The impact of exposure to cafeteria diet during pregnancy or lactation on offspring growth and adiposity before weaning

Abstract Exposure to maternal obesity during early-life can have adverse consequences for offspring growth and adiposity. We aimed to assess the relative contributions of exposure to maternal obesity, induced by a highly varied cafeteria diet, during pregnancy and lactation on these measures in rat...

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Autores principales:	Grace George, Sally A. V. Draycott, Ronan Muir, Bethan Clifford, Matthew J. Elmes, Simon C. Langley-Evans
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c576f8262b8e4b8a809fe60eb718c408
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spelling	oai:doaj.org-article:c576f8262b8e4b8a809fe60eb718c4082021-12-02T15:09:31ZThe impact of exposure to cafeteria diet during pregnancy or lactation on offspring growth and adiposity before weaning10.1038/s41598-019-50448-x2045-2322https://doaj.org/article/c576f8262b8e4b8a809fe60eb718c4082019-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-50448-xhttps://doaj.org/toc/2045-2322Abstract Exposure to maternal obesity during early-life can have adverse consequences for offspring growth and adiposity. We aimed to assess the relative contributions of exposure to maternal obesity, induced by a highly varied cafeteria diet, during pregnancy and lactation on these measures in rat offspring prior to weaning. Female Wistar rats were fed either a control (C) or cafeteria diet (O) for 8 weeks before mating, throughout pregnancy and lactation. Offspring were cross-fostered at birth to a dam on the same (CC,OO) or alternate diet prior to birth (CO,OC). Feeding a cafeteria diet based on 40 different foods, was associated with a sustained period of elevated energy intake before birth and during lactation (up to 1.7-fold), through increased sugar, total fat and saturated fat intake, and lower protein consumption. Cafeteria fed dams sustained greater weight than animals fed a control chow diet and greater perirenal adiposity by the end of lactation. Exposure to obesity during pregnancy was associated with lower offspring birth weight and body weight in early-postnatal life. In contrast, exposure during lactation alone reduced offspring weight but increased adiposity in male CO offspring before weaning. This research highlights that exposure to maternal obesity during lactation alone can programme adiposity in a sex specific manner.Grace GeorgeSally A. V. DraycottRonan MuirBethan CliffordMatthew J. ElmesSimon C. Langley-EvansNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Grace George Sally A. V. Draycott Ronan Muir Bethan Clifford Matthew J. Elmes Simon C. Langley-Evans The impact of exposure to cafeteria diet during pregnancy or lactation on offspring growth and adiposity before weaning
description	Abstract Exposure to maternal obesity during early-life can have adverse consequences for offspring growth and adiposity. We aimed to assess the relative contributions of exposure to maternal obesity, induced by a highly varied cafeteria diet, during pregnancy and lactation on these measures in rat offspring prior to weaning. Female Wistar rats were fed either a control (C) or cafeteria diet (O) for 8 weeks before mating, throughout pregnancy and lactation. Offspring were cross-fostered at birth to a dam on the same (CC,OO) or alternate diet prior to birth (CO,OC). Feeding a cafeteria diet based on 40 different foods, was associated with a sustained period of elevated energy intake before birth and during lactation (up to 1.7-fold), through increased sugar, total fat and saturated fat intake, and lower protein consumption. Cafeteria fed dams sustained greater weight than animals fed a control chow diet and greater perirenal adiposity by the end of lactation. Exposure to obesity during pregnancy was associated with lower offspring birth weight and body weight in early-postnatal life. In contrast, exposure during lactation alone reduced offspring weight but increased adiposity in male CO offspring before weaning. This research highlights that exposure to maternal obesity during lactation alone can programme adiposity in a sex specific manner.
format	article
author	Grace George Sally A. V. Draycott Ronan Muir Bethan Clifford Matthew J. Elmes Simon C. Langley-Evans
author_facet	Grace George Sally A. V. Draycott Ronan Muir Bethan Clifford Matthew J. Elmes Simon C. Langley-Evans
author_sort	Grace George
title	The impact of exposure to cafeteria diet during pregnancy or lactation on offspring growth and adiposity before weaning
title_short	The impact of exposure to cafeteria diet during pregnancy or lactation on offspring growth and adiposity before weaning
title_full	The impact of exposure to cafeteria diet during pregnancy or lactation on offspring growth and adiposity before weaning
title_fullStr	The impact of exposure to cafeteria diet during pregnancy or lactation on offspring growth and adiposity before weaning
title_full_unstemmed	The impact of exposure to cafeteria diet during pregnancy or lactation on offspring growth and adiposity before weaning
title_sort	impact of exposure to cafeteria diet during pregnancy or lactation on offspring growth and adiposity before weaning
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c576f8262b8e4b8a809fe60eb718c408
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The impact of exposure to cafeteria diet during pregnancy or lactation on offspring growth and adiposity before weaning

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