TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum

Objectives. Compared to type 1 diabetes, the role of the immune and autoimmune pathogenetic mechanisms is much less studied in the type 2 diabetes. Toll-like receptors 4 (TLR4) have a leading role in inflammation, insulin resistance, and vascular damage. This study aimed to analyze the relationship...

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Autores principales:	Zaharieva ET, Kamenov ZA, Savov AS
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2017
Materias:	type 2 diabetes prediabetes diabetic complications toll-like receptor 4 single nucleotide polymorphism innate immune response Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/c56a992a0322481092b30cab471f7d0a
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spelling	oai:doaj.org-article:c56a992a0322481092b30cab471f7d0a2021-12-02T16:33:01ZTLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum1336-032910.1515/enr-2017-0014https://doaj.org/article/c56a992a0322481092b30cab471f7d0a2017-07-01T00:00:00Zhttps://doi.org/10.1515/enr-2017-0014https://doaj.org/toc/1336-0329Objectives. Compared to type 1 diabetes, the role of the immune and autoimmune pathogenetic mechanisms is much less studied in the type 2 diabetes. Toll-like receptors 4 (TLR4) have a leading role in inflammation, insulin resistance, and vascular damage. This study aimed to analyze the relationship between the polymorphisms in TLR4 gene and different stages in the glucose continuum from prediabetes to the type 2 diabetes and chronic microvascular complications.Zaharieva ETKamenov ZASavov ASSciendoarticletype 2 diabetesprediabetesdiabetic complicationstoll-like receptor 4single nucleotide polymorphisminnate immune responseDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 51, Iss 3, Pp 137-144 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 2 diabetes prediabetes diabetic complications toll-like receptor 4 single nucleotide polymorphism innate immune response Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	type 2 diabetes prediabetes diabetic complications toll-like receptor 4 single nucleotide polymorphism innate immune response Diseases of the endocrine glands. Clinical endocrinology RC648-665 Zaharieva ET Kamenov ZA Savov AS TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum
description	Objectives. Compared to type 1 diabetes, the role of the immune and autoimmune pathogenetic mechanisms is much less studied in the type 2 diabetes. Toll-like receptors 4 (TLR4) have a leading role in inflammation, insulin resistance, and vascular damage. This study aimed to analyze the relationship between the polymorphisms in TLR4 gene and different stages in the glucose continuum from prediabetes to the type 2 diabetes and chronic microvascular complications.
format	article
author	Zaharieva ET Kamenov ZA Savov AS
author_facet	Zaharieva ET Kamenov ZA Savov AS
author_sort	Zaharieva ET
title	TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum
title_short	TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum
title_full	TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum
title_fullStr	TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum
title_full_unstemmed	TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum
title_sort	tlr4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; tlr4 polymorphisms in glucose continuum
publisher	Sciendo
publishDate	2017
url	https://doaj.org/article/c56a992a0322481092b30cab471f7d0a
work_keys_str_mv	AT zaharievaet tlr4polymorphismsseemnottobeassociatedwithprediabetesandtype2diabetesbutpredisposetodiabeticretinopathytlr4polymorphismsinglucosecontinuum AT kamenovza tlr4polymorphismsseemnottobeassociatedwithprediabetesandtype2diabetesbutpredisposetodiabeticretinopathytlr4polymorphismsinglucosecontinuum AT savovas tlr4polymorphismsseemnottobeassociatedwithprediabetesandtype2diabetesbutpredisposetodiabeticretinopathytlr4polymorphismsinglucosecontinuum
_version_	1718383779156852736

TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum

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