Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity

Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity

The host immune response plays a critical role in the immunopathology of SARS-CoV2. Here the authors combine a systems biology approach to implicate monocytes as key drivers of cytokine storm and disturbed neutrophil activation in COVID-19 disease severity.

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Bibliographic Details
Main Authors: L. Vanderbeke, P. Van Mol, Y. Van Herck, F. De Smet, S. Humblet-Baron, K. Martinod, A. Antoranz, I. Arijs, B. Boeckx, F. M. Bosisio, M. Casaer, D. Dauwe, W. De Wever, C. Dooms, E. Dreesen, A. Emmaneel, J. Filtjens, M. Gouwy, J. Gunst, G. Hermans, S. Jansen, K. Lagrou, A. Liston, N. Lorent, P. Meersseman, T. Mercier, J. Neyts, J. Odent, D. Panovska, P. A. Penttila, E. Pollet, P. Proost, J. Qian, K. Quintelier, J. Raes, S. Rex, Y. Saeys, J. Sprooten, S. Tejpar, D. Testelmans, K. Thevissen, T. Van Buyten, J. Vandenhaute, S. Van Gassen, L. C. Velásquez Pereira, R. Vos, B. Weynand, A. Wilmer, J. Yserbyt, A. D. Garg, P. Matthys, C. Wouters, D. Lambrechts, E. Wauters, J. Wauters
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
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Online Access:https://doaj.org/article/c55c079574c54862a899d42bf41ed851
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https://doaj.org/article/c55c079574c54862a899d42bf41ed851

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