Inflammation and oxidative stress markers in diabetes and hypertension

Chloé Pouvreau,1 Antoine Dayre,1 Eugene G Butkowski,2 Beverlie de Jong,2 Herbert F Jelinek2,3 1Faculty of Sciences, University of Poitiers, Poitiers, France; 2School of Community Health, Charles Sturt University, Albury, NSW, Australia; 3Australian School of Advanced Medicine, Macquarie U...

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Autores principales:	Pouvreau C, Dayre A, Butkowski EG, de Jong B, Jelinek HF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Hypertension type 2 diabetes mellitus inflammation oxidative stress biomarkers Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c5784b1cafc449039d60550d0f138de3
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spelling	oai:doaj.org-article:c5784b1cafc449039d60550d0f138de32021-12-02T05:01:00ZInflammation and oxidative stress markers in diabetes and hypertension1178-7031https://doaj.org/article/c5784b1cafc449039d60550d0f138de32018-02-01T00:00:00Zhttps://www.dovepress.com/inflammation-and-oxidative-stress-markers-in-diabetes-and-hypertension-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Chloé Pouvreau,1 Antoine Dayre,1 Eugene G Butkowski,2 Beverlie de Jong,2 Herbert F Jelinek2,3 1Faculty of Sciences, University of Poitiers, Poitiers, France; 2School of Community Health, Charles Sturt University, Albury, NSW, Australia; 3Australian School of Advanced Medicine, Macquarie University, Sydney, NSW, Australia Background: Inflammation and oxidative stress are important factors associated with chronic disease such as essential hypertension (HTN) and type 2 diabetes mellitus (T2DM). However, the association of inflammation and oxidative stress in HTN with T2DM as a comorbidity is inconclusive due to the multifactorial nature of these cardiometabolic diseases. Methodology: The influence of pathophysiological factors include genetics, age of patient, and disease progression change throughout the lifespan and require further investigation. The study population included 256 participants attending a rural health screening program who were tested for markers of inflammation, oxidative stress, and coagulation/fibrinolysis. Demographic and clinical variables included, age, gender, systolic and diastolic blood pressures, blood glucose, hemoglobin A1c, estimated glomerular filtration rate, and cholesterol profile. Data were tested for normality, and nonparametric statistics were applied to analyze the sample with significance set at p<0.05. Results: Of the inflammatory markers, interleukin-1β (IL-1β) and IL-10 were significantly different between the control and hypertensive group (p<0.03) and between the HTN+T2DM compared to the HTN group (p<0.05). Significant results for oxidative stress were observed for urinary 8-iso-PGF2α and insulin-like growth factor 1 (IGF-1) between the control and the HTN+T2DM group (p<0.01). Glutathione (GSH) was also significant between the HTN and HTN+T2DM group (p<0.05). Investigation of the progression of HTN also found significant changes in the inflammatory markers IGF-1, monocyte chemoattractant protein 1 (MCP-1), and (MCP-1/IGF-1)*IL-6 (p<0.05). Conclusion: This study demonstrated that 8-iso-PGF2α and erythrocyte GSH may be clinically useful for assessing HTN and HTN with T2DM as a comorbidity, while significant changes in the inflammatory profile were also observed with HTN progression. Keywords: hypertension, type 2 diabetes mellitus, inflammation, oxidative stress, biomarkersPouvreau CDayre AButkowski EGde Jong BJelinek HFDove Medical PressarticleHypertensiontype 2 diabetes mellitusinflammationoxidative stressbiomarkersPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 11, Pp 61-68 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hypertension type 2 diabetes mellitus inflammation oxidative stress biomarkers Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Hypertension type 2 diabetes mellitus inflammation oxidative stress biomarkers Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Pouvreau C Dayre A Butkowski EG de Jong B Jelinek HF Inflammation and oxidative stress markers in diabetes and hypertension
description	Chloé Pouvreau,1 Antoine Dayre,1 Eugene G Butkowski,2 Beverlie de Jong,2 Herbert F Jelinek2,3 1Faculty of Sciences, University of Poitiers, Poitiers, France; 2School of Community Health, Charles Sturt University, Albury, NSW, Australia; 3Australian School of Advanced Medicine, Macquarie University, Sydney, NSW, Australia Background: Inflammation and oxidative stress are important factors associated with chronic disease such as essential hypertension (HTN) and type 2 diabetes mellitus (T2DM). However, the association of inflammation and oxidative stress in HTN with T2DM as a comorbidity is inconclusive due to the multifactorial nature of these cardiometabolic diseases. Methodology: The influence of pathophysiological factors include genetics, age of patient, and disease progression change throughout the lifespan and require further investigation. The study population included 256 participants attending a rural health screening program who were tested for markers of inflammation, oxidative stress, and coagulation/fibrinolysis. Demographic and clinical variables included, age, gender, systolic and diastolic blood pressures, blood glucose, hemoglobin A1c, estimated glomerular filtration rate, and cholesterol profile. Data were tested for normality, and nonparametric statistics were applied to analyze the sample with significance set at p<0.05. Results: Of the inflammatory markers, interleukin-1β (IL-1β) and IL-10 were significantly different between the control and hypertensive group (p<0.03) and between the HTN+T2DM compared to the HTN group (p<0.05). Significant results for oxidative stress were observed for urinary 8-iso-PGF2α and insulin-like growth factor 1 (IGF-1) between the control and the HTN+T2DM group (p<0.01). Glutathione (GSH) was also significant between the HTN and HTN+T2DM group (p<0.05). Investigation of the progression of HTN also found significant changes in the inflammatory markers IGF-1, monocyte chemoattractant protein 1 (MCP-1), and (MCP-1/IGF-1)*IL-6 (p<0.05). Conclusion: This study demonstrated that 8-iso-PGF2α and erythrocyte GSH may be clinically useful for assessing HTN and HTN with T2DM as a comorbidity, while significant changes in the inflammatory profile were also observed with HTN progression. Keywords: hypertension, type 2 diabetes mellitus, inflammation, oxidative stress, biomarkers
format	article
author	Pouvreau C Dayre A Butkowski EG de Jong B Jelinek HF
author_facet	Pouvreau C Dayre A Butkowski EG de Jong B Jelinek HF
author_sort	Pouvreau C
title	Inflammation and oxidative stress markers in diabetes and hypertension
title_short	Inflammation and oxidative stress markers in diabetes and hypertension
title_full	Inflammation and oxidative stress markers in diabetes and hypertension
title_fullStr	Inflammation and oxidative stress markers in diabetes and hypertension
title_full_unstemmed	Inflammation and oxidative stress markers in diabetes and hypertension
title_sort	inflammation and oxidative stress markers in diabetes and hypertension
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/c5784b1cafc449039d60550d0f138de3
work_keys_str_mv	AT pouvreauc inflammationandoxidativestressmarkersindiabetesandhypertension AT dayrea inflammationandoxidativestressmarkersindiabetesandhypertension AT butkowskieg inflammationandoxidativestressmarkersindiabetesandhypertension AT dejongb inflammationandoxidativestressmarkersindiabetesandhypertension AT jelinekhf inflammationandoxidativestressmarkersindiabetesandhypertension
_version_	1718400852559921152

Inflammation and oxidative stress markers in diabetes and hypertension

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