α-amylase and α-glucosidase antidiabetic potential of ten essential oils from Calophyllum inophyllum Linn

Introduction: Diabetes mellitus (DM) is a multifactorial metabolic disorder which is of public health concern. Therapeutic intervention using reliable, affordable and non-toxic natural sources is crucial. Aim of the study: This research was designed to evaluate the α-amylase and α-glucosidase inhib...

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Autores principales:	Emmanuel Onah Ojah, Dorcas Olufunke Moronkola, Adeniyi-Akee Mukaram Akintunde
Formato:	article
Lenguaje:	EN
Publicado:	Emergency Department of Hospital San Pedro (Logroño, Spain) 2020
Materias:	diabetes mellitus hyperglycemia medicinal plants calophyllum inophyllum α-amylase inhibition α-glucosidase inhibition Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c5487d2fd0034abca28500a93adf7f5e
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spelling	oai:doaj.org-article:c5487d2fd0034abca28500a93adf7f5e2021-12-02T19:15:07Zα-amylase and α-glucosidase antidiabetic potential of ten essential oils from Calophyllum inophyllum Linn10.5281/zenodo.38411082695-5075https://doaj.org/article/c5487d2fd0034abca28500a93adf7f5e2020-05-01T00:00:00Zhttps://doi.org/10.5281/zenodo.3841108https://doaj.org/toc/2695-5075Introduction: Diabetes mellitus (DM) is a multifactorial metabolic disorder which is of public health concern. Therapeutic intervention using reliable, affordable and non-toxic natural sources is crucial. Aim of the study: This research was designed to evaluate the α-amylase and α-glucosidase inhibitory activities of ten essential oils from Calophyllum inophyllum Linn. The study is part of our local sourcing for natural promising leads to ameliorating diabetes mellitus globally. Materials and methods: Essential oils from ten parts of C. inophyllum Linn were extracted by hydro-distillation using all-glass Clevenger-type apparatus. The percentage yields (w/v) were between 0.219 and 0.506 %. A plot of percentage inhibition versus concentration (mg/mL) of essential oils gave the IC50 values for each essential oil using non-linear regression analysis in reference to acarbose a standard anti-diabetic drug. Results: The following IC50 values (mg/mL) were obtained in the determination of α-amylase inhibition: [(Leaf, 0.043±0.05); (Leaf-stalk, 0.044±0.02); (Flower, 0.045±0.05); (Seed, 0.042±0.03); (Pod, 0.040±0.05); (Peel, 0.047±0.09); (Stem wood, 0.047±0.02); (Stem bark, 0.049±0.05); (Root wood, 0.048±0.05) and (Root bark, 0.046±0.04)] compared to acarbose (0.034±0.02). While α-glucosidase assay gave the following IC50 values (mg/mL): [(Leaf, 0.044±0.02); (Leaf-stalk, 0.043±0.03); (Flower, 0.044±0.04); (Seed, 0.048±0.02); (Pod, 0.038±0.04); (Peel, 0.048±0.03); (Stem wood, 0.048±0.04); (Stem bark, 0.048±0.02); (Root wood, 0.047±0.04) and (Root bark, 0.045±0.04)] with reference to acarbose (0.032±0.04). The high α-amylase and α-glucosidase inhibitory activity of pod essential oil in comparison with the reference drug must be due to the presence of some impact bioactive phyto-contituents in it. Conclusion: C. inophyllum Linn has been considered a fundamental source of potent anti-diabetic drugs which could be useful in the management of postprandial hyperglycemia.Emmanuel Onah OjahDorcas Olufunke MoronkolaAdeniyi-Akee Mukaram AkintundeEmergency Department of Hospital San Pedro (Logroño, Spain)articlediabetes mellitushyperglycemiamedicinal plantscalophyllum inophyllumα-amylase inhibitionα-glucosidase inhibitionMedicine (General)R5-920ENIberoamerican Journal of Medicine, Vol 2, Iss 4, Pp 253-260 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus hyperglycemia medicinal plants calophyllum inophyllum α-amylase inhibition α-glucosidase inhibition Medicine (General) R5-920
