Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
Injury repair is characterized by the generation of transient cell states important for tissue recovery. Here, the authors present a single cell RNA-seq map of recovery from bleomycin lung injury in mice and uncover a Krt8+ transitional stem cell state that precedes the regeneration of AT1 cells and...
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Nature Portfolio
2020
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oai:doaj.org-article:c56bf52cb142499c98ef8cc384553dbe2021-12-02T15:33:17ZAlveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis10.1038/s41467-020-17358-32041-1723https://doaj.org/article/c56bf52cb142499c98ef8cc384553dbe2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17358-3https://doaj.org/toc/2041-1723Injury repair is characterized by the generation of transient cell states important for tissue recovery. Here, the authors present a single cell RNA-seq map of recovery from bleomycin lung injury in mice and uncover a Krt8+ transitional stem cell state that precedes the regeneration of AT1 cells and persists in human lung fibrosis.Maximilian StrunzLukas M. SimonMeshal AnsariJaymin J. KathiriyaIlias AngelidisChristoph H. MayrGeorge TsidiridisMarius LangeLaura F. MattnerMin YeePaulina OgarArunima SenguptaIgor KukhtevichRobert SchneiderZhongming ZhaoCarola VossTobias StoegerJens H. L. NeumannAnne HilgendorffJürgen BehrMichael O’ReillyMareike LehmannGerald BurgstallerMelanie KönigshoffHarold A. ChapmanFabian J. TheisHerbert B. SchillerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020) |
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EN |
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Science Q |
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Science Q Maximilian Strunz Lukas M. Simon Meshal Ansari Jaymin J. Kathiriya Ilias Angelidis Christoph H. Mayr George Tsidiridis Marius Lange Laura F. Mattner Min Yee Paulina Ogar Arunima Sengupta Igor Kukhtevich Robert Schneider Zhongming Zhao Carola Voss Tobias Stoeger Jens H. L. Neumann Anne Hilgendorff Jürgen Behr Michael O’Reilly Mareike Lehmann Gerald Burgstaller Melanie Königshoff Harold A. Chapman Fabian J. Theis Herbert B. Schiller Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis |
| description |
Injury repair is characterized by the generation of transient cell states important for tissue recovery. Here, the authors present a single cell RNA-seq map of recovery from bleomycin lung injury in mice and uncover a Krt8+ transitional stem cell state that precedes the regeneration of AT1 cells and persists in human lung fibrosis. |
| format |
article |
| author |
Maximilian Strunz Lukas M. Simon Meshal Ansari Jaymin J. Kathiriya Ilias Angelidis Christoph H. Mayr George Tsidiridis Marius Lange Laura F. Mattner Min Yee Paulina Ogar Arunima Sengupta Igor Kukhtevich Robert Schneider Zhongming Zhao Carola Voss Tobias Stoeger Jens H. L. Neumann Anne Hilgendorff Jürgen Behr Michael O’Reilly Mareike Lehmann Gerald Burgstaller Melanie Königshoff Harold A. Chapman Fabian J. Theis Herbert B. Schiller |
| author_facet |
Maximilian Strunz Lukas M. Simon Meshal Ansari Jaymin J. Kathiriya Ilias Angelidis Christoph H. Mayr George Tsidiridis Marius Lange Laura F. Mattner Min Yee Paulina Ogar Arunima Sengupta Igor Kukhtevich Robert Schneider Zhongming Zhao Carola Voss Tobias Stoeger Jens H. L. Neumann Anne Hilgendorff Jürgen Behr Michael O’Reilly Mareike Lehmann Gerald Burgstaller Melanie Königshoff Harold A. Chapman Fabian J. Theis Herbert B. Schiller |
| author_sort |
Maximilian Strunz |
| title |
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis |
| title_short |
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis |
| title_full |
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis |
| title_fullStr |
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis |
| title_full_unstemmed |
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis |
| title_sort |
alveolar regeneration through a krt8+ transitional stem cell state that persists in human lung fibrosis |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/c56bf52cb142499c98ef8cc384553dbe |
| work_keys_str_mv |
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| _version_ |
1718387106582102016 |