Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation

Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation

The order of DNA methylation and histone modifications during transcription remained unclear. Here the authors show that HMGA2 induces DNA nicks at TGFB1-responsive genes, promoting nucleosome incorporation containing γ-H2AX, which is required for repair-mediated DNA demethylation and transcription....

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Autores principales: Stephanie Dobersch, Karla Rubio, Indrabahadur Singh, Stefan Günther, Johannes Graumann, Julio Cordero, Rafael Castillo-Negrete, Minh Bao Huynh, Aditi Mehta, Peter Braubach, Hector Cabrera-Fuentes, Jürgen Bernhagen, Cho-Ming Chao, Saverio Bellusci, Andreas Günther, Klaus T. Preissner, Sita Kugel, Gergana Dobreva, Malgorzata Wygrecka, Thomas Braun, Dulce Papy-Garcia, Guillermo Barreto
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c551a764a6c040d58f3cbdc0affd583b
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spelling oai:doaj.org-article:c551a764a6c040d58f3cbdc0affd583b2021-12-02T14:03:50ZPositioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation10.1038/s41467-021-21227-y2041-1723https://doaj.org/article/c551a764a6c040d58f3cbdc0affd583b2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21227-yhttps://doaj.org/toc/2041-1723The order of DNA methylation and histone modifications during transcription remained unclear. Here the authors show that HMGA2 induces DNA nicks at TGFB1-responsive genes, promoting nucleosome incorporation containing γ-H2AX, which is required for repair-mediated DNA demethylation and transcription.Stephanie DoberschKarla RubioIndrabahadur SinghStefan GüntherJohannes GraumannJulio CorderoRafael Castillo-NegreteMinh Bao HuynhAditi MehtaPeter BraubachHector Cabrera-FuentesJürgen BernhagenCho-Ming ChaoSaverio BellusciAndreas GüntherKlaus T. PreissnerSita KugelGergana DobrevaMalgorzata WygreckaThomas BraunDulce Papy-GarciaGuillermo BarretoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Stephanie Dobersch
Karla Rubio
Indrabahadur Singh
Stefan Günther
Johannes Graumann
Julio Cordero
Rafael Castillo-Negrete
Minh Bao Huynh
Aditi Mehta
Peter Braubach
Hector Cabrera-Fuentes
Jürgen Bernhagen
Cho-Ming Chao
Saverio Bellusci
Andreas Günther
Klaus T. Preissner
Sita Kugel
Gergana Dobreva
Malgorzata Wygrecka
Thomas Braun
Dulce Papy-Garcia
Guillermo Barreto
Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation
description The order of DNA methylation and histone modifications during transcription remained unclear. Here the authors show that HMGA2 induces DNA nicks at TGFB1-responsive genes, promoting nucleosome incorporation containing γ-H2AX, which is required for repair-mediated DNA demethylation and transcription.
format article
author Stephanie Dobersch
Karla Rubio
Indrabahadur Singh
Stefan Günther
Johannes Graumann
Julio Cordero
Rafael Castillo-Negrete
Minh Bao Huynh
Aditi Mehta
Peter Braubach
Hector Cabrera-Fuentes
Jürgen Bernhagen
Cho-Ming Chao
Saverio Bellusci
Andreas Günther
Klaus T. Preissner
Sita Kugel
Gergana Dobreva
Malgorzata Wygrecka
Thomas Braun
Dulce Papy-Garcia
Guillermo Barreto
author_facet Stephanie Dobersch
Karla Rubio
Indrabahadur Singh
Stefan Günther
Johannes Graumann
Julio Cordero
Rafael Castillo-Negrete
Minh Bao Huynh
Aditi Mehta
Peter Braubach
Hector Cabrera-Fuentes
Jürgen Bernhagen
Cho-Ming Chao
Saverio Bellusci
Andreas Günther
Klaus T. Preissner
Sita Kugel
Gergana Dobreva
Malgorzata Wygrecka
Thomas Braun
Dulce Papy-Garcia
Guillermo Barreto
author_sort Stephanie Dobersch
title Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation
title_short Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation
title_full Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation
title_fullStr Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation
title_full_unstemmed Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation
title_sort positioning of nucleosomes containing γ-h2ax precedes active dna demethylation and transcription initiation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c551a764a6c040d58f3cbdc0affd583b
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