Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states

The interfollicular epidermis (IFE) is part of the epidermis but how it forms is unclear. Here, the authors perform scRNA sequencing at various developmental stages on the mouse epidermis and on deletion of Grhl3, showing IFE differentiation is gradual and that Grhl3 is needed for commitment to diff...

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Autores principales:	Ziguang Lin, Suoqin Jin, Jefferson Chen, Zhuorui Li, Zhongqi Lin, Li Tang, Qing Nie, Bogi Andersen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c5557fca52a74da19ba8e850221bae6e
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spelling	oai:doaj.org-article:c5557fca52a74da19ba8e850221bae6e2021-12-02T17:32:57ZMurine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states10.1038/s41467-020-19234-62041-1723https://doaj.org/article/c5557fca52a74da19ba8e850221bae6e2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19234-6https://doaj.org/toc/2041-1723The interfollicular epidermis (IFE) is part of the epidermis but how it forms is unclear. Here, the authors perform scRNA sequencing at various developmental stages on the mouse epidermis and on deletion of Grhl3, showing IFE differentiation is gradual and that Grhl3 is needed for commitment to differentiation by regulating Wnt signalling pathway.Ziguang LinSuoqin JinJefferson ChenZhuorui LiZhongqi LinLi TangQing NieBogi AndersenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ziguang Lin Suoqin Jin Jefferson Chen Zhuorui Li Zhongqi Lin Li Tang Qing Nie Bogi Andersen Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
description	The interfollicular epidermis (IFE) is part of the epidermis but how it forms is unclear. Here, the authors perform scRNA sequencing at various developmental stages on the mouse epidermis and on deletion of Grhl3, showing IFE differentiation is gradual and that Grhl3 is needed for commitment to differentiation by regulating Wnt signalling pathway.
format	article
author	Ziguang Lin Suoqin Jin Jefferson Chen Zhuorui Li Zhongqi Lin Li Tang Qing Nie Bogi Andersen
author_facet	Ziguang Lin Suoqin Jin Jefferson Chen Zhuorui Li Zhongqi Lin Li Tang Qing Nie Bogi Andersen
author_sort	Ziguang Lin
title	Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
title_short	Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
title_full	Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
title_fullStr	Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
title_full_unstemmed	Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
title_sort	murine interfollicular epidermal differentiation is gradualistic with grhl3 controlling progression from stem to transition cell states
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c5557fca52a74da19ba8e850221bae6e
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Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states

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