Changes in the brain microstructure of children with primary monosymptomatic nocturnal enuresis: a diffusion tensor imaging study.

<h4>Background</h4>Primary monosymptomatic nocturnal enuresis (PMNE) is a common disorder in school-aged children. Previous studies have suggested that a developmental delay might play a role in the pathology of children with PMNE. However, microstructural abnormalities in the brains of...

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Autores principales:	Du Lei, Jun Ma, Xiaoming Shen, Xiaoxia Du, Guohua Shen, Wei Liu, Xu Yan, Gengying Li
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c556cc72c57d401e8e4f2f8fd5695084
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spelling	oai:doaj.org-article:c556cc72c57d401e8e4f2f8fd56950842021-11-18T07:27:41ZChanges in the brain microstructure of children with primary monosymptomatic nocturnal enuresis: a diffusion tensor imaging study.1932-620310.1371/journal.pone.0031023https://doaj.org/article/c556cc72c57d401e8e4f2f8fd56950842012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22363538/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Primary monosymptomatic nocturnal enuresis (PMNE) is a common disorder in school-aged children. Previous studies have suggested that a developmental delay might play a role in the pathology of children with PMNE. However, microstructural abnormalities in the brains of these children have not been thoroughly investigated.<h4>Methodology/principal findings</h4>In this work, we evaluated structural changes in the brains of children with PMNE using diffusion tensor imaging (DTI). Two groups consisting of 26 children with PMNE and 26 healthy controls were scanned using magnetic resonance DTI. The diffusion parameters of fractional anisotropy (FA) and mean diffusivity (MD) were subjected to whole-brain, voxel-wise group comparisons using statistical parametric mapping (SPM). When compared to healthy subjects, children with PMNE showed both a decrease in FA and an increase in MD in the thalamus. MD also increased in the frontal lobe, the anterior cingulate cortex and the insula; these areas are all involved in controlling micturition. The significant changes seen in the thalamus could affect both urine storage and arousal from sleep.<h4>Conclusions/significance</h4>The microstructure abnormalities were observed in the thalamus, the medial frontal gyrus, the anterior cingulate cortex and the insula, which are involved in micturition control network. This indicates developmental delay in these areas may be the cause of PMNE.Du LeiJun MaXiaoming ShenXiaoxia DuGuohua ShenWei LiuXu YanGengying LiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e31023 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Du Lei Jun Ma Xiaoming Shen Xiaoxia Du Guohua Shen Wei Liu Xu Yan Gengying Li Changes in the brain microstructure of children with primary monosymptomatic nocturnal enuresis: a diffusion tensor imaging study.
description	<h4>Background</h4>Primary monosymptomatic nocturnal enuresis (PMNE) is a common disorder in school-aged children. Previous studies have suggested that a developmental delay might play a role in the pathology of children with PMNE. However, microstructural abnormalities in the brains of these children have not been thoroughly investigated.<h4>Methodology/principal findings</h4>In this work, we evaluated structural changes in the brains of children with PMNE using diffusion tensor imaging (DTI). Two groups consisting of 26 children with PMNE and 26 healthy controls were scanned using magnetic resonance DTI. The diffusion parameters of fractional anisotropy (FA) and mean diffusivity (MD) were subjected to whole-brain, voxel-wise group comparisons using statistical parametric mapping (SPM). When compared to healthy subjects, children with PMNE showed both a decrease in FA and an increase in MD in the thalamus. MD also increased in the frontal lobe, the anterior cingulate cortex and the insula; these areas are all involved in controlling micturition. The significant changes seen in the thalamus could affect both urine storage and arousal from sleep.<h4>Conclusions/significance</h4>The microstructure abnormalities were observed in the thalamus, the medial frontal gyrus, the anterior cingulate cortex and the insula, which are involved in micturition control network. This indicates developmental delay in these areas may be the cause of PMNE.
format	article
author	Du Lei Jun Ma Xiaoming Shen Xiaoxia Du Guohua Shen Wei Liu Xu Yan Gengying Li
author_facet	Du Lei Jun Ma Xiaoming Shen Xiaoxia Du Guohua Shen Wei Liu Xu Yan Gengying Li
author_sort	Du Lei
title	Changes in the brain microstructure of children with primary monosymptomatic nocturnal enuresis: a diffusion tensor imaging study.
title_short	Changes in the brain microstructure of children with primary monosymptomatic nocturnal enuresis: a diffusion tensor imaging study.
title_full	Changes in the brain microstructure of children with primary monosymptomatic nocturnal enuresis: a diffusion tensor imaging study.
title_fullStr	Changes in the brain microstructure of children with primary monosymptomatic nocturnal enuresis: a diffusion tensor imaging study.
title_full_unstemmed	Changes in the brain microstructure of children with primary monosymptomatic nocturnal enuresis: a diffusion tensor imaging study.
title_sort	changes in the brain microstructure of children with primary monosymptomatic nocturnal enuresis: a diffusion tensor imaging study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/c556cc72c57d401e8e4f2f8fd5695084
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Changes in the brain microstructure of children with primary monosymptomatic nocturnal enuresis: a diffusion tensor imaging study.

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