spellingShingle	diabetes mellitus hyperglycemia medicinal plants calophyllum inophyllum α-amylase inhibition α-glucosidase inhibition Medicine (General) R5-920 Emmanuel Onah Ojah Dorcas Olufunke Moronkola Adeniyi-Akee Mukaram Akintunde α-amylase and α-glucosidase antidiabetic potential of ten essential oils from Calophyllum inophyllum Linn
description	Introduction: Diabetes mellitus (DM) is a multifactorial metabolic disorder which is of public health concern. Therapeutic intervention using reliable, affordable and non-toxic natural sources is crucial. Aim of the study: This research was designed to evaluate the α-amylase and α-glucosidase inhibitory activities of ten essential oils from Calophyllum inophyllum Linn. The study is part of our local sourcing for natural promising leads to ameliorating diabetes mellitus globally. Materials and methods: Essential oils from ten parts of C. inophyllum Linn were extracted by hydro-distillation using all-glass Clevenger-type apparatus. The percentage yields (w/v) were between 0.219 and 0.506 %. A plot of percentage inhibition versus concentration (mg/mL) of essential oils gave the IC50 values for each essential oil using non-linear regression analysis in reference to acarbose a standard anti-diabetic drug. Results: The following IC50 values (mg/mL) were obtained in the determination of α-amylase inhibition: [(Leaf, 0.043±0.05); (Leaf-stalk, 0.044±0.02); (Flower, 0.045±0.05); (Seed, 0.042±0.03); (Pod, 0.040±0.05); (Peel, 0.047±0.09); (Stem wood, 0.047±0.02); (Stem bark, 0.049±0.05); (Root wood, 0.048±0.05) and (Root bark, 0.046±0.04)] compared to acarbose (0.034±0.02). While α-glucosidase assay gave the following IC50 values (mg/mL): [(Leaf, 0.044±0.02); (Leaf-stalk, 0.043±0.03); (Flower, 0.044±0.04); (Seed, 0.048±0.02); (Pod, 0.038±0.04); (Peel, 0.048±0.03); (Stem wood, 0.048±0.04); (Stem bark, 0.048±0.02); (Root wood, 0.047±0.04) and (Root bark, 0.045±0.04)] with reference to acarbose (0.032±0.04). The high α-amylase and α-glucosidase inhibitory activity of pod essential oil in comparison with the reference drug must be due to the presence of some impact bioactive phyto-contituents in it. Conclusion: C. inophyllum Linn has been considered a fundamental source of potent anti-diabetic drugs which could be useful in the management of postprandial hyperglycemia.
format	article
author	Emmanuel Onah Ojah Dorcas Olufunke Moronkola Adeniyi-Akee Mukaram Akintunde
author_facet	Emmanuel Onah Ojah Dorcas Olufunke Moronkola Adeniyi-Akee Mukaram Akintunde
author_sort	Emmanuel Onah Ojah
title	α-amylase and α-glucosidase antidiabetic potential of ten essential oils from Calophyllum inophyllum Linn
title_short	α-amylase and α-glucosidase antidiabetic potential of ten essential oils from Calophyllum inophyllum Linn
title_full	α-amylase and α-glucosidase antidiabetic potential of ten essential oils from Calophyllum inophyllum Linn
title_fullStr	α-amylase and α-glucosidase antidiabetic potential of ten essential oils from Calophyllum inophyllum Linn
title_full_unstemmed	α-amylase and α-glucosidase antidiabetic potential of ten essential oils from Calophyllum inophyllum Linn
title_sort	α-amylase and α-glucosidase antidiabetic potential of ten essential oils from calophyllum inophyllum linn
publisher	Emergency Department of Hospital San Pedro (Logroño, Spain)
publishDate	2020
url	https://doaj.org/article/c5487d2fd0034abca28500a93adf7f5e
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α-amylase and α-glucosidase antidiabetic potential of ten essential oils from Calophyllum inophyllum Linn

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