A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells

Single CD34 negative haematopoietic stem cells (HSCs) can fully reconstitute lympho-myeloid hematopoiesis in mice. Here, using single cell transplantation and gene expression analyses, the authors show that CD34 negative HSCs lie at the apex of haematopoiesis in human cord blood and that they can gi...

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Autores principales:	Keisuke Sumide, Yoshikazu Matsuoka, Hiroshi Kawamura, Ryusuke Nakatsuka, Tatsuya Fujioka, Hiroaki Asano, Yoshihiro Takihara, Yoshiaki Sonoda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c550f20a25a54ac691d698a7862e3926
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spelling	oai:doaj.org-article:c550f20a25a54ac691d698a7862e39262021-12-02T16:56:56ZA revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells10.1038/s41467-018-04441-z2041-1723https://doaj.org/article/c550f20a25a54ac691d698a7862e39262018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04441-zhttps://doaj.org/toc/2041-1723Single CD34 negative haematopoietic stem cells (HSCs) can fully reconstitute lympho-myeloid hematopoiesis in mice. Here, using single cell transplantation and gene expression analyses, the authors show that CD34 negative HSCs lie at the apex of haematopoiesis in human cord blood and that they can give rise to erythroid megakaryocytic progenitors.Keisuke SumideYoshikazu MatsuokaHiroshi KawamuraRyusuke NakatsukaTatsuya FujiokaHiroaki AsanoYoshihiro TakiharaYoshiaki SonodaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Keisuke Sumide Yoshikazu Matsuoka Hiroshi Kawamura Ryusuke Nakatsuka Tatsuya Fujioka Hiroaki Asano Yoshihiro Takihara Yoshiaki Sonoda A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells
description	Single CD34 negative haematopoietic stem cells (HSCs) can fully reconstitute lympho-myeloid hematopoiesis in mice. Here, using single cell transplantation and gene expression analyses, the authors show that CD34 negative HSCs lie at the apex of haematopoiesis in human cord blood and that they can give rise to erythroid megakaryocytic progenitors.
format	article
author	Keisuke Sumide Yoshikazu Matsuoka Hiroshi Kawamura Ryusuke Nakatsuka Tatsuya Fujioka Hiroaki Asano Yoshihiro Takihara Yoshiaki Sonoda
author_facet	Keisuke Sumide Yoshikazu Matsuoka Hiroshi Kawamura Ryusuke Nakatsuka Tatsuya Fujioka Hiroaki Asano Yoshihiro Takihara Yoshiaki Sonoda
author_sort	Keisuke Sumide
title	A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells
title_short	A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells
title_full	A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells
title_fullStr	A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells
title_full_unstemmed	A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells
title_sort	revised road map for the commitment of human cord blood cd34-negative hematopoietic stem cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c550f20a25a54ac691d698a7862e3926
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A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells

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