c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression

HGF/c-MET upregulation is frequent in bladder cancer. Here, the authors show that HGF induces EMT and invasion by stabilising TGFβ receptor through inhibition of the SMURF2 ligase, and the combined blockade of MAPK and TGFβ pathways suppresses HGF-mediated bladder cancer progression.

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Detalles Bibliográficos
Autores principales: Wen Jing Sim, Prasanna Vasudevan Iyengar, Dilraj Lama, Sarah Kit Leng Lui, Hsien Chun Ng, Lior Haviv-Shapira, Eytan Domany, Dennis Kappei, Tuan Zea Tan, Azad Saei, Patrick William Jaynes, Chandra Shekhar Verma, Alan Prem Kumar, Mathieu Rouanne, Hong Koo Ha, Camelia Radulescu, Peter ten Dijke, Pieter Johan Adam Eichhorn, Jean Paul Thiery
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/c563b6db7c52440f8cb6c74048d684b4
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Descripción
Sumario:HGF/c-MET upregulation is frequent in bladder cancer. Here, the authors show that HGF induces EMT and invasion by stabilising TGFβ receptor through inhibition of the SMURF2 ligase, and the combined blockade of MAPK and TGFβ pathways suppresses HGF-mediated bladder cancer progression.

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