear medicine R895-920 Mohammad Koriem Mahmoud Omar Abd El-Karem Hasan Abd Allah Mona Gouda Maghrabi Mohamed Zidan Mohamed The value of quantitative diffusion tensor imaging indices of spinal cord disorders
description	Abstract Background Different lesions affecting the spinal cord can lead to myelopathy. Diffusion tensor imaging (DTI) is widely used to predict the degree of spinal cord microstructure affection and to assess axonal integrity and diffusion directionality. We hypothesized that not all DTI parameters have the same affection with different spinal cord pathologies. The purpose of this study is to assess the value of the quantitative diffusion tensor imaging indices in different spinal cord lesions. Results There is highly statistically significant difference of the fractional anisotropy (FA), relative anisotropy (RA), volume ratio (VR) and secondary eigenvector values (E2 and E3) between various studied cord lesions and control levels. There is no statistically significant difference of the apparent diffusion coefficient (ADC) and the primary eigenvector value (E1) (ANOVA test). The ROC curve analysis showed the higher sensitivity and accuracy were ‘88% and 62.5%, respectively,’ with FA cutoff value about 0.380. Conclusion The resulted quantitative DTI indices ‘fractional anisotropy, relative anisotropy, volume ratio and secondary eigenvalues’ work as a numerical in vivo marker of overall tissue injury in different pathologies affecting the spinal cord.
format	article
author	Mohammad Koriem Mahmoud Omar Abd El-Karem Hasan Abd Allah Mona Gouda Maghrabi Mohamed Zidan Mohamed
author_facet	Mohammad Koriem Mahmoud Omar Abd El-Karem Hasan Abd Allah Mona Gouda Maghrabi Mohamed Zidan Mohamed
author_sort	Mohammad Koriem Mahmoud Omar
title	The value of quantitative diffusion tensor imaging indices of spinal cord disorders
title_short	The value of quantitative diffusion tensor imaging indices of spinal cord disorders
title_full	The value of quantitative diffusion tensor imaging indices of spinal cord disorders
title_fullStr	The value of quantitative diffusion tensor imaging indices of spinal cord disorders
title_full_unstemmed	The value of quantitative diffusion tensor imaging indices of spinal cord disorders
title_sort	value of quantitative diffusion tensor imaging indices of spinal cord disorders
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/c539bc6f351648be90d97855afaa8713
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The value of quantitative diffusion tensor imaging indices of spinal cord disorders

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