Programmable Removal of Bacterial Strains by Use of Genome-Targeting CRISPR-Cas Systems

ABSTRACT CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) systems in bacteria and archaea employ CRISPR RNAs to specifically recognize the complementary DNA of foreign invaders, leading to sequence-specific cleavage or degradation of the target DNA. Recent w...

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Bibliographic Details
Main Authors: Ahmed A. Gomaa, Heidi E. Klumpe, Michelle L. Luo, Kurt Selle, Rodolphe Barrangou, Chase L. Beisel
Format: article
Language:EN
Published: American Society for Microbiology 2014
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Online Access:https://doaj.org/article/c576f41a762341faa31fc570780b6d0d
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