Catalytic Functionalized Structured Monolithic Micro-/Mesoreactors: Engineering, Properties, and Performance in Flow Synthesis: An Overview and Guidelines

In this review article, we first discussed the development of silica monoliths with hierarchical macro-/mesopore structure and their potential figures of merit as continuous-flow micro-/mesoreactors of up to 30 ml working volume. Making use of the flow hindrance of different pore structures seen fro...

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Autores principales:	Katarzyna Szymańska, Agnieszka Ciemięga, Katarzyna Maresz, Wojciech Pudło, Janusz Malinowski, Julita Mrowiec-Białoń, Andrzej B. Jarzębski
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	in-flow synthesis structured monolithic reactors micro-/mesoreactors enzymatic microreactors process intensification Technology T Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/c5480a7568f14fa3acbdbdf4db8816c0
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spelling	oai:doaj.org-article:c5480a7568f14fa3acbdbdf4db8816c02021-12-02T11:02:50ZCatalytic Functionalized Structured Monolithic Micro-/Mesoreactors: Engineering, Properties, and Performance in Flow Synthesis: An Overview and Guidelines2673-271810.3389/fceng.2021.789102https://doaj.org/article/c5480a7568f14fa3acbdbdf4db8816c02021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fceng.2021.789102/fullhttps://doaj.org/toc/2673-2718In this review article, we first discussed the development of silica monoliths with hierarchical macro-/mesopore structure and their potential figures of merit as continuous-flow micro-/mesoreactors of up to 30 ml working volume. Making use of the flow hindrance of different pore structures seen from the Darcy law perspective, we discriminated four structures of the monoliths (M1–M4). We then summarized the most important results, mainly from our studies of continuous-flow structured monolithic reactors and rotating bed reactors (RBRs) filled with structured pellets, activated with various catalytic entities and enzymes. The results show that an increase in the flow rate and thus velocity in reactors activated with more conventional catalytic sites has no or a minor positive effect on the apparent reaction rate. On the contrary, in those with the most open structure (M1) and functionalized with enzymes, it could increase by more than two orders of magnitude even at low overpressures. The production systems worked stably for at least 200 h. To conclude, the synthetic system made of the hierarchically structured monoliths, or RBRs filled with structured catalytic pellets, lay the foundation for a new platform for the high-yield production of a wide variety of specialty chemicals, even on a multikilogram scale, in a safe and sustained manner.Katarzyna SzymańskaAgnieszka CiemięgaKatarzyna MareszWojciech PudłoJanusz MalinowskiJulita Mrowiec-BiałońJulita Mrowiec-BiałońAndrzej B. JarzębskiFrontiers Media S.A.articlein-flow synthesisstructured monolithic reactorsmicro-/mesoreactorsenzymatic microreactorsprocess intensificationTechnologyTChemical technologyTP1-1185ENFrontiers in Chemical Engineering, Vol 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	in-flow synthesis structured monolithic reactors micro-/mesoreactors enzymatic microreactors process intensification Technology T Chemical technology TP1-1185
spellingShingle	in-flow synthesis structured monolithic reactors micro-/mesoreactors enzymatic microreactors process intensification Technology T Chemical technology TP1-1185 Katarzyna Szymańska Agnieszka Ciemięga Katarzyna Maresz Wojciech Pudło Janusz Malinowski Julita Mrowiec-Białoń Julita Mrowiec-Białoń Andrzej B. Jarzębski Catalytic Functionalized Structured Monolithic Micro-/Mesoreactors: Engineering, Properties, and Performance in Flow Synthesis: An Overview and Guidelines
description	In this review article, we first discussed the development of silica monoliths with hierarchical macro-/mesopore structure and their potential figures of merit as continuous-flow micro-/mesoreactors of up to 30 ml working volume. Making use of the flow hindrance of different pore structures seen from the Darcy law perspective, we discriminated four structures of the monoliths (M1–M4). We then summarized the most important results, mainly from our studies of continuous-flow structured monolithic reactors and rotating bed reactors (RBRs) filled with structured pellets, activated with various catalytic entities and enzymes. The results show that an increase in the flow rate and thus velocity in reactors activated with more conventional catalytic sites has no or a minor positive effect on the apparent reaction rate. On the contrary, in those with the most open structure (M1) and functionalized with enzymes, it could increase by more than two orders of magnitude even at low overpressures. The production systems worked stably for at least 200 h. To conclude, the synthetic system made of the hierarchically structured monoliths, or RBRs filled with structured catalytic pellets, lay the foundation for a new platform for the high-yield production of a wide variety of specialty chemicals, even on a multikilogram scale, in a safe and sustained manner.
format	article
author	Katarzyna Szymańska Agnieszka Ciemięga Katarzyna Maresz Wojciech Pudło Janusz Malinowski Julita Mrowiec-Białoń Julita Mrowiec-Białoń Andrzej B. Jarzębski
author_facet	Katarzyna Szymańska Agnieszka Ciemięga Katarzyna Maresz Wojciech Pudło Janusz Malinowski Julita Mrowiec-Białoń Julita Mrowiec-Białoń Andrzej B. Jarzębski
author_sort	Katarzyna Szymańska
title	Catalytic Functionalized Structured Monolithic Micro-/Mesoreactors: Engineering, Properties, and Performance in Flow Synthesis: An Overview and Guidelines
title_short	Catalytic Functionalized Structured Monolithic Micro-/Mesoreactors: Engineering, Properties, and Performance in Flow Synthesis: An Overview and Guidelines
title_full	Catalytic Functionalized Structured Monolithic Micro-/Mesoreactors: Engineering, Properties, and Performance in Flow Synthesis: An Overview and Guidelines
title_fullStr	Catalytic Functionalized Structured Monolithic Micro-/Mesoreactors: Engineering, Properties, and Performance in Flow Synthesis: An Overview and Guidelines
title_full_unstemmed	Catalytic Functionalized Structured Monolithic Micro-/Mesoreactors: Engineering, Properties, and Performance in Flow Synthesis: An Overview and Guidelines
title_sort	catalytic functionalized structured monolithic micro-/mesoreactors: engineering, properties, and performance in flow synthesis: an overview and guidelines
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c5480a7568f14fa3acbdbdf4db8816c0
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Catalytic Functionalized Structured Monolithic Micro-/Mesoreactors: Engineering, Properties, and Performance in Flow Synthesis: An Overview and Guidelines

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