Effects of dietary Astragalus membranaceus (Fisch.) Bge. root extract on growth performance, plasma biochemical parameters, fish composition, liver and intestinal morphology, and genes expression in head kidney of hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀)

In recent years, plant extracts have been paid more and more attention as immune enhancers for aquatic animals instead of antibiotics. In the present study, the effects of Astragalus membranaceus extract on growth performance, body composition, plasma biochemistry analysis, intestinal and liver hist...

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Autores principales:	Zhenzhu Sun, Zonglu Wei, Qingying Liu, Haobin Mai, Yang Liu, Bo Liu, Xiaohong Tan, Chaoxia Ye
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Astragalus extract Hybrid grouper Serum biochemical parameters Histomorphology Aquaculture. Fisheries. Angling SH1-691
Acceso en línea:	https://doaj.org/article/c5501b227fb74b8b890992a3348b8bdd
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spelling	oai:doaj.org-article:c5501b227fb74b8b890992a3348b8bdd2021-11-10T04:28:44ZEffects of dietary Astragalus membranaceus (Fisch.) Bge. root extract on growth performance, plasma biochemical parameters, fish composition, liver and intestinal morphology, and genes expression in head kidney of hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀)2352-513410.1016/j.aqrep.2021.100934https://doaj.org/article/c5501b227fb74b8b890992a3348b8bdd2022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352513421003513https://doaj.org/toc/2352-5134In recent years, plant extracts have been paid more and more attention as immune enhancers for aquatic animals instead of antibiotics. In the present study, the effects of Astragalus membranaceus extract on growth performance, body composition, plasma biochemistry analysis, intestinal and liver histology and gene expression were investigated in hybrid groupers (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀). Five groups of experimental diets were prepared by adding different levels (0%, 0.1%, 0.2%, 0.4%, and 0.8%) of Astragalus extract in the basal diet. Samples were collected at the end of the 8-week feeding experiment. The results showed that Astragalus extract (AE) had no significant effect on the weight gain rate and feed efficiency ratio of hybrid grouper (P > 0.05). There were no significant difference of the contents of crude protein, crude lipids, moisture and ash in the whole body and muscle of hybrid groupers (P > 0.05). The villous structure of the foregut and midgut, the hepatocyte size and the integrity of cell membrane in each experimental group has no significant changes too. The changes of villus length in the hindgut becomes longer as the increases of AE addition. The addition of 0.1% and 0.2% of AE significantly reduced serum cholesterol content (P < 0.05). The relative mRNA expressions of Caspase 9, Keap1 and IL-8 in head kidney of fish showed a significant increase trend with the addition of AE (P < 0.05). The results showed that dietary AE could not significantly improve the growth performance and liver morphology even though could improve hindgut morphology of hybrid grouper.Zhenzhu SunZonglu WeiQingying LiuHaobin MaiYang LiuBo LiuXiaohong TanChaoxia YeElsevierarticleAstragalus extractHybrid grouperSerum biochemical parametersHistomorphologyAquaculture. Fisheries. AnglingSH1-691ENAquaculture Reports, Vol 22, Iss , Pp 100934- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Astragalus extract Hybrid grouper Serum biochemical parameters Histomorphology Aquaculture. Fisheries. Angling SH1-691
spellingShingle	Astragalus extract Hybrid grouper Serum biochemical parameters Histomorphology Aquaculture. Fisheries. Angling SH1-691 Zhenzhu Sun Zonglu Wei Qingying Liu Haobin Mai Yang Liu Bo Liu Xiaohong Tan Chaoxia Ye Effects of dietary Astragalus membranaceus (Fisch.) Bge. root extract on growth performance, plasma biochemical parameters, fish composition, liver and intestinal morphology, and genes expression in head kidney of hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀)
description	In recent years, plant extracts have been paid more and more attention as immune enhancers for aquatic animals instead of antibiotics. In the present study, the effects of Astragalus membranaceus extract on growth performance, body composition, plasma biochemistry analysis, intestinal and liver histology and gene expression were investigated in hybrid groupers (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀). Five groups of experimental diets were prepared by adding different levels (0%, 0.1%, 0.2%, 0.4%, and 0.8%) of Astragalus extract in the basal diet. Samples were collected at the end of the 8-week feeding experiment. The results showed that Astragalus extract (AE) had no significant effect on the weight gain rate and feed efficiency ratio of hybrid grouper (P > 0.05). There were no significant difference of the contents of crude protein, crude lipids, moisture and ash in the whole body and muscle of hybrid groupers (P > 0.05). The villous structure of the foregut and midgut, the hepatocyte size and the integrity of cell membrane in each experimental group has no significant changes too. The changes of villus length in the hindgut becomes longer as the increases of AE addition. The addition of 0.1% and 0.2% of AE significantly reduced serum cholesterol content (P < 0.05). The relative mRNA expressions of Caspase 9, Keap1 and IL-8 in head kidney of fish showed a significant increase trend with the addition of AE (P < 0.05). The results showed that dietary AE could not significantly improve the growth performance and liver morphology even though could improve hindgut morphology of hybrid grouper.
format	article
author	Zhenzhu Sun Zonglu Wei Qingying Liu Haobin Mai Yang Liu Bo Liu Xiaohong Tan Chaoxia Ye
author_facet	Zhenzhu Sun Zonglu Wei Qingying Liu Haobin Mai Yang Liu Bo Liu Xiaohong Tan Chaoxia Ye
author_sort	Zhenzhu Sun
title	Effects of dietary Astragalus membranaceus (Fisch.) Bge. root extract on growth performance, plasma biochemical parameters, fish composition, liver and intestinal morphology, and genes expression in head kidney of hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀)
title_short	Effects of dietary Astragalus membranaceus (Fisch.) Bge. root extract on growth performance, plasma biochemical parameters, fish composition, liver and intestinal morphology, and genes expression in head kidney of hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀)
title_full	Effects of dietary Astragalus membranaceus (Fisch.) Bge. root extract on growth performance, plasma biochemical parameters, fish composition, liver and intestinal morphology, and genes expression in head kidney of hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀)
title_fullStr	Effects of dietary Astragalus membranaceus (Fisch.) Bge. root extract on growth performance, plasma biochemical parameters, fish composition, liver and intestinal morphology, and genes expression in head kidney of hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀)
title_full_unstemmed	Effects of dietary Astragalus membranaceus (Fisch.) Bge. root extract on growth performance, plasma biochemical parameters, fish composition, liver and intestinal morphology, and genes expression in head kidney of hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀)
title_sort	effects of dietary astragalus membranaceus (fisch.) bge. root extract on growth performance, plasma biochemical parameters, fish composition, liver and intestinal morphology, and genes expression in head kidney of hybrid grouper (epinephelus lanceolatus♂ × epinephelus fuscoguttatus♀)
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/c5501b227fb74b8b890992a3348b8bdd
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Effects of dietary Astragalus membranaceus (Fisch.) Bge. root extract on growth performance, plasma biochemical parameters, fish composition, liver and intestinal morphology, and genes expression in head kidney of hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀)

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