c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression
HGF/c-MET upregulation is frequent in bladder cancer. Here, the authors show that HGF induces EMT and invasion by stabilising TGFβ receptor through inhibition of the SMURF2 ligase, and the combined blockade of MAPK and TGFβ pathways suppresses HGF-mediated bladder cancer progression.
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Nature Portfolio
2019
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| Acceso en línea: | https://doaj.org/article/c563b6db7c52440f8cb6c74048d684b4 |
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oai:doaj.org-article:c563b6db7c52440f8cb6c74048d684b42021-12-02T16:58:27Zc-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression10.1038/s41467-019-12241-22041-1723https://doaj.org/article/c563b6db7c52440f8cb6c74048d684b42019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12241-2https://doaj.org/toc/2041-1723HGF/c-MET upregulation is frequent in bladder cancer. Here, the authors show that HGF induces EMT and invasion by stabilising TGFβ receptor through inhibition of the SMURF2 ligase, and the combined blockade of MAPK and TGFβ pathways suppresses HGF-mediated bladder cancer progression.Wen Jing SimPrasanna Vasudevan IyengarDilraj LamaSarah Kit Leng LuiHsien Chun NgLior Haviv-ShapiraEytan DomanyDennis KappeiTuan Zea TanAzad SaeiPatrick William JaynesChandra Shekhar VermaAlan Prem KumarMathieu RouanneHong Koo HaCamelia RadulescuPeter ten DijkePieter Johan Adam EichhornJean Paul ThieryNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Wen Jing Sim Prasanna Vasudevan Iyengar Dilraj Lama Sarah Kit Leng Lui Hsien Chun Ng Lior Haviv-Shapira Eytan Domany Dennis Kappei Tuan Zea Tan Azad Saei Patrick William Jaynes Chandra Shekhar Verma Alan Prem Kumar Mathieu Rouanne Hong Koo Ha Camelia Radulescu Peter ten Dijke Pieter Johan Adam Eichhorn Jean Paul Thiery c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression |
| description |
HGF/c-MET upregulation is frequent in bladder cancer. Here, the authors show that HGF induces EMT and invasion by stabilising TGFβ receptor through inhibition of the SMURF2 ligase, and the combined blockade of MAPK and TGFβ pathways suppresses HGF-mediated bladder cancer progression. |
| format |
article |
| author |
Wen Jing Sim Prasanna Vasudevan Iyengar Dilraj Lama Sarah Kit Leng Lui Hsien Chun Ng Lior Haviv-Shapira Eytan Domany Dennis Kappei Tuan Zea Tan Azad Saei Patrick William Jaynes Chandra Shekhar Verma Alan Prem Kumar Mathieu Rouanne Hong Koo Ha Camelia Radulescu Peter ten Dijke Pieter Johan Adam Eichhorn Jean Paul Thiery |
| author_facet |
Wen Jing Sim Prasanna Vasudevan Iyengar Dilraj Lama Sarah Kit Leng Lui Hsien Chun Ng Lior Haviv-Shapira Eytan Domany Dennis Kappei Tuan Zea Tan Azad Saei Patrick William Jaynes Chandra Shekhar Verma Alan Prem Kumar Mathieu Rouanne Hong Koo Ha Camelia Radulescu Peter ten Dijke Pieter Johan Adam Eichhorn Jean Paul Thiery |
| author_sort |
Wen Jing Sim |
| title |
c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression |
| title_short |
c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression |
| title_full |
c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression |
| title_fullStr |
c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression |
| title_full_unstemmed |
c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression |
| title_sort |
c-met activation leads to the establishment of a tgfβ-receptor regulatory network in bladder cancer progression |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/c563b6db7c52440f8cb6c74048d684b4 |
| work_keys_str_mv |
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| _version_ |
1718382293900328960 |