Is hypertriglyceridemia a prognostic factor in sepsis?

Ali Cetinkaya,1 Abdulsamet Erden,1 Deniz Avci,1 Hatice Karagoz,1 Samet Karahan,1 Mustafa Basak,1 Kadir Bulut,1 Vedat Gencer,1 Hasan Mutlu2 1Internal Medicine Department, Kayseri Training and Research Hospital, Kayseri, Turkey; 2Medical Oncology Department, Acibadem Kayseri Hospital, Kayseri, Turkey...

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Autores principales:	Cetinkaya A, Erden A, Avci D, Karagoz H, Karahan S, Basak M, Bulut K, Gencer V, Mutlu H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c540db91cdfd4b76a29592ecc07af7fb
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spelling	oai:doaj.org-article:c540db91cdfd4b76a29592ecc07af7fb2021-12-02T11:21:05ZIs hypertriglyceridemia a prognostic factor in sepsis?1178-203Xhttps://doaj.org/article/c540db91cdfd4b76a29592ecc07af7fb2014-02-01T00:00:00Zhttp://www.dovepress.com/is-hypertriglyceridemia-a-prognostic-factor-in-sepsis-a15980https://doaj.org/toc/1178-203X Ali Cetinkaya,1 Abdulsamet Erden,1 Deniz Avci,1 Hatice Karagoz,1 Samet Karahan,1 Mustafa Basak,1 Kadir Bulut,1 Vedat Gencer,1 Hasan Mutlu2 1Internal Medicine Department, Kayseri Training and Research Hospital, Kayseri, Turkey; 2Medical Oncology Department, Acibadem Kayseri Hospital, Kayseri, Turkey Introduction: Sepsis and septic shock are important causes of mortality in intensive care unit patients, hence early diagnosis and therapy are important in management of their treatment. The available information on sepsis patients is not enough to recommend or to discard the routine evaluation of triglyceride (TG) levels at the onset of sepsis. The aim of this study was to investigate the association of hypertriglyceridemia and clinical outcome (or mortality) in patients with severe sepsis. Materials and methods: Between January 1 and December 31, 2011, a total of 84 patients with sepsis from the intensive internal care unit at the Kayseri Training and Research Hospital, Kayseri, Turkey, were investigated retrospectively. Sepsis was defined according to the American College of Chest Physicians/Society of Critical Care Medicine/European Society of Intensive Care Medicine consensus conference definitions. For each patient, survival was recorded at the end of the last day of hospitalization as dead or alive. The TG values were taken retrospectively from the records, which were performed routinely for each patient with sepsis at the time of diagnosis. TG >150 mg/dL was considered as hypertriglyceridemia. Results: The percentages of male and female patients were 44% and 56%, respectively. The mean age of patients was 71.49±11.071 years. The percentage of patients with TG values more than 150 mg/dL was 81% (25/31) in the non-survivor group and 19% (6/31) in the survivor group. There was a significant difference regarding TG values between groups (P=0.039). Discussion: It was observed in this study that patients in the intensive care unit with sepsis had high TG levels. We also observed that the TG level >150 mg/dL at 0 hour (onset of sepsis) was a significant predictive marker of sepsis mortality rate. The contribution of hypertriglyceridemia to mortality might be modest compared to increase in severity of illness, but, nevertheless, these simple measurements represent a potential therapeutic target in sepsis. Keywords: triglyceride, prognosis, mortality, sepsisCetinkaya AErden AAvci DKaragoz HKarahan SBasak MBulut KGencer VMutlu HDove Medical PressarticleTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol 2014, Iss default, Pp 147-150 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950
spellingShingle	Therapeutics. Pharmacology RM1-950 Cetinkaya A Erden A Avci D Karagoz H Karahan S Basak M Bulut K Gencer V Mutlu H Is hypertriglyceridemia a prognostic factor in sepsis?
description	Ali Cetinkaya,1 Abdulsamet Erden,1 Deniz Avci,1 Hatice Karagoz,1 Samet Karahan,1 Mustafa Basak,1 Kadir Bulut,1 Vedat Gencer,1 Hasan Mutlu2 1Internal Medicine Department, Kayseri Training and Research Hospital, Kayseri, Turkey; 2Medical Oncology Department, Acibadem Kayseri Hospital, Kayseri, Turkey Introduction: Sepsis and septic shock are important causes of mortality in intensive care unit patients, hence early diagnosis and therapy are important in management of their treatment. The available information on sepsis patients is not enough to recommend or to discard the routine evaluation of triglyceride (TG) levels at the onset of sepsis. The aim of this study was to investigate the association of hypertriglyceridemia and clinical outcome (or mortality) in patients with severe sepsis. Materials and methods: Between January 1 and December 31, 2011, a total of 84 patients with sepsis from the intensive internal care unit at the Kayseri Training and Research Hospital, Kayseri, Turkey, were investigated retrospectively. Sepsis was defined according to the American College of Chest Physicians/Society of Critical Care Medicine/European Society of Intensive Care Medicine consensus conference definitions. For each patient, survival was recorded at the end of the last day of hospitalization as dead or alive. The TG values were taken retrospectively from the records, which were performed routinely for each patient with sepsis at the time of diagnosis. TG >150 mg/dL was considered as hypertriglyceridemia. Results: The percentages of male and female patients were 44% and 56%, respectively. The mean age of patients was 71.49±11.071 years. The percentage of patients with TG values more than 150 mg/dL was 81% (25/31) in the non-survivor group and 19% (6/31) in the survivor group. There was a significant difference regarding TG values between groups (P=0.039). Discussion: It was observed in this study that patients in the intensive care unit with sepsis had high TG levels. We also observed that the TG level >150 mg/dL at 0 hour (onset of sepsis) was a significant predictive marker of sepsis mortality rate. The contribution of hypertriglyceridemia to mortality might be modest compared to increase in severity of illness, but, nevertheless, these simple measurements represent a potential therapeutic target in sepsis. Keywords: triglyceride, prognosis, mortality, sepsis
format	article
author	Cetinkaya A Erden A Avci D Karagoz H Karahan S Basak M Bulut K Gencer V Mutlu H
author_facet	Cetinkaya A Erden A Avci D Karagoz H Karahan S Basak M Bulut K Gencer V Mutlu H
author_sort	Cetinkaya A
title	Is hypertriglyceridemia a prognostic factor in sepsis?
title_short	Is hypertriglyceridemia a prognostic factor in sepsis?
title_full	Is hypertriglyceridemia a prognostic factor in sepsis?
title_fullStr	Is hypertriglyceridemia a prognostic factor in sepsis?
title_full_unstemmed	Is hypertriglyceridemia a prognostic factor in sepsis?
title_sort	is hypertriglyceridemia a prognostic factor in sepsis?
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/c540db91cdfd4b76a29592ecc07af7fb
work_keys_str_mv	AT cetinkayaa ishypertriglyceridemiaaprognosticfactorinsepsis AT erdena ishypertriglyceridemiaaprognosticfactorinsepsis AT avcid ishypertriglyceridemiaaprognosticfactorinsepsis AT karagozh ishypertriglyceridemiaaprognosticfactorinsepsis AT karahans ishypertriglyceridemiaaprognosticfactorinsepsis AT basakm ishypertriglyceridemiaaprognosticfactorinsepsis AT bulutk ishypertriglyceridemiaaprognosticfactorinsepsis AT gencerv ishypertriglyceridemiaaprognosticfactorinsepsis AT mutluh ishypertriglyceridemiaaprognosticfactorinsepsis
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Is hypertriglyceridemia a prognostic factor in sepsis?

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