Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor

Abstract This study aimed to investigate the nutricosmetic effect of Asparagus officinalis extracts. The tip and spear of A. officinalis were successively extracted with 95% ethanol. The rutin, phenolic, and flavonoid contents of A. officinalis extracts were investigated. The antioxidant activities...

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Autores principales:	Suwannee Sriyab, Nachtharinee Laosirisathian, Chanun Punyoyai, Songyot Anuchapreeda, Singkome Tima, Sawitree Chiampanichayakul, Wantida Chaiyana
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c55211e2a64946ec9b35c700f8cded78
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spelling	oai:doaj.org-article:c55211e2a64946ec9b35c700f8cded782021-12-02T13:44:15ZNutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor10.1038/s41598-021-88340-22045-2322https://doaj.org/article/c55211e2a64946ec9b35c700f8cded782021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88340-2https://doaj.org/toc/2045-2322Abstract This study aimed to investigate the nutricosmetic effect of Asparagus officinalis extracts. The tip and spear of A. officinalis were successively extracted with 95% ethanol. The rutin, phenolic, and flavonoid contents of A. officinalis extracts were investigated. The antioxidant activities were determined by 2,2-azinobis (3-ethylbenzothiazoline-6-sulphonic acid) and a ferric reducing antioxidant power assay. Matrix metalloproteinase-1 (MMP-1), elastase, and hyaluronidase inhibition were determined by in vitro enzyme reaction assay. The cytotoxicity was analyzed on peripheral blood mononuclear cellss. Findings revealed that drying temperature and drying duration had significant effects on the chemical composition and biological activity of A. officinalis extract. A. officinalis tips dried at 50 °C for 24 h contained the (significantly) highest flavonoid and rutin content. The most potent extract was from A. officinalis spears since it possessed the (significantly) highest MMP-1, elastase, and hyaluronidase inhibition rates of 83.4 ± 1.5%, 70.4 ± 4.1%, and 75.2 ± 1.0%, respectively. Interestingly, at the same concentration, the A. officinalis spear extract was more potent in MMP-1 inhibition than oleanolic acid and epigallocatechin gallate, the well-known natural MMP-1 inhibitors. The results show that A. officinalis extract is an attractive source of natural anti-skin-wrinkle ingredients.Suwannee SriyabNachtharinee LaosirisathianChanun PunyoyaiSongyot AnuchapreedaSingkome TimaSawitree ChiampanichayakulWantida ChaiyanaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Suwannee Sriyab Nachtharinee Laosirisathian Chanun Punyoyai Songyot Anuchapreeda Singkome Tima Sawitree Chiampanichayakul Wantida Chaiyana Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor
description	Abstract This study aimed to investigate the nutricosmetic effect of Asparagus officinalis extracts. The tip and spear of A. officinalis were successively extracted with 95% ethanol. The rutin, phenolic, and flavonoid contents of A. officinalis extracts were investigated. The antioxidant activities were determined by 2,2-azinobis (3-ethylbenzothiazoline-6-sulphonic acid) and a ferric reducing antioxidant power assay. Matrix metalloproteinase-1 (MMP-1), elastase, and hyaluronidase inhibition were determined by in vitro enzyme reaction assay. The cytotoxicity was analyzed on peripheral blood mononuclear cellss. Findings revealed that drying temperature and drying duration had significant effects on the chemical composition and biological activity of A. officinalis extract. A. officinalis tips dried at 50 °C for 24 h contained the (significantly) highest flavonoid and rutin content. The most potent extract was from A. officinalis spears since it possessed the (significantly) highest MMP-1, elastase, and hyaluronidase inhibition rates of 83.4 ± 1.5%, 70.4 ± 4.1%, and 75.2 ± 1.0%, respectively. Interestingly, at the same concentration, the A. officinalis spear extract was more potent in MMP-1 inhibition than oleanolic acid and epigallocatechin gallate, the well-known natural MMP-1 inhibitors. The results show that A. officinalis extract is an attractive source of natural anti-skin-wrinkle ingredients.
format	article
author	Suwannee Sriyab Nachtharinee Laosirisathian Chanun Punyoyai Songyot Anuchapreeda Singkome Tima Sawitree Chiampanichayakul Wantida Chaiyana
author_facet	Suwannee Sriyab Nachtharinee Laosirisathian Chanun Punyoyai Songyot Anuchapreeda Singkome Tima Sawitree Chiampanichayakul Wantida Chaiyana
author_sort	Suwannee Sriyab
title	Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor
title_short	Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor
title_full	Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor
title_fullStr	Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor
title_full_unstemmed	Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor
title_sort	nutricosmetic effects of asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c55211e2a64946ec9b35c700f8cded78
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Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor

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