LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription

The regenerating islet-derived (REG) protein family suppresses cell death and promotes cell proliferation. Here the authors report that the lncRNA REG1CP forms an RNA–DNA triplex at the promoter of REG3A gene to increase its expression.

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Autores principales:	Hamed Yari, Lei Jin, Liu Teng, Yufang Wang, Yongyan Wu, Guang Zhi Liu, Wei Gao, Jin Liang, Yanfeng Xi, Yu Chen Feng, Chunming Zhang, Yuan Yuan Zhang, Hessam Tabatabaee, Ting La, Rui Hong Yang, Fu Hua Wang, Xu Guang Yan, Margaret Farrelly, Rodney Scott, Tao Liu, Rick F. Thorne, Su Tang Guo, Xu Dong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c55d93947a734bacbb45ea1a22e7ea16
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spelling	oai:doaj.org-article:c55d93947a734bacbb45ea1a22e7ea162021-12-02T15:35:40ZLncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription10.1038/s41467-019-13313-z2041-1723https://doaj.org/article/c55d93947a734bacbb45ea1a22e7ea162019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13313-zhttps://doaj.org/toc/2041-1723The regenerating islet-derived (REG) protein family suppresses cell death and promotes cell proliferation. Here the authors report that the lncRNA REG1CP forms an RNA–DNA triplex at the promoter of REG3A gene to increase its expression.Hamed YariLei JinLiu TengYufang WangYongyan WuGuang Zhi LiuWei GaoJin LiangYanfeng XiYu Chen FengChunming ZhangYuan Yuan ZhangHessam TabatabaeeTing LaRui Hong YangFu Hua WangXu Guang YanMargaret FarrellyRodney ScottTao LiuRick F. ThorneSu Tang GuoXu Dong ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hamed Yari Lei Jin Liu Teng Yufang Wang Yongyan Wu Guang Zhi Liu Wei Gao Jin Liang Yanfeng Xi Yu Chen Feng Chunming Zhang Yuan Yuan Zhang Hessam Tabatabaee Ting La Rui Hong Yang Fu Hua Wang Xu Guang Yan Margaret Farrelly Rodney Scott Tao Liu Rick F. Thorne Su Tang Guo Xu Dong Zhang LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription
description	The regenerating islet-derived (REG) protein family suppresses cell death and promotes cell proliferation. Here the authors report that the lncRNA REG1CP forms an RNA–DNA triplex at the promoter of REG3A gene to increase its expression.
format	article
author	Hamed Yari Lei Jin Liu Teng Yufang Wang Yongyan Wu Guang Zhi Liu Wei Gao Jin Liang Yanfeng Xi Yu Chen Feng Chunming Zhang Yuan Yuan Zhang Hessam Tabatabaee Ting La Rui Hong Yang Fu Hua Wang Xu Guang Yan Margaret Farrelly Rodney Scott Tao Liu Rick F. Thorne Su Tang Guo Xu Dong Zhang
author_facet	Hamed Yari Lei Jin Liu Teng Yufang Wang Yongyan Wu Guang Zhi Liu Wei Gao Jin Liang Yanfeng Xi Yu Chen Feng Chunming Zhang Yuan Yuan Zhang Hessam Tabatabaee Ting La Rui Hong Yang Fu Hua Wang Xu Guang Yan Margaret Farrelly Rodney Scott Tao Liu Rick F. Thorne Su Tang Guo Xu Dong Zhang
author_sort	Hamed Yari
title	LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription
title_short	LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription
title_full	LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription
title_fullStr	LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription
title_full_unstemmed	LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription
title_sort	lncrna reg1cp promotes tumorigenesis through an enhancer complex to recruit fancj helicase for reg3a transcription
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c55d93947a734bacbb45ea1a22e7ea16
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LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription

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