FMRP regulates STAT3 mRNA localization to cellular protrusions and local translation to promote hepatocellular carcinoma metastasis

Shen et al. propose a mechanism for the metastasis of hepatocellular carcinoma (HCC) cells through the localization and translation modulation of the STAT3 oncogene by fragile X mental retardation protein (FMRP). To this end, the authors also find that FMRP knockdown efficiently suppresses HCC metas...

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Autores principales:	Zhifa Shen, Bowen Liu, Biting Wu, Hongyin Zhou, Xiangyun Wang, Jinling Cao, Min Jiang, Yingying Zhou, Feixia Guo, Chang Xue, Zai-Sheng Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c5469822c028494c8fabd249667c6c12
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spelling	oai:doaj.org-article:c5469822c028494c8fabd249667c6c122021-12-02T15:36:12ZFMRP regulates STAT3 mRNA localization to cellular protrusions and local translation to promote hepatocellular carcinoma metastasis10.1038/s42003-021-02071-82399-3642https://doaj.org/article/c5469822c028494c8fabd249667c6c122021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02071-8https://doaj.org/toc/2399-3642Shen et al. propose a mechanism for the metastasis of hepatocellular carcinoma (HCC) cells through the localization and translation modulation of the STAT3 oncogene by fragile X mental retardation protein (FMRP). To this end, the authors also find that FMRP knockdown efficiently suppresses HCC metastasis in vitro and in vivo.Zhifa ShenBowen LiuBiting WuHongyin ZhouXiangyun WangJinling CaoMin JiangYingying ZhouFeixia GuoChang XueZai-Sheng WuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Zhifa Shen Bowen Liu Biting Wu Hongyin Zhou Xiangyun Wang Jinling Cao Min Jiang Yingying Zhou Feixia Guo Chang Xue Zai-Sheng Wu FMRP regulates STAT3 mRNA localization to cellular protrusions and local translation to promote hepatocellular carcinoma metastasis
description	Shen et al. propose a mechanism for the metastasis of hepatocellular carcinoma (HCC) cells through the localization and translation modulation of the STAT3 oncogene by fragile X mental retardation protein (FMRP). To this end, the authors also find that FMRP knockdown efficiently suppresses HCC metastasis in vitro and in vivo.
format	article
author	Zhifa Shen Bowen Liu Biting Wu Hongyin Zhou Xiangyun Wang Jinling Cao Min Jiang Yingying Zhou Feixia Guo Chang Xue Zai-Sheng Wu
author_facet	Zhifa Shen Bowen Liu Biting Wu Hongyin Zhou Xiangyun Wang Jinling Cao Min Jiang Yingying Zhou Feixia Guo Chang Xue Zai-Sheng Wu
author_sort	Zhifa Shen
title	FMRP regulates STAT3 mRNA localization to cellular protrusions and local translation to promote hepatocellular carcinoma metastasis
title_short	FMRP regulates STAT3 mRNA localization to cellular protrusions and local translation to promote hepatocellular carcinoma metastasis
title_full	FMRP regulates STAT3 mRNA localization to cellular protrusions and local translation to promote hepatocellular carcinoma metastasis
title_fullStr	FMRP regulates STAT3 mRNA localization to cellular protrusions and local translation to promote hepatocellular carcinoma metastasis
title_full_unstemmed	FMRP regulates STAT3 mRNA localization to cellular protrusions and local translation to promote hepatocellular carcinoma metastasis
title_sort	fmrp regulates stat3 mrna localization to cellular protrusions and local translation to promote hepatocellular carcinoma metastasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c5469822c028494c8fabd249667c6c12
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FMRP regulates STAT3 mRNA localization to cellular protrusions and local translation to promote hepatocellular carcinoma metastasis

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