Subverting ER-stress towards apoptosis by nelfinavir and curcumin coexposure augments docetaxel efficacy in castration resistant prostate cancer cells.

Subverting ER-stress towards apoptosis by nelfinavir and curcumin coexposure augments docetaxel efficacy in castration resistant prostate cancer cells.

Despite its side-effects, docetaxel (DTX) remains a first-line treatment against castration resistant prostate cancer (CRPC). Therefore, strategies to increase its anti-tumor efficacy and decrease its side effects are critically needed. Targeting of the constitutive endoplasmic reticulum (ER) stress...

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Bibliographic Details
Main Authors: Aditi Mathur, Zakaria Y Abd Elmageed, Xichun Liu, Mikhail L Kostochka, Haitao Zhang, Asim B Abdel-Mageed, Debasis Mondal
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/c576fcb9a84b473ea65d5f1e6222c0e2
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https://doaj.org/article/c576fcb9a84b473ea65d5f1e6222c0e2

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