A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer
Here, the authors present the structure of the HIV envelope (Env) protein from a transmitted founder virus and show that, while the overall structure of the Env trimer is similar to other closed trimers, the fusion peptide is buried in the hydrophobic core of the trimer, which is similar to open sta...
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| Lenguaje: | EN |
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Nature Portfolio
2019
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| Acceso en línea: | https://doaj.org/article/c550b5e3e0bf452baf0fa1bf3de54854 |
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oai:doaj.org-article:c550b5e3e0bf452baf0fa1bf3de548542021-12-02T16:57:23ZA sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer10.1038/s41467-019-08825-72041-1723https://doaj.org/article/c550b5e3e0bf452baf0fa1bf3de548542019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08825-7https://doaj.org/toc/2041-1723Here, the authors present the structure of the HIV envelope (Env) protein from a transmitted founder virus and show that, while the overall structure of the Env trimer is similar to other closed trimers, the fusion peptide is buried in the hydrophobic core of the trimer, which is similar to open state trimers.Neeti AnanthaswamyQianglin FangWadad AlSalmiSwati JainZhenguo ChenThomas KloseYingyuan SunYue LiuMarthandan MahalingamSubhash ChandSodsai TovanabutraMerlin L. RobbMichael G. RossmannVenigalla B. RaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Neeti Ananthaswamy Qianglin Fang Wadad AlSalmi Swati Jain Zhenguo Chen Thomas Klose Yingyuan Sun Yue Liu Marthandan Mahalingam Subhash Chand Sodsai Tovanabutra Merlin L. Robb Michael G. Rossmann Venigalla B. Rao A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer |
| description |
Here, the authors present the structure of the HIV envelope (Env) protein from a transmitted founder virus and show that, while the overall structure of the Env trimer is similar to other closed trimers, the fusion peptide is buried in the hydrophobic core of the trimer, which is similar to open state trimers. |
| format |
article |
| author |
Neeti Ananthaswamy Qianglin Fang Wadad AlSalmi Swati Jain Zhenguo Chen Thomas Klose Yingyuan Sun Yue Liu Marthandan Mahalingam Subhash Chand Sodsai Tovanabutra Merlin L. Robb Michael G. Rossmann Venigalla B. Rao |
| author_facet |
Neeti Ananthaswamy Qianglin Fang Wadad AlSalmi Swati Jain Zhenguo Chen Thomas Klose Yingyuan Sun Yue Liu Marthandan Mahalingam Subhash Chand Sodsai Tovanabutra Merlin L. Robb Michael G. Rossmann Venigalla B. Rao |
| author_sort |
Neeti Ananthaswamy |
| title |
A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer |
| title_short |
A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer |
| title_full |
A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer |
| title_fullStr |
A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer |
| title_full_unstemmed |
A sequestered fusion peptide in the structure of an HIV-1 transmitted founder envelope trimer |
| title_sort |
sequestered fusion peptide in the structure of an hiv-1 transmitted founder envelope trimer |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/c550b5e3e0bf452baf0fa1bf3de54854 |
| work_keys_str_mv |
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| _version_ |
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