Endolysin, a Promising Solution against Antimicrobial Resistance

Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the effective prevention and control of ever-increasing infectious diseases. The advent of pandrug-resistant bacteria makes most, if not all, available antibiotics invalid. Meanwhile, the pipeline of novel anti...

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Autores principales:	Mujeeb ur Rahman, Weixiao Wang, Qingqing Sun, Junaid Ali Shah, Chao Li, Yanmei Sun, Yuanrui Li, Bailing Zhang, Wei Chen, Shiwei Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antimicrobial resistance endolysin biofilm food safety pathogen detection Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c55989edeb2f49c1a9222361f59cb220
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spelling	oai:doaj.org-article:c55989edeb2f49c1a9222361f59cb2202021-11-25T16:21:50ZEndolysin, a Promising Solution against Antimicrobial Resistance10.3390/antibiotics101112772079-6382https://doaj.org/article/c55989edeb2f49c1a9222361f59cb2202021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1277https://doaj.org/toc/2079-6382Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the effective prevention and control of ever-increasing infectious diseases. The advent of pandrug-resistant bacteria makes most, if not all, available antibiotics invalid. Meanwhile, the pipeline of novel antibiotics development stagnates, which prompts scientists and pharmacists to develop unconventional antimicrobials. Bacteriophage-derived endolysins are cell wall hydrolases which could hydrolyze the peptidoglycan layer from within and outside of bacterial pathogens. With high specificity, rapid action, high efficiency, and low risk of resistance development, endolysins are believed to be among the best alternative therapeutic agents to treat multidrug resistant (MDR) bacteria. As of now, endolysins have been applied to diverse aspects. In this review, we comprehensively introduce the structures and activities of endolysins and summarize the latest application progress of recombinant endolysins in the fields of medical treatment, pathogen diagnosis, food safety, and agriculture.Mujeeb ur RahmanWeixiao WangQingqing SunJunaid Ali ShahChao LiYanmei SunYuanrui LiBailing ZhangWei ChenShiwei WangMDPI AGarticleantimicrobial resistanceendolysinbiofilmfood safetypathogen detectionTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1277, p 1277 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial resistance endolysin biofilm food safety pathogen detection Therapeutics. Pharmacology RM1-950
spellingShingle	antimicrobial resistance endolysin biofilm food safety pathogen detection Therapeutics. Pharmacology RM1-950 Mujeeb ur Rahman Weixiao Wang Qingqing Sun Junaid Ali Shah Chao Li Yanmei Sun Yuanrui Li Bailing Zhang Wei Chen Shiwei Wang Endolysin, a Promising Solution against Antimicrobial Resistance
description	Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the effective prevention and control of ever-increasing infectious diseases. The advent of pandrug-resistant bacteria makes most, if not all, available antibiotics invalid. Meanwhile, the pipeline of novel antibiotics development stagnates, which prompts scientists and pharmacists to develop unconventional antimicrobials. Bacteriophage-derived endolysins are cell wall hydrolases which could hydrolyze the peptidoglycan layer from within and outside of bacterial pathogens. With high specificity, rapid action, high efficiency, and low risk of resistance development, endolysins are believed to be among the best alternative therapeutic agents to treat multidrug resistant (MDR) bacteria. As of now, endolysins have been applied to diverse aspects. In this review, we comprehensively introduce the structures and activities of endolysins and summarize the latest application progress of recombinant endolysins in the fields of medical treatment, pathogen diagnosis, food safety, and agriculture.
format	article
author	Mujeeb ur Rahman Weixiao Wang Qingqing Sun Junaid Ali Shah Chao Li Yanmei Sun Yuanrui Li Bailing Zhang Wei Chen Shiwei Wang
author_facet	Mujeeb ur Rahman Weixiao Wang Qingqing Sun Junaid Ali Shah Chao Li Yanmei Sun Yuanrui Li Bailing Zhang Wei Chen Shiwei Wang
author_sort	Mujeeb ur Rahman
title	Endolysin, a Promising Solution against Antimicrobial Resistance
title_short	Endolysin, a Promising Solution against Antimicrobial Resistance
title_full	Endolysin, a Promising Solution against Antimicrobial Resistance
title_fullStr	Endolysin, a Promising Solution against Antimicrobial Resistance
title_full_unstemmed	Endolysin, a Promising Solution against Antimicrobial Resistance
title_sort	endolysin, a promising solution against antimicrobial resistance
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c55989edeb2f49c1a9222361f59cb220
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Endolysin, a Promising Solution against Antimicrobial Resistance

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