Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
The host immune response plays a critical role in the immunopathology of SARS-CoV2. Here the authors combine a systems biology approach to implicate monocytes as key drivers of cytokine storm and disturbed neutrophil activation in COVID-19 disease severity.
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Nature Portfolio
2021
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oai:doaj.org-article:c55c079574c54862a899d42bf41ed8512021-12-02T15:23:18ZMonocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity10.1038/s41467-021-24360-w2041-1723https://doaj.org/article/c55c079574c54862a899d42bf41ed8512021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24360-whttps://doaj.org/toc/2041-1723The host immune response plays a critical role in the immunopathology of SARS-CoV2. Here the authors combine a systems biology approach to implicate monocytes as key drivers of cytokine storm and disturbed neutrophil activation in COVID-19 disease severity.L. VanderbekeP. Van MolY. Van HerckF. De SmetS. Humblet-BaronK. MartinodA. AntoranzI. ArijsB. BoeckxF. M. BosisioM. CasaerD. DauweW. De WeverC. DoomsE. DreesenA. EmmaneelJ. FiltjensM. GouwyJ. GunstG. HermansS. JansenK. LagrouA. ListonN. LorentP. MeerssemanT. MercierJ. NeytsJ. OdentD. PanovskaP. A. PenttilaE. PolletP. ProostJ. QianK. QuintelierJ. RaesS. RexY. SaeysJ. SprootenS. TejparD. TestelmansK. ThevissenT. Van BuytenJ. VandenhauteS. Van GassenL. C. Velásquez PereiraR. VosB. WeynandA. WilmerJ. YserbytA. D. GargP. MatthysC. WoutersD. LambrechtsE. WautersJ. WautersNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
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Science Q |
| spellingShingle |
Science Q L. Vanderbeke P. Van Mol Y. Van Herck F. De Smet S. Humblet-Baron K. Martinod A. Antoranz I. Arijs B. Boeckx F. M. Bosisio M. Casaer D. Dauwe W. De Wever C. Dooms E. Dreesen A. Emmaneel J. Filtjens M. Gouwy J. Gunst G. Hermans S. Jansen K. Lagrou A. Liston N. Lorent P. Meersseman T. Mercier J. Neyts J. Odent D. Panovska P. A. Penttila E. Pollet P. Proost J. Qian K. Quintelier J. Raes S. Rex Y. Saeys J. Sprooten S. Tejpar D. Testelmans K. Thevissen T. Van Buyten J. Vandenhaute S. Van Gassen L. C. Velásquez Pereira R. Vos B. Weynand A. Wilmer J. Yserbyt A. D. Garg P. Matthys C. Wouters D. Lambrechts E. Wauters J. Wauters Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity |
| description |
The host immune response plays a critical role in the immunopathology of SARS-CoV2. Here the authors combine a systems biology approach to implicate monocytes as key drivers of cytokine storm and disturbed neutrophil activation in COVID-19 disease severity. |
| format |
article |
| author |
L. Vanderbeke P. Van Mol Y. Van Herck F. De Smet S. Humblet-Baron K. Martinod A. Antoranz I. Arijs B. Boeckx F. M. Bosisio M. Casaer D. Dauwe W. De Wever C. Dooms E. Dreesen A. Emmaneel J. Filtjens M. Gouwy J. Gunst G. Hermans S. Jansen K. Lagrou A. Liston N. Lorent P. Meersseman T. Mercier J. Neyts J. Odent D. Panovska P. A. Penttila E. Pollet P. Proost J. Qian K. Quintelier J. Raes S. Rex Y. Saeys J. Sprooten S. Tejpar D. Testelmans K. Thevissen T. Van Buyten J. Vandenhaute S. Van Gassen L. C. Velásquez Pereira R. Vos B. Weynand A. Wilmer J. Yserbyt A. D. Garg P. Matthys C. Wouters D. Lambrechts E. Wauters J. Wauters |
| author_facet |
L. Vanderbeke P. Van Mol Y. Van Herck F. De Smet S. Humblet-Baron K. Martinod A. Antoranz I. Arijs B. Boeckx F. M. Bosisio M. Casaer D. Dauwe W. De Wever C. Dooms E. Dreesen A. Emmaneel J. Filtjens M. Gouwy J. Gunst G. Hermans S. Jansen K. Lagrou A. Liston N. Lorent P. Meersseman T. Mercier J. Neyts J. Odent D. Panovska P. A. Penttila E. Pollet P. Proost J. Qian K. Quintelier J. Raes S. Rex Y. Saeys J. Sprooten S. Tejpar D. Testelmans K. Thevissen T. Van Buyten J. Vandenhaute S. Van Gassen L. C. Velásquez Pereira R. Vos B. Weynand A. Wilmer J. Yserbyt A. D. Garg P. Matthys C. Wouters D. Lambrechts E. Wauters J. Wauters |
| author_sort |
L. Vanderbeke |
| title |
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity |
| title_short |
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity |
| title_full |
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity |
| title_fullStr |
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity |
| title_full_unstemmed |
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity |
| title_sort |
monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of covid-19 disease severity |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c55c079574c54862a899d42bf41ed851 |
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