Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations

Abstract Learning about context is essential for appropriate behavioral strategies, but important contingencies may not arise during initial learning. A variant of contextual fear conditioning, context pre-exposure facilitation, allows us to directly test the relationship between novelty-induced ace...

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Autores principales:	Sarah Hersman, Jesse Cushman, Noah Lemelson, Kate Wassum, Shahrdad Lotfipour, Michael S. Fanselow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c57996a3fc624abba2c492e3c3a6b4c9
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spelling	oai:doaj.org-article:c57996a3fc624abba2c492e3c3a6b4c92021-12-02T11:40:32ZOptogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations10.1038/s41598-017-02542-12045-2322https://doaj.org/article/c57996a3fc624abba2c492e3c3a6b4c92017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02542-1https://doaj.org/toc/2045-2322Abstract Learning about context is essential for appropriate behavioral strategies, but important contingencies may not arise during initial learning. A variant of contextual fear conditioning, context pre-exposure facilitation, allows us to directly test the relationship between novelty-induced acetylcholine release and later contextual associability. We demonstrate that optogenetically-enhanced acetylcholine during initial contextual exploration leads to stronger fear after subsequent pairing with shock, suggesting that novelty-induced acetylcholine release primes future contextual associations.Sarah HersmanJesse CushmanNoah LemelsonKate WassumShahrdad LotfipourMichael S. FanselowNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sarah Hersman Jesse Cushman Noah Lemelson Kate Wassum Shahrdad Lotfipour Michael S. Fanselow Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations
description	Abstract Learning about context is essential for appropriate behavioral strategies, but important contingencies may not arise during initial learning. A variant of contextual fear conditioning, context pre-exposure facilitation, allows us to directly test the relationship between novelty-induced acetylcholine release and later contextual associability. We demonstrate that optogenetically-enhanced acetylcholine during initial contextual exploration leads to stronger fear after subsequent pairing with shock, suggesting that novelty-induced acetylcholine release primes future contextual associations.
format	article
author	Sarah Hersman Jesse Cushman Noah Lemelson Kate Wassum Shahrdad Lotfipour Michael S. Fanselow
author_facet	Sarah Hersman Jesse Cushman Noah Lemelson Kate Wassum Shahrdad Lotfipour Michael S. Fanselow
author_sort	Sarah Hersman
title	Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations
title_short	Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations
title_full	Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations
title_fullStr	Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations
title_full_unstemmed	Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations
title_sort	optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c57996a3fc624abba2c492e3c3a6b4c9
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_version_	1718395604806139904

Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations

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