Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2

COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for investigating antibody responses and assessin...

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Autores principales:	Tove Hoffman, Karolina Nissen, Janina Krambrich, Bengt Rönnberg, Dario Akaberi, Mouna Esmaeilzadeh, Erik Salaneck, Johanna Lindahl, Åke Lundkvist
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	covid-19 sars-cov-2 rapid test igm igg diagnostics Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/c57aa5b203e04993925c9dfddf25b3a0
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spelling	oai:doaj.org-article:c57aa5b203e04993925c9dfddf25b3a02021-11-04T15:00:43ZEvaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-22000-868610.1080/20008686.2020.1754538https://doaj.org/article/c57aa5b203e04993925c9dfddf25b3a02020-01-01T00:00:00Zhttp://dx.doi.org/10.1080/20008686.2020.1754538https://doaj.org/toc/2000-8686COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for investigating antibody responses and assessing individual and potential herd immunity. We evaluated a commercially available test developed for rapid (within 15 minutes) detection of SARS-CoV-2-specific IgM and IgG by 29 PCR-confirmed COVID-19 cases and 124 negative controls. The results revealed a sensitivity of 69% and 93.1% for IgM and IgG, respectively, based solely on PCR-positivity due to the absence of a serological gold standard. The assay specificities were shown to be 100% for IgM and 99.2% for IgG. This indicates that the test is suitable for assessing previous virus exposure, although negative results may be unreliable during the first weeks after infection. More detailed studies on antibody responses during and post infection are urgently needed.Tove HoffmanKarolina NissenJanina KrambrichBengt RönnbergDario AkaberiMouna EsmaeilzadehErik SalaneckJohanna LindahlÅke LundkvistTaylor & Francis Grouparticlecovid-19sars-cov-2rapid testigmiggdiagnosticsInfectious and parasitic diseasesRC109-216ENInfection Ecology & Epidemiology, Vol 10, Iss 1 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 sars-cov-2 rapid test igm igg diagnostics Infectious and parasitic diseases RC109-216
spellingShingle	covid-19 sars-cov-2 rapid test igm igg diagnostics Infectious and parasitic diseases RC109-216 Tove Hoffman Karolina Nissen Janina Krambrich Bengt Rönnberg Dario Akaberi Mouna Esmaeilzadeh Erik Salaneck Johanna Lindahl Åke Lundkvist Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2
description	COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for investigating antibody responses and assessing individual and potential herd immunity. We evaluated a commercially available test developed for rapid (within 15 minutes) detection of SARS-CoV-2-specific IgM and IgG by 29 PCR-confirmed COVID-19 cases and 124 negative controls. The results revealed a sensitivity of 69% and 93.1% for IgM and IgG, respectively, based solely on PCR-positivity due to the absence of a serological gold standard. The assay specificities were shown to be 100% for IgM and 99.2% for IgG. This indicates that the test is suitable for assessing previous virus exposure, although negative results may be unreliable during the first weeks after infection. More detailed studies on antibody responses during and post infection are urgently needed.
format	article
author	Tove Hoffman Karolina Nissen Janina Krambrich Bengt Rönnberg Dario Akaberi Mouna Esmaeilzadeh Erik Salaneck Johanna Lindahl Åke Lundkvist
author_facet	Tove Hoffman Karolina Nissen Janina Krambrich Bengt Rönnberg Dario Akaberi Mouna Esmaeilzadeh Erik Salaneck Johanna Lindahl Åke Lundkvist
author_sort	Tove Hoffman
title	Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2
title_short	Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2
title_full	Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2
title_fullStr	Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2
title_full_unstemmed	Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2
title_sort	evaluation of a covid-19 igm and igg rapid test; an efficient tool for assessment of past exposure to sars-cov-2
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/c57aa5b203e04993925c9dfddf25b3a0
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Evaluation of a COVID-19 IgM and IgG rapid test; an efficient tool for assessment of past exposure to SARS-CoV-2

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