Minimum epistasis interpolation for sequence-function relationships

High-throughput combinatorial mutagenesis assays are useful to screen the function of many different sequences but they are not exhaustive. Here, Zhou and McCandlish develop a method to impute such missing genotype-phenotype data based on inferring the least epistatic sequence-function relationship.

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Detalles Bibliográficos
Autores principales:	Juannan Zhou, David M. McCandlish
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c55fc67817d342c78e06035001e72714
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spelling	oai:doaj.org-article:c55fc67817d342c78e06035001e727142021-12-02T17:32:40ZMinimum epistasis interpolation for sequence-function relationships10.1038/s41467-020-15512-52041-1723https://doaj.org/article/c55fc67817d342c78e06035001e727142020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15512-5https://doaj.org/toc/2041-1723High-throughput combinatorial mutagenesis assays are useful to screen the function of many different sequences but they are not exhaustive. Here, Zhou and McCandlish develop a method to impute such missing genotype-phenotype data based on inferring the least epistatic sequence-function relationship.Juannan ZhouDavid M. McCandlishNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Juannan Zhou David M. McCandlish Minimum epistasis interpolation for sequence-function relationships
description	High-throughput combinatorial mutagenesis assays are useful to screen the function of many different sequences but they are not exhaustive. Here, Zhou and McCandlish develop a method to impute such missing genotype-phenotype data based on inferring the least epistatic sequence-function relationship.
format	article
author	Juannan Zhou David M. McCandlish
author_facet	Juannan Zhou David M. McCandlish
author_sort	Juannan Zhou
title	Minimum epistasis interpolation for sequence-function relationships
title_short	Minimum epistasis interpolation for sequence-function relationships
title_full	Minimum epistasis interpolation for sequence-function relationships
title_fullStr	Minimum epistasis interpolation for sequence-function relationships
title_full_unstemmed	Minimum epistasis interpolation for sequence-function relationships
title_sort	minimum epistasis interpolation for sequence-function relationships
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c55fc67817d342c78e06035001e72714
work_keys_str_mv	AT juannanzhou minimumepistasisinterpolationforsequencefunctionrelationships AT davidmmccandlish minimumepistasisinterpolationforsequencefunctionrelationships
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Minimum epistasis interpolation for sequence-function relationships

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