Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors

Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. Here, authors describe four crystal structures of CysLT2R in complex with three dual CysLT1R/CysLT2R antagonists, which shed light on CysLTR ligand selectivity.

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Autores principales:	Anastasiia Gusach, Aleksandra Luginina, Egor Marin, Rebecca L. Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Andrii Ishchenko, Petr Popov, Nilkanth Patel, Taku Fujimoto, Toru Maruyama, Benjamin Stauch, Margarita Ergasheva, Daria Romanovskaia, Anastasiia Stepko, Kirill Kovalev, Mikhail Shevtsov, Valentin Gordeliy, Gye Won Han, Vsevolod Katritch, Valentin Borshchevskiy, Philippe Sarret, Alexey Mishin, Vadim Cherezov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c54160b2896f4e3f9bcd8053dc21a8c7
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spelling	oai:doaj.org-article:c54160b2896f4e3f9bcd8053dc21a8c72021-12-02T14:39:38ZStructural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors10.1038/s41467-019-13348-22041-1723https://doaj.org/article/c54160b2896f4e3f9bcd8053dc21a8c72019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13348-2https://doaj.org/toc/2041-1723Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. Here, authors describe four crystal structures of CysLT2R in complex with three dual CysLT1R/CysLT2R antagonists, which shed light on CysLTR ligand selectivity.Anastasiia GusachAleksandra LugininaEgor MarinRebecca L. BrouilletteÉlie Besserer-OffroyJean-Michel LongpréAndrii IshchenkoPetr PopovNilkanth PatelTaku FujimotoToru MaruyamaBenjamin StauchMargarita ErgashevaDaria RomanovskaiaAnastasiia StepkoKirill KovalevMikhail ShevtsovValentin GordeliyGye Won HanVsevolod KatritchValentin BorshchevskiyPhilippe SarretAlexey MishinVadim CherezovNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anastasiia Gusach Aleksandra Luginina Egor Marin Rebecca L. Brouillette Élie Besserer-Offroy Jean-Michel Longpré Andrii Ishchenko Petr Popov Nilkanth Patel Taku Fujimoto Toru Maruyama Benjamin Stauch Margarita Ergasheva Daria Romanovskaia Anastasiia Stepko Kirill Kovalev Mikhail Shevtsov Valentin Gordeliy Gye Won Han Vsevolod Katritch Valentin Borshchevskiy Philippe Sarret Alexey Mishin Vadim Cherezov Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
description	Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. Here, authors describe four crystal structures of CysLT2R in complex with three dual CysLT1R/CysLT2R antagonists, which shed light on CysLTR ligand selectivity.
format	article
author	Anastasiia Gusach Aleksandra Luginina Egor Marin Rebecca L. Brouillette Élie Besserer-Offroy Jean-Michel Longpré Andrii Ishchenko Petr Popov Nilkanth Patel Taku Fujimoto Toru Maruyama Benjamin Stauch Margarita Ergasheva Daria Romanovskaia Anastasiia Stepko Kirill Kovalev Mikhail Shevtsov Valentin Gordeliy Gye Won Han Vsevolod Katritch Valentin Borshchevskiy Philippe Sarret Alexey Mishin Vadim Cherezov
author_facet	Anastasiia Gusach Aleksandra Luginina Egor Marin Rebecca L. Brouillette Élie Besserer-Offroy Jean-Michel Longpré Andrii Ishchenko Petr Popov Nilkanth Patel Taku Fujimoto Toru Maruyama Benjamin Stauch Margarita Ergasheva Daria Romanovskaia Anastasiia Stepko Kirill Kovalev Mikhail Shevtsov Valentin Gordeliy Gye Won Han Vsevolod Katritch Valentin Borshchevskiy Philippe Sarret Alexey Mishin Vadim Cherezov
author_sort	Anastasiia Gusach
title	Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
title_short	Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
title_full	Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
title_fullStr	Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
title_full_unstemmed	Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
title_sort	structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c54160b2896f4e3f9bcd8053dc21a8c7
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Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors

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