A Retrospective Study of Clinical and Histopathological Features of 81 Cases of Canine Apocrine Gland Adenocarcinoma of the Anal Sac: Independent Clinical and Histopathological Risk Factors Associated with Outcome

Canine apocrine gland anal sac adenocarcinoma (AGASAC) is a malignant tumour with variable clinical progression. The objective of this study was to use robust multivariate models, based on models employed in human medical oncology, to establish clinical and histopathological risk factors of poor sur...

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Autores principales:	Hannah Wong, Stephanie Byrne, Roberta Rasotto, Randi Drees, Angela Taylor, Simon L. Priestnall, Chiara Leo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	anal sac adenocarcinoma apocrine gland histology hypercalcemia necrosis prognosis Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/c540f2d985974b2b994b9639fc33c20c
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spelling	oai:doaj.org-article:c540f2d985974b2b994b9639fc33c20c2021-11-25T16:21:36ZA Retrospective Study of Clinical and Histopathological Features of 81 Cases of Canine Apocrine Gland Adenocarcinoma of the Anal Sac: Independent Clinical and Histopathological Risk Factors Associated with Outcome10.3390/ani111133272076-2615https://doaj.org/article/c540f2d985974b2b994b9639fc33c20c2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3327https://doaj.org/toc/2076-2615Canine apocrine gland anal sac adenocarcinoma (AGASAC) is a malignant tumour with variable clinical progression. The objective of this study was to use robust multivariate models, based on models employed in human medical oncology, to establish clinical and histopathological risk factors of poor survival. Clinical data and imaging of 81 cases with AGASAC were reviewed. Tissue was available for histological review and immunohistochemistry in 49 cases. Tumour and lymph node size were determined using the response evaluation criteria in the solid tumours system (RECIST). Modelling revealed tumour size over 2 cm, lymph node size grouped in three tiers by the two thresholds 1.6 cm and 5 cm, surgical management, and radiotherapy were independent clinical variables associated with survival, irrespective of tumour stage. Tumour size over 1.3 cm and presence of distant metastasis were independent clinical variables associated with the first progression-free interval. The presence of the histopathological variables of tumour necrosis, a solid histological pattern, and vascular invasion in the primary tumour were independent risk factors of poor survival. Based upon these independent risk factors, scoring algorithms to predict survival in AGASAC patients are presented.Hannah WongStephanie ByrneRoberta RasottoRandi DreesAngela TaylorSimon L. PriestnallChiara LeoMDPI AGarticleanal sac adenocarcinomaapocrine glandhistologyhypercalcemianecrosisprognosisVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3327, p 3327 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anal sac adenocarcinoma apocrine gland histology hypercalcemia necrosis prognosis Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	anal sac adenocarcinoma apocrine gland histology hypercalcemia necrosis prognosis Veterinary medicine SF600-1100 Zoology QL1-991 Hannah Wong Stephanie Byrne Roberta Rasotto Randi Drees Angela Taylor Simon L. Priestnall Chiara Leo A Retrospective Study of Clinical and Histopathological Features of 81 Cases of Canine Apocrine Gland Adenocarcinoma of the Anal Sac: Independent Clinical and Histopathological Risk Factors Associated with Outcome
description	Canine apocrine gland anal sac adenocarcinoma (AGASAC) is a malignant tumour with variable clinical progression. The objective of this study was to use robust multivariate models, based on models employed in human medical oncology, to establish clinical and histopathological risk factors of poor survival. Clinical data and imaging of 81 cases with AGASAC were reviewed. Tissue was available for histological review and immunohistochemistry in 49 cases. Tumour and lymph node size were determined using the response evaluation criteria in the solid tumours system (RECIST). Modelling revealed tumour size over 2 cm, lymph node size grouped in three tiers by the two thresholds 1.6 cm and 5 cm, surgical management, and radiotherapy were independent clinical variables associated with survival, irrespective of tumour stage. Tumour size over 1.3 cm and presence of distant metastasis were independent clinical variables associated with the first progression-free interval. The presence of the histopathological variables of tumour necrosis, a solid histological pattern, and vascular invasion in the primary tumour were independent risk factors of poor survival. Based upon these independent risk factors, scoring algorithms to predict survival in AGASAC patients are presented.
format	article
author	Hannah Wong Stephanie Byrne Roberta Rasotto Randi Drees Angela Taylor Simon L. Priestnall Chiara Leo
author_facet	Hannah Wong Stephanie Byrne Roberta Rasotto Randi Drees Angela Taylor Simon L. Priestnall Chiara Leo
author_sort	Hannah Wong
title	A Retrospective Study of Clinical and Histopathological Features of 81 Cases of Canine Apocrine Gland Adenocarcinoma of the Anal Sac: Independent Clinical and Histopathological Risk Factors Associated with Outcome
title_short	A Retrospective Study of Clinical and Histopathological Features of 81 Cases of Canine Apocrine Gland Adenocarcinoma of the Anal Sac: Independent Clinical and Histopathological Risk Factors Associated with Outcome
title_full	A Retrospective Study of Clinical and Histopathological Features of 81 Cases of Canine Apocrine Gland Adenocarcinoma of the Anal Sac: Independent Clinical and Histopathological Risk Factors Associated with Outcome
title_fullStr	A Retrospective Study of Clinical and Histopathological Features of 81 Cases of Canine Apocrine Gland Adenocarcinoma of the Anal Sac: Independent Clinical and Histopathological Risk Factors Associated with Outcome
title_full_unstemmed	A Retrospective Study of Clinical and Histopathological Features of 81 Cases of Canine Apocrine Gland Adenocarcinoma of the Anal Sac: Independent Clinical and Histopathological Risk Factors Associated with Outcome
title_sort	retrospective study of clinical and histopathological features of 81 cases of canine apocrine gland adenocarcinoma of the anal sac: independent clinical and histopathological risk factors associated with outcome
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c540f2d985974b2b994b9639fc33c20c
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A Retrospective Study of Clinical and Histopathological Features of 81 Cases of Canine Apocrine Gland Adenocarcinoma of the Anal Sac: Independent Clinical and Histopathological Risk Factors Associated with Outcome

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