Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue

At the site of injury, macrophages exit their characteristic phenotype undergoing direct conversion to fibroblasts. Keratinocyte-derived miR-21, packaged in extracellular vesicles, enables such plasticity which accounts for the vast majority of all fibroblasts in the granulation tissue.

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Autores principales:	Mithun Sinha, Chandan K. Sen, Kanhaiya Singh, Amitava Das, Subhadip Ghatak, Brian Rhea, Britani Blackstone, Heather M. Powell, Savita Khanna, Sashwati Roy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c553b0019b7246a19d5e7cc2ac97f13c
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spelling	oai:doaj.org-article:c553b0019b7246a19d5e7cc2ac97f13c2021-12-02T15:34:22ZDirect conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue10.1038/s41467-018-03208-w2041-1723https://doaj.org/article/c553b0019b7246a19d5e7cc2ac97f13c2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03208-whttps://doaj.org/toc/2041-1723At the site of injury, macrophages exit their characteristic phenotype undergoing direct conversion to fibroblasts. Keratinocyte-derived miR-21, packaged in extracellular vesicles, enables such plasticity which accounts for the vast majority of all fibroblasts in the granulation tissue.Mithun SinhaChandan K. SenKanhaiya SinghAmitava DasSubhadip GhatakBrian RheaBritani BlackstoneHeather M. PowellSavita KhannaSashwati RoyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mithun Sinha Chandan K. Sen Kanhaiya Singh Amitava Das Subhadip Ghatak Brian Rhea Britani Blackstone Heather M. Powell Savita Khanna Sashwati Roy Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue
description	At the site of injury, macrophages exit their characteristic phenotype undergoing direct conversion to fibroblasts. Keratinocyte-derived miR-21, packaged in extracellular vesicles, enables such plasticity which accounts for the vast majority of all fibroblasts in the granulation tissue.
format	article
author	Mithun Sinha Chandan K. Sen Kanhaiya Singh Amitava Das Subhadip Ghatak Brian Rhea Britani Blackstone Heather M. Powell Savita Khanna Sashwati Roy
author_facet	Mithun Sinha Chandan K. Sen Kanhaiya Singh Amitava Das Subhadip Ghatak Brian Rhea Britani Blackstone Heather M. Powell Savita Khanna Sashwati Roy
author_sort	Mithun Sinha
title	Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue
title_short	Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue
title_full	Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue
title_fullStr	Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue
title_full_unstemmed	Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue
title_sort	direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c553b0019b7246a19d5e7cc2ac97f13c
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Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue

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