Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms

J Carlos Villa Guzmán,1 J Espinosa,1 R Cervera,1 M Delgado,2 R Patón,3 JM Cordero García41Department of Medical Oncology, 2Department of Pathology, 3Department of Gastroenterology, 4Department of Nuclear Medicine, University Ciudad Real General Hospital, Ciudad Real,...

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Autores principales:	Villa Guzmán JC, Espinosa J, Cervera R, Delgado M, Patón R, Cordero García JM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Lobular breast cancer gastrointestinal metastases and chemokines Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/c53f76a987744862bd40643926242e1f
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spelling	oai:doaj.org-article:c53f76a987744862bd40643926242e1f2021-12-02T06:54:24ZGastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms1179-1314https://doaj.org/article/c53f76a987744862bd40643926242e1f2016-12-01T00:00:00Zhttps://www.dovepress.com/gastric-and-colon-metastasis-from-breast-cancer-case-report-review-of--peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314J Carlos Villa Guzmán,1 J Espinosa,1 R Cervera,1 M Delgado,2 R Patón,3 JM Cordero García41Department of Medical Oncology, 2Department of Pathology, 3Department of Gastroenterology, 4Department of Nuclear Medicine, University Ciudad Real General Hospital, Ciudad Real, Spain Abstract: Gastrointestinal metastases from breast cancer are not common. We present a 58-year-old female diagnosed with lobular breast cancer some years before whose relapses were gastric and colonic mucosal. Simultaneous metastases are extremely rare. To our knowledge, no cases of initial dual affectation have been reported. The patient also showed gastritis by Helicobacter pylori. Invasive lobular breast carcinoma is the most frequent special type of breast cancer and carries some specific molecular alterations such as loss of expression of E-cadherin. Although underlying mechanisms of metastasization are not entirely known, chemokines as well as inflammatory events seem to be implicated in this process. Interaction between chemokines and their receptors frequently induces cell migration. We hypothesize that H. pylori, inflammatory cells, and chemokines may create a favorable environment attracting tumor cells. Keywords: chemokines, gastrointestinal metastases, H. pylori, lobular carcinomaVilla Guzmán JCEspinosa JCervera RDelgado MPatón RCordero García JMDove Medical PressarticleLobular breast cancergastrointestinal metastases and chemokinesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 9, Pp 1-7 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lobular breast cancer gastrointestinal metastases and chemokines Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Lobular breast cancer gastrointestinal metastases and chemokines Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Villa Guzmán JC Espinosa J Cervera R Delgado M Patón R Cordero García JM Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms
description	J Carlos Villa Guzmán,1 J Espinosa,1 R Cervera,1 M Delgado,2 R Patón,3 JM Cordero García41Department of Medical Oncology, 2Department of Pathology, 3Department of Gastroenterology, 4Department of Nuclear Medicine, University Ciudad Real General Hospital, Ciudad Real, Spain Abstract: Gastrointestinal metastases from breast cancer are not common. We present a 58-year-old female diagnosed with lobular breast cancer some years before whose relapses were gastric and colonic mucosal. Simultaneous metastases are extremely rare. To our knowledge, no cases of initial dual affectation have been reported. The patient also showed gastritis by Helicobacter pylori. Invasive lobular breast carcinoma is the most frequent special type of breast cancer and carries some specific molecular alterations such as loss of expression of E-cadherin. Although underlying mechanisms of metastasization are not entirely known, chemokines as well as inflammatory events seem to be implicated in this process. Interaction between chemokines and their receptors frequently induces cell migration. We hypothesize that H. pylori, inflammatory cells, and chemokines may create a favorable environment attracting tumor cells. Keywords: chemokines, gastrointestinal metastases, H. pylori, lobular carcinoma
format	article
author	Villa Guzmán JC Espinosa J Cervera R Delgado M Patón R Cordero García JM
author_facet	Villa Guzmán JC Espinosa J Cervera R Delgado M Patón R Cordero García JM
author_sort	Villa Guzmán JC
title	Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms
title_short	Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms
title_full	Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms
title_fullStr	Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms
title_full_unstemmed	Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms
title_sort	gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/c53f76a987744862bd40643926242e1f
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Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms

